Relationship of TNF-α levels in the Placenta with Blood Pressure, Urinary Albumin, and Fetal Weight Balb/c Strain Mice in Pregnant SLE Models

Abstract

Systematic Lupus Erythematosus (SLE) is one of the autoimmune diseases which, if it occurs at reproductive age, can cause problems during Pregnancy. Tumor Necrosis Factor Alpha (TNF-α) is a proinflammatory cytokine that develops follicles during ovulation, corpus luteum formation, and endometrial function. Therefore, if the Pregnancy increases, it will affect the output results. This study aims to determine the relationship between TNF-α placenta levels with blood pressure, urinary albumin, and fetal body weight in mice of the BALB/c strain of the lupus bunting model. This study was a true experimental (actual experimental) conducted in vivo using balb/c mice experimental animals. The treatment group was given an intraperitoneal injection of 0.5 ml pristane.TNF-α levels were measured using the ELISA method, blood pressure mice with a tail-cuff computerized system tool, and weighing fetal body weight with analytical scales. The result of this study was that there was a significant difference between TNF-α levels between the control and treatment groups. There were significant differences in pregnancy outcomes in the form of blood pressure and urinary albumin in the control and treatment groups. TNF- α levels were associated with increased urine albumin (p=0.01<a). It can be concluded that there is a relationship between the levels of TNF- α in the placenta to the increase in urinary albumin.