Relationship of systemic IL-10 levels with proinflammatory cytokine responsiveness and lung function in agriculture workers

LeVan, Tricia D.; Romberger, Debra J.; Siahpush, Mohammad; Grimm, Brandon; Ramos, Athena K.; Johansson, Patrik; Michaud, Tzeyu L.; Heires, Art J.; Wyatt, Todd A.; Poole, Jill

doi:10.1186/s12931-018-0875-z

Cited by 17 publications

(16 citation statements)

References 42 publications

(42 reference statements)

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“…In the present study, it was found similar response, since policemen working in a shiftwork scale presented reduced levels of IL‐10 and reduced FEV1. These findings reinforce the findings of previous studies performed in asthmatics, 25 demonstrating a possible association between lower levels of IL‐10 with airway inflammation and airway obstruction. In fact, this concept that low levels of IL‐10 can be associated with airway obstruction is strengthened by the present study, since that such phenomena were also found in non‐asthmatic patients.…”

Section: Discussionsupporting

confidence: 91%

“…On the other side, increased levels of blood IL‐10, an immunomodulatory and anti‐inflammatory cytokine has been associated increased and better FEV1/FVC values, which is also an important marker of airway obstruction 25 . In the present study, it was found similar response, since policemen working in a shiftwork scale presented reduced levels of IL‐10 and reduced FEV1.…”

Section: Discussionsupporting

confidence: 72%

See 1 more Smart Citation

Chronic alteration of circadian rhythm is related to impaired lung function and immune response

Aquino-Santos

Tavares-Vasconcelos²,

Brandão-Rangel

et al. 2020

Int. J. Clin. Pract.

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Background Alterations of the circadian rhythm negatively impact several aspects of the health, including the lung function. Chronic shiftwork scale classically induces alterations in the circadian rhythm. However, its effects on pulmonary immune response are unknown. Aims To evaluate the impact of chronic alteration of circadian rhythm on pulmonary function and immune response. Methods In this context, a 12 × 24 hours and 12 × 48 hours work scale in shiftwork scale policemen (n = 25; 38.73 ± 6.92 years old) were compared with fixed work scale (8 h/d) civil men (n = 25; 34.00 ± 9.60 years old) who were evaluated for perceived stress, sleepiness, physical activity levels, anthropometric characteristics, lung function, pulmonary and systemic cellular and humoral immune response. Results Policemen presented increased levels of perceived stress (P < .0008), impaired sleepiness (P < .04) and lung function as demonstrated by reduced forced vital capacity (FVC) (P < .053) and FEV1 (P < .043) when compared with civil men. In addition, increased levels of exhaled nitric oxide (P < .037) and of IL‐2 (P < .0046) in the breath condensate revealed that policemen presented chronic lung inflammation compared with civil men. Although the whole blood analysis did not showed any differences between the two groups concerning the number of leucocytes, the humoral response revealed that policemen presented increased levels of IL‐2 (P < .002) and lower levels of IL‐10 (P < .001), clearly displaying a clinical status of low‐grade inflammation. Conclusions Chronic alteration of circadian rhythm in shiftwork scale policemen results in impaired lung function, beyond to impair pulmonary and systemic immune function.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 72%

Chronic alteration of circadian rhythm is related to impaired lung function and immune response

Aquino-Santos

Tavares-Vasconcelos²,

Brandão-Rangel

et al. 2020

Int. J. Clin. Pract.

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“…In relation to marathons, our group previously demonstrated that marathon runners who had increased IL-10 levels in the circulation immediately after the marathon and also in the nasal mucosa 72 hours after the marathon did not present upper respiratory symptoms [12,33]. In addition, it has been also reported that systemic IL-10 can modulate the pulmonary function by modulating the inflammatory response of the airways [29,45], including that associated with physical exercise [50,51]. However, studies that aimed to evaluate the effect of IL-10 in the context of EIB are scarce [52,53].…”

Section: Discussionmentioning

confidence: 95%

“…Another factor that may influence the similar performance observed between the two groups is the higher circulant IL-10 levels found immediately after the marathon. It is well-known that IL-10 has a potent anti-inflammatory and proresolving properties [45] and, in the airways, can act as a protective factor against mucosal inflammation [46].…”

Section: Discussionmentioning

confidence: 99%

The Relationship of IL-8 and IL-10 Myokines and Performance in Male Marathon Runners Presenting Exercise-Induced Bronchoconstriction

Santos

Bachi

Luna

et al. 2020

IJERPH

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At present, it is unclear which exercise-induced factors, such as myokines, could diminish the negative impact of the reduction in pulmonary function imposed by the exercise in question. In this study, we aim to evaluate the prevalence of exercise-induced bronchoconstriction (EIB) and also to investigate the effect of myokines in the performance of marathon runners presenting EIB or not. Thirty-eight male recreational marathon runners (age 38.8 [33–44], height 175.7 [172.0–180.3]; weight 74.7 [69.3–81.6]) participated in this study, and through spirometry tests, a prevalence of 23.6% of EIB was found, which is in agreement with the literature. The volunteers who tested positive to EIB (EIB+) presented lower maximum aerobic capacity compared to those who tested negative (EIB−) (EIB+ 44.02 [39.56–47.02] and EIB− 47.62 [44.11–51.18] p = 0.03). The comparison of plasma levels of IL-1β (EIB+ p = 0.296, EIB− p = 0.176, EIB+ vs. EIB− baseline p = 0.190 immediately after p = 0.106), IL-4 (undetectable), IL-6 (EIB+ p = 0.003, EIB− p ≤ 0.001, EIB+ vs. EIB− baseline p = 0.301 immediately after p = 0.614), IL-8 (EIB+ p = 0.003, EIB− p ≤ 0.001, EIB+ vs. EIB− baseline p = 0.110 immediately after p = 0.453), IL-10 (EIB+ p = 0.003, EIB− p ≤ 0.001, EIB+ vs. EIB− baseline p = 0.424 immediately after p = 0.876) and TNF-α (EIB+ p = 0.003, EIB− p ≤ 0.001, EIB+ vs. EIB− baseline p = 0.141 immediately after p = 0.898) were similar in both groups 24 h before and immediately after the marathon. However, negative correlations were found between the marathon finishing time and the levels of IL-8 (r = −0.81, p = 0.022), and IL-10 (r = −0.97, p ≤ 0.001) immediately after completing the marathon. In conclusion, for the first time, it is shown that the myokines IL-8 and IL-10 are related to improvement of the performance of marathon runners presenting EIB.

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“…Apart from the regulatory role and direct action of IL-4 on effector cells in allergic inflammation, this cytokine also appears to have actions relevant to smoking-related diseases. IL-10 is an anti-inflammatory and pro-resolving factor that can work to inhibit pro-inflammatory cytokines [22] . Increased IL-4 is associated with allergic airway response; [23] and both IL-4 and IL-10 alter macrophage lipid metabolism [24] .…”

Section: Discussionmentioning

confidence: 99%

Lipid laden macrophages and electronic cigarettes in healthy adults

et al. 2020

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Background An outbreak of E-cigarette or Vaping Product Use-Associated Lung Injury (EVALI) with significant morbidity and mortality was reported in 2019. While most patients with EVALI report vaping tetrahydrocannabinol (THC) oils contaminated with vitamin E acetate, a subset report only vaping with nicotine-containing electronic cigarettes (e-cigs). Whether or not e-cigs cause EVALI, the outbreak highlights the need for identifying long term health effects of e-cigs. EVALI pathology includes alveolar damage, pneumonitis and/or organizing pneumonia, often with lipid-laden macrophages (LLM). We assessed LLM in the lungs of healthy smokers, e-cig users, and never-smokers as a potential marker of e-cig toxicity and EVALI. Methods A cross-sectional study using bronchoscopy was conducted in healthy smokers, e-cig users, and never-smokers ( n = 64). LLM, inflammatory cell counts, and cytokines were determined in bronchial alveolar fluids (BAL). E-cig users included both never-smokers and former light smokers. Findings High LLM was found in the lungs of almost all smokers and half of the e-cig users, but not those of never-smokers. LLM were not related to THC exposure or smoking history. LLM were significantly associated with inflammatory cytokines IL-4 and IL-10 in e-cig users, but not smoking-related cytokines. Interpretation This is the first report of lung LLM comparing apparently healthy smokers, e-cig users, and never-smokers. LLM are not a specific marker for EVALI given the frequent positivity in smokers; whether LLMs are a marker of lung inflammation in some e-cig users requires further study. Funding The National Cancer Institute, the National Heart, Lung, and Blood Institute, the Food and Drug Administration Center for Tobacco Products, the National Center For Advancing Translational Sciences, and Pelotonia Intramural Research Funds

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Relationship of systemic IL-10 levels with proinflammatory cytokine responsiveness and lung function in agriculture workers

Cited by 17 publications

References 42 publications

Chronic alteration of circadian rhythm is related to impaired lung function and immune response

Chronic alteration of circadian rhythm is related to impaired lung function and immune response

The Relationship of IL-8 and IL-10 Myokines and Performance in Male Marathon Runners Presenting Exercise-Induced Bronchoconstriction

Lipid laden macrophages and electronic cigarettes in healthy adults

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