Relationship of the tumor necrosis factor-α −308 A/G promoter polymorphism with insulin sensitivity and abdominal fat distribution in Japanese patients with type 2 diabetes mellitus

Fukuda, Masahiko; Yano, Yutaka; Ito, Kuninobu; Gabazza, Esteban C.; Katsuki, Akira; Tanaka, Takashi; Ohtake, Kouhei; Hirata, Naoki; Hori, Yasuko; Araki-Sasaki, Rika; Sumida, Yasuhiro; Adachi, Yukihiko

doi:10.1016/s0168-8227(01)00358-8

Cited by 34 publications

(22 citation statements)

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“…In accordance with previous studies on T2DM [21][22][23][24][25][26][27][28][29][30], we found no association between TNF-α −308G/A polymorphism and T2DM. Although Heijmans et al reported that this polymorphism was associated with T2DM in Dutch people, their patients were aged 85 years and over, which suggests that age contributed to this result, because adverse effects of mild alterations in TNF-α expression become apparent only in old age [31].…”

Section: Discussionsupporting

confidence: 92%

Tumor Necrosis Factor-Alpha Gene Promoter −308G/A and −238G/A Polymorphisms in Mexican Patients with Type 2 Diabetes Mellitus

et al. 2011

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Abstract. The association between some Tumor necrosis factor-alpha (TNF-α) promoter polymorphisms and Type 2 diabetes mellitus (T2DM) remains controversial. Ethnic differences may play a role in these conflicting results. The aim of this study was to investigate the association between −308G/A and −238G/A polymorphisms located in the promoter region of the TNF-α gene and T2DM in Mexican mestizo patients. Nine hundred four individuals (259 patients with T2DM and 645 controls) were genotyped for the −308G/A and −238G/A polymorphisms by PCR-RFLP. We found that the −238A allele increased the risk of developing T2DM in Mexican patients (OR = 1.57, 95% CI: 1.07-2.29; p = 0.018). Moreover, we found that the frequency of the GA haplotype (created by the −308G and −238A alleles) was significantly increased in patients with T2DM when compared with controls (OR = 1.56, 95% CI: 1.05-2.31; p = 0.026). Our results suggest that the −238G/A polymorphism and a specific haplotype (GA) are genetic risk factors for the development of T2DM in Mexican population.

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Section: Discussionsupporting

confidence: 92%

Tumor Necrosis Factor-Alpha Gene Promoter −308G/A and −238G/A Polymorphisms in Mexican Patients with Type 2 Diabetes Mellitus

et al. 2011

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“…The allelic frequencies did not differ among the two groups. No significant effect of this polymorphism was observed on insulin resistance and abdominal fat distribution [18]. In our study though the IAF area was comparable in subjects with and without A allele, the prevalence of high IAF area was more in subjects carrying A allele as compared to those not carrying it (p = 0.06), suggesting some role in the abdominal fat distribution in our population.…”

Section: Discussioncontrasting

confidence: 70%

Associations of −308G/APolymorphism ofTumor Necrosis Factor(TNF)–αGene and Serum TNF-αLevels with Measures of Obesity, Intra-Abdominal and Subcutaneous Abdominal Fat, Subclinical Inflammation and Insulin Resistance in Asian Indians in North India

et al. 2011

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Objectives:Obesity is associated with high levels proinflammatory cytokines like tumour necrosis factor alpha (TNF-α), which may play an important role in the genesis of insulin resistance. We evaluated the relationship of −308G/Apolymorphism ofTNF-αgene with obesity and insulin resistance in Asian Indians in north India.Methods:This cross-sectional study included 151 apparently healthy individuals (79 males, 72 females) 18–50 yrs of age from New Delhi, India. Body composition by dual-energy x-ray absorptiometry (DEXA) and abdominal fat by magnetic resonance imaging (MRI) were measured. Biochemical measurements included OGTT, lipids, fasting insulin, hs-CRP and TNF-αlevels. We analysed −308G/Apolymorphism ofTNF-αgene and studied its association with obesity and biochemical parameters.Results:At comparable BMI, abdominal obesity was more prevalent in females (50%) as compared to males (20%). The wild genotype (GG) was present in 78.8%, GA in 17.9%, andAAin 3.3% subjects. Measures of body composition, abdominal fat distribution, lipids, insulin, hs-CRP and TNF-αlevels were not influenced by the presence of −308G/Apolymorphism. Serum TNF-αlevels correlated significantly with fasting insulin in both genders.Conclusion:TNF-αlevels correlate with fasting insulin but not with indicators of body composition in Asian Indians. The −308G/Apolymorphism ofTNF-αgene is not associated with differences in the serum levels of TNF-αin Asian Indians.

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“…However, the allelic frequency of G-308A was low (1% to 2%) in Japanese subjects a s c o m p a r e d w i t h t h a t ( 1 0 % t o 2 0 % ) i n Caucasians; further, there was no significant association between G-308A and insulin resistance or type 2 diabetes in the Japanese (Ishii et al 2000;Furuta et al 2002).…”

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confidence: 84%

Association of TNF-.ALPHA. Gene Promoter C-857T Polymorphism with Higher Serum LDL Cholesterol Levels and Carotid Plaque Formation in Japanese Patients with Type 2 Diabetes

Yamashina

Kaneko

Maesawa

et al. 2007

Tohoku J. Exp. Med.

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Relationship of the tumor necrosis factor-α −308 A/G promoter polymorphism with insulin sensitivity and abdominal fat distribution in Japanese patients with type 2 diabetes mellitus

Cited by 34 publications

References 19 publications

Tumor Necrosis Factor-Alpha Gene Promoter −308G/A and −238G/A Polymorphisms in Mexican Patients with Type 2 Diabetes Mellitus

Tumor Necrosis Factor-Alpha Gene Promoter −308G/A and −238G/A Polymorphisms in Mexican Patients with Type 2 Diabetes Mellitus

Associations of −308G/APolymorphism ofTumor Necrosis Factor(TNF)–αGene and Serum TNF-αLevels with Measures of Obesity, Intra-Abdominal and Subcutaneous Abdominal Fat, Subclinical Inflammation and Insulin Resistance in Asian Indians in North India

Association of TNF-.ALPHA. Gene Promoter C-857T Polymorphism with Higher Serum LDL Cholesterol Levels and Carotid Plaque Formation in Japanese Patients with Type 2 Diabetes

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