Relationship of the time of storage and transfusion reactions to platelet concentrates from buffy coats

Riccardi, D.; Raspollini, E.; Rebulla, Paolo; Pappalettera, M.; Marangoni, Francesca; Greppi, N.; Sirchia, G.

doi:10.1046/j.1537-2995.1997.37597293886.x

Cited by 30 publications

(15 citation statements)

References 10 publications

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“…These results support the hypothesis that substances accumulated during storage may be a major determinant of adverse effects [115]. Furthermore, this assumption is underlined by results showing storage time-dependent transfusion reactions to buffy coat-derived platelets stored in additive solutions [116]. Cytokine synthesis and subsequent accumulation appears to be reduced or even absent in platelet concentrates prepared from buffy coats and suspended in artificial media without plasma [117,118].…”

Section: Bioactive Substances and Adverse Effectssupporting

confidence: 75%

Clinical Impact of Bioactive Substances in Blood Components: Implications for Leukocyte Filtration

Nielsen¹

1998

Transfus Med Hemother

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Section: Bioactive Substances and Adverse Effectssupporting

confidence: 75%

Clinical Impact of Bioactive Substances in Blood Components: Implications for Leukocyte Filtration

Nielsen¹

1998

Transfus Med Hemother

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“…A number of studies have shown that cytokines such as IL-1β, IL-6, IL-8 and TNF-α are involved in various immune, inflammatory and hemostatic functions [31, 32]and are also associated with both hemolytic and nonhemolytic transfusion reactions [8, 15]. Elevation of these agents has been shown to occur in PCs stored in liquid phase at 22 °C up to 5 days or more [12, 13, 15, 16, 17]as has an increasing incidence of transfusion reactions [33]. This is an important observation because the frequency and severity of FNHTRs have been shown to be correlate directly with the increase in cytokine accumulation which occurs with increasing storage time [12, 13, 14, 15].…”

Section: Discussionmentioning

confidence: 99%

Prevention of Cytokine Accumulation in Platelets Obtained with the COBE Spectra Apheresis System

Palmer

Aye

Dumont³

et al. 1998

Vox Sanguinis

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Background and Objectives: Febrile nonhemolytic transfusion reactions frequently accompany platelet transfusions and may be due to accumulation of cytokines mediating inflammation during storage of platelet concentrates (PCs). We wished to determine whether PCs collected using the COBE® SpectraTM Apheresis System (Version 4) were sufficiently leukocyte reduced (LR) to limit cytokine accumulation during storage. Materials and Methods: Cytokine accumulation – interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α (TNF-α) – and release of platelet α-granule – P-selectin, transforming growth factor-β1 (TGF-β1), platelet-derived growth factor AB (PDGF-AB), von Willebrand factor (vWf) – or dense granule (serotonin) markers were investigated during a 7-day storage period comparing apheresis-collected, LR PCs (LR PCs) and random donor platelets prepared from whole blood (WB). Results: Leukocyte counts were reduced 99.95% comparing LR PCs (5.7 × 10⁵/l) and WB PCs (1.09 × 10⁹/l). Little or no accumulation of leukocyte-derived cytokines was observed in LR PCs during storage in contrast to WB PCs. A reduction in the release of platelet α-granule proteins, such as P-selectin, TGF-β1 and PDGF-AB, was observed on day 0 for LR PCs compared to WB PCs with little or no difference observed from day 3 to 7. Plasma vWf levels were higher in LR PCs compared to WB PCs on days 0–7. Conclusion: Leukocyte levels in PCs collected with the COBE Spectra Apheresis System are sufficiently low to limit cytokine production during 7 days of storage.

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“…In each case of suspected transfusion reaction, the clinician completed a ‘Report of Suspected Transfusion Reaction’ form that included patient information, the type and unique identifier of the blood product, times of transfusion and reaction, vital signs, symptoms of the suspected reaction, any intervention required, and outcome. These forms were submitted to the blood bank, whose medical director reviewed the form, the results of laboratory studies, and, if necessary, other information from the medical record to arrive at an interpretation of the event based on terminology in the American Association of Blood Banks (AABB) Technical Manual (Brecher, 2002) and other published studies of acute transfusion reactions (Buck et al , 1987; Heddle et al , 1993; Riccardi et al , 1997; Heddle, 1999; Perrotta & Snyder, 2001; Wang et al , 2002; Domen & Hoeltge, 2003). Specifically, febrile reactions were defined as a new temperature ≥38°C or an increase in temperature of ≥1°C above baseline that developed during or within 3 hours of completion of a transfusion in which another cause of fever, such as sepsis or haemolysis, was excluded.…”

Section: Methodsmentioning

confidence: 99%

Premedication with acetaminophen or diphenhydramine for transfusion with leucoreduced blood products in children

et al. 2005

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Summary Febrile non‐haemolytic or allergic reactions occur in 0·1–30% of transfusions; physicians often premedicate patients with acetaminophen or diphenhydramine to prevent these reactions. The effectiveness of this practice has not been demonstrated. In this retrospective review of all transfusions at our institution during 2002, 385 patients received 7900 evaluable leucoreduced, irradiated blood products (4280 single‐donor apheresis platelets and 3620 packed red blood cells). Febrile reactions occurred in 0·95% of 4108 transfusions with, and 0·53% of 3792 transfusions without, acetaminophen premedication. Allergic reactions occurred in 0·90% of 4315 transfusions with, and 0·56% of 3585 transfusions without, diphenhydramine premedication. In a multivariate analysis that adjusted for age, patient category, transfusion location, product, transfusion history, and reaction history, premedication with acetaminophen was associated with a statistically non‐significant increase in the odds of a febrile reaction (odds ratio 1·74; 95% confidence interval 0·71–4·23; P = 0·22), and diphenhydramine with a non‐significant increase in allergic reactions (odds ratio 1·74; 95% confidence interval 0·99–3·06; P = 0·054). Reactions occurred in only 1·3% of the 518 transfusions to patients with a history of two or more prior reactions. Febrile and allergic transfusion reactions were rare in paediatric patients transfused with leucoreduced, irradiated blood products, whether premedication was used or not.

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Relationship of the time of storage and transfusion reactions to platelet concentrates from buffy coats

Abstract: Time of storage seems to be an important variable associated with BC-PC transfusion reaction.

Cited by 30 publications

References 10 publications

Clinical Impact of Bioactive Substances in Blood Components: Implications for Leukocyte Filtration

Clinical Impact of Bioactive Substances in Blood Components: Implications for Leukocyte Filtration

Prevention of Cytokine Accumulation in Platelets Obtained with the COBE Spectra Apheresis System

Premedication with acetaminophen or diphenhydramine for transfusion with leucoreduced blood products in children

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