Relationship of Structural Characteristics to Biomechanical Profile in Normal, Keratoconic, and Crosslinked Eyes

Vaidehi, V.; Kumar, Naresh; Males, John; Graham, Stuart L.

doi:10.1097/ico.0000000000000434

Cited by 27 publications

(24 citation statements)

References 31 publications

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“…Wong and Lam reported positive correlation both with CH and CRF [9]. In a recent study both CH and CRF were found to be correlated positively with CC and CV for the normal, keratoconic, and crosslinked eyes [22]. In this study, there are also positive correlations noted between CH, CRF, and CV.…”

Section: Discussionsupporting

confidence: 69%

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Relationship among Corneal Biomechanics, Anterior Segment Parameters, and Geometric Corneal Parameters

Çevik

Kıvanç

Budak

et al. 2016

Journal of Ophthalmology

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Purpose. To investigate the relationship between corneal biomechanical parameters, anterior segment parameters, and geometric corneal parameters in a healthy Caucasian group. Methods. This retrospective study included the healthy eyes with best corrected visual acuity of at least 20/40 of 122 Caucasian subjects. The anterior segment parameters and geometric corneal parameters such as corneal volume, central corneal thickness, horizontal and vertical corneal radii, anterior and posterior steep, and flat keratometric values were measured with a Scheimpflug camera. The biomechanical properties were measured with Ocular Response Analyzer. Results. One hundred and twenty-two healthy Caucasian subjects (67 males, 55 females) with a mean age of 45.32 ± 20.23 were enrolled. Both corneal hysteresis and corneal resistance factor were positively correlated with CCT (r = 0.529, p < 0.001; r = 0.638, p < 0.001) and CV (r = 0.635, p < 0.001; r = 0.579, p < 0.001) and negatively correlated with age (r = −0.373, p < 0.001; r = −0.249, p < 0.001). Both in age-gender and multivariate models, CH and CRF had statistically significant negative association with the posterior steep K value. Conclusions. CH and CRF are negatively correlated with posterior steep and average posterior K values.

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Section: Discussionsupporting

confidence: 69%

“…This finding may suggest that posterior surface of the cornea may affect corneal biomechanical properties more compared to anterior surface in normal eyes. In a recent study, it has been shown that CH and CRF were negatively associated with K max value in keratoconic eyes, but this correlation did not exist for normal eyes [22]. …”

Section: Discussionmentioning

confidence: 99%

Relationship among Corneal Biomechanics, Anterior Segment Parameters, and Geometric Corneal Parameters

Çevik

Kıvanç

Budak

et al. 2016

Journal of Ophthalmology

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“…In that aspect, in all patients, preoperative CCT, CTP and CV should be evaluated carefully. Unlike with our results, Viswanathan et al (31) determined a positive correlation of both CH and CRF with CCT in the normal, keratoconic and crosslinked eyes.…”

Section: Discussioncontrasting

confidence: 99%

Alterations in corneal biomechanical and topographic features after accelerated crosslinking: 1 year results

Kirgiz¹

2019

Beyoglu Eye J

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To determine the biomechanical and topographic alterations within the first year after accelerated crosslinking (CXL) treatment in patients with keratoconus. Methods: In this prospective study, 52 eyes of 52 patients with progressive keratoconus underwent accelerated CXL were included. All patients had a detailed preoperative ophthalmologic examination, including slit-lamp evaluation, Goldmann tonometry, fundoscopy, topography by Scheimpflug imaging (Sirius), and corneal biomechanical evaluation with a biomechanical waveform analysis device (ORA). Alterations in visual acuity and topographic findings were evaluated before the treatment and at 12 months follow-up. Corneal biomechanical features were obtained before the treatment, and at 1 st , 3 rd , 6 th and 12 th months. Results: Uncorrected-visual acuity and best-corrected visual acuity both statistically significantly improved at 12 th month (p=0.001). There were no statistically significant differences in keratometry values, whereas maximum K (AKfront) and symmetry index front (SIfront) decreased significantly (p=0.015 and p=0.009, respectively). Corneal thinnest point and volume also decreased significantly at 12 th month (p=0.001 for both). Goldmann-correlated intraocular pressure (IOPg) and corneal compensated IOP (IOPcc) values transiently increased in the first three months, while corneal hysteresis (CH) and the corneal resistance factor (CRF) transiently decreased, with the difference not statistically significant (p>0.05). However, central corneal thickness significantly decreased at the end of the 12 th month (p=0.001). Conclusion: Accelerated CXL seems to be effective in stopping the progression of keratoconus. Our findings showed transient alterations in biomechanical features, which will end with the preoperative values at the end of the 12 th month. Further studies are needed to demonstrate the changes in corneal biomechanics in vivo.

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“…The cornea is a soft tissue located in the outer layer of the eyeball. The transparent cornea provides 70% ocular refractive power [ 1 , 2 ]. Cornea can not only guarantee the external light to project to the retina directly, but also play an important role in maintaining the normal shape of the eyeball [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…The transparent cornea provides 70% ocular refractive power [ 1 , 2 ]. Cornea can not only guarantee the external light to project to the retina directly, but also play an important role in maintaining the normal shape of the eyeball [ 2 ]. The maintenance of normal corneal morphology has great significance in the prevention of myopia and keratoconus, and the changes of corneal morphology under different IOPs are closely related to corneal biomechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Age-Related Variations of Rabbit Corneal Geometrical and Clinical Biomechanical Parameters

Zhang

Xiao

Cao

et al. 2017

BioMed Research International

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Purpose To study the variations in corneal clinical biomechanical parameters (CCBP) and corneal geometrical parameters of rabbit in relation to age. Methods Rabbits aged 3, 7, 12, 18, and 24 months were enrolled. Each eye of the rabbits was tested with Ocular Response Analyzer (ORA), Optical Coherence Tomography (OCT), and Pachymeter to obtain the intraocular pressure (IOP): Goldmann-correlated IOP (IOPg) and Corneal Compensated Intraocular Pressure (IOPcc); CCBP: Corneal Hysteresis (CH) and Corneal Resistance Factor (CRF); corneal geometric parameters: corneal curvature radius (CCR) and central corneal thickness (CCT). Results The IOP of the rabbits changes slightly from 3 to 7 months of age, while it significantly decreases from 7 to 18 months of age and increases from 18 to 24 months of age; CH and CRF decrease with the increase of age; CCT increases from 7 to 18 months and decreases from 3 to 7 months of age and from 18 to 24 months of age; CCR presents an upward trend from 3 to 18 months and a significant decrease between 18 and 24 months of age. Conclusion CH and CRF are negatively correlated with age. CCT and CCR are positively correlated with age.

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Relationship of Structural Characteristics to Biomechanical Profile in Normal, Keratoconic, and Crosslinked Eyes

Cited by 27 publications

References 31 publications

Relationship among Corneal Biomechanics, Anterior Segment Parameters, and Geometric Corneal Parameters

Relationship among Corneal Biomechanics, Anterior Segment Parameters, and Geometric Corneal Parameters

Alterations in corneal biomechanical and topographic features after accelerated crosslinking: 1 year results

Age-Related Variations of Rabbit Corneal Geometrical and Clinical Biomechanical Parameters

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