Relationship of serum levels of interleukin 6, interleukin 8, and C-reactive protein with forced expiratory volume in first second in patients with mustard lung and chronic obstructive pulmonary diseases: systematic review and meta-analysis

Shahriary, Alireza; Panahi, Yunes; Shirali, Saeed; Rahmani, Hossein A.

doi:10.5114/ada.2017.67841

Cited by 22 publications

(20 citation statements)

References 32 publications

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“…However, the level of lutein correlated both ways to inflammatory markers, negatively to IL-6, and positively to hs-CRP. In COPD subjects, the level of hs-CRP may reflect disease severity better than the level of IL-6, as was suggested by a recent meta-analysis study [39]. In that study, serum levels of CRP correlated negatively and significantly to FEV 1 in COPD subjects ( r = −0.13, p = 0.012), while serum levels of IL-6 did not [39].…”

Section: Discussionmentioning

confidence: 85%

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT

Kentson

Leanderson

Jacobson

et al. 2018

European Clinical Respiratory Journal

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Background: The pathogenesis of chronic obstructive pulmonary disease (COPD) is associated with oxidative stress. Both iron (Fe) and oxygen are involved in the chemical reactions that lead to increased formation of reactive oxygen species. Oxidative reactions are prevented by antioxidants such as carotenoids. Objective: To study the differences in Fe status, carotenoid levels, healthy eating habits, and markers of inflammation and oxidative damage on proteins in subjects with severe COPD ± long-term oxygen therapy (LTOT) and lung-healthy control subjects. Methods: Sixty-six Caucasians with advanced COPD (28 with LTOT) and 47 control subjects were included. Questionnaires about general health, lifestyle, and dietary habits were answered. Lung function tests and blood sampling were performed. Results: COPD subjects (±LTOT) did not demonstrate increased oxidative damage, assessed by protein carbonylation (PC), while levels of soluble transferrin receptors (sTfRs) were slightly elevated. Soluble TfRs, which is inversely related to Fe status, was negatively associated with PC. Levels of carotenoids, total and β-cryptoxanthin, α- and β-carotenes, were significantly lower in COPD subjects, and their diet contained significantly less fruits and vegetables. Lutein correlated inversely with IL-6, lycopene correlated inversely with SAT, while β-carotene was positively associated with a Mediterranean-like diet. Conclusions: Fe could favor oxidative stress in COPD patients, suggesting a cautious use of Fe prescription to these patients. COPD subjects ate a less healthy diet than control subjects did and would, therefore, benefit by dietary counseling. COPD patients with hypoxemia are probably in particular need of a lycopene-enriched diet.

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Section: Discussionmentioning

confidence: 85%

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT

Kentson

Leanderson

Jacobson

et al. 2018

European Clinical Respiratory Journal

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“…Additionally, TNF‐α and CRP may exacerbate the integrity destruction of pulmonary alveoli and small airway smooth muscle cells, and promote the remodeling of bronchial tissue, finally affecting the stability of airway flow . In a meta‐analysis of Shahriary et al, the serum levels of CRP and TNF significantly increased in COPD patients, and there was a significant reverse relationship between CRP and FEV 1 . Moreover, PCT is a highly stable procalcitonin precursor molecule secreted by thyroid C cells .…”

Section: Discussionmentioning

confidence: 99%

Correlations between serum amyloid A, C‐reactive protein and clinical indices of patients with acutely exacerbated chronic obstructive pulmonary disease

Lin

Chen

Ding

et al. 2019

Clinical Laboratory Analysis

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BackgroundTo explore the correlations between SAA, CRP, and clinical indices of patients with acutely exacerbated chronic obstructive pulmonary disease (AECOPD).MethodsA total of 120 patients with AECOPD and another 120 with remitted COPD were enrolled in an AECOPD group and a COPD remission group, respectively. Meanwhile, 120 healthy subjects were included as a control group. SAA, CRP, PCT, Fbg, IL‐8, IL‐6, TNF‐α, and IP‐10 levels were detected. FEV1 and FEV1/FVC were measured.ResultsCompared with control group, the serum levels of SAA, CRP, PCT, Fbg, IL‐8, IL‐6, TNF‐α, and IP‐10 significantly increased in COPD remission group (P < 0.05). The levels of AECOPD group significantly exceeded those of COPD remission group (P < 0.05). The levels of AECOPD patients with different GOLD grades were significantly different (P < 0.05). AECOPD group had significantly lower FEV1 and FEV1/FVC than those of COPD remission group (P < 0.05). The CAT score of AECOPD patients was (18.41 ± 2.55) points. The levels of SAA, CRP, PCT, Fbg, IL‐8, IL‐6, TNF‐α, and IP‐10 were negatively correlated with FEV1 and FEV1/FVC, and positively correlated with CAT score. The area under receiver operating characteristic curve of SAA was largest (0.931). The cutoff values for SAA, CRP, PCT and Fbg were 18.68 mg/L, 14.70 mg/L, 0.39 μg/L, 3.91 g/L, 0.46 μg/L, 24.17 μg/L, 7.18 mg/L, and 83.19 ng/L, respectively.ConclusionsSerum levels of SAA, CRP, PCT, Fbg, IL‐8, IL‐6, TNF‐α, and IP‐10 in AECOPD patients were elevated, which may undermine pulmonary functions. SAA can be used as an effective index for AECOPD diagnosis and treatment.

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“…Application of albumin/globulin ratio in elderly patients with acute exacerbation of chronic obstructive pulmonary disease and prealbumin (PA) play an important role in immunity and inflammation throughout the body (3). The albumin/ globulin ratio (AGR) can be calculated by measuring the total serum protein and albumin concentrations.…”

Section: Original Articlementioning

confidence: 99%

“…The AGR can be used for prognostic evaluation of tumors (4,5). Although serum albumin and globulin were thought to correlate with AECOPD progression, few reports have described the application of the AGR to AECOPD (3,6). This study was performed to assess the relationship between the AGR and AECOPD in elderly patients and explore the application value of the AGR in AECOPD assessment, progression, and prognosis in the elderly population.…”

Section: Original Articlementioning

confidence: 99%

Application of albumin/globulin ratio in elderly patients with acute exacerbation of chronic obstructive pulmonary disease

Qin¹,

Qin²,

Wu³

et al. 2018

J. Thorac. Dis.

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Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has become an important disease of hospitalized elderly patients, which lack simple and inexpensive indicators for evaluating the condition and prognosis. This study was performed to investigate the clinical significance of the serum albumin/globulin ratio (AGR) in elderly patients with AECOPD.Methods: The data of 252 hospitalized elderly patients with AECOPD, 89 stable COPD patients and 115 elderly healthy individuals were analyzed and compared. The differences in the AGR, logarithm of the serum C-reactive protein (LogCRP) level, prealbumin (PA) level, and immunoglobulin G (IgG) level were compared. AECOPD patients were grouped using the optimal cutoff values of each index to compare the difference in the combined infection rate. The correlation between hospital stays and AGR was analyzed. Results: The AGR, LogCRP, PA level, and IgG level were different among the AECOPD group, stable COPD group and healthy control groups (P<0.05). The AGR, LogCRP, and PA level were different (P<0.05) among the Global Initiative for Chronic Obstructive Lung Disease (GOLD) I, II, II, and IV groups. Age, AGR, LogCRP, and PA level were different (P<0.05) between the infection and non-infection groups. After grouping according to the optimal cutoff values, the combined infection rate was different (P<0.05). The AGR was negatively correlated with the hospital stay (r=−0.583, P<0.001). The hospital stay was longer in patients with an AGR of <1.37 than ≥1.37 (P<0.001). Conclusions: The AGR can be regarded as a reference index for evaluating the condition of elderly patients with AECOPD, determining the presence of combined infection, and predicting the prognosis. Keywords: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD); combined infection; albumin/globulin ratio (AGR); C-reactive protein (CRP); prealbumin (PA) Qin et al. The role of serum AGR in AECOPD J Thorac Dis 2018;10(8):4923-4930 jtd.amegroups.com Qin et al. The role of serum AGR in AECOPD Comparison of each index between AECOPD patients with and without infection

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Relationship of serum levels of interleukin 6, interleukin 8, and C-reactive protein with forced expiratory volume in first second in patients with mustard lung and chronic obstructive pulmonary diseases: systematic review and meta-analysis

Cited by 22 publications

References 32 publications

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT

Correlations between serum amyloid A, C‐reactive protein and clinical indices of patients with acutely exacerbated chronic obstructive pulmonary disease

Application of albumin/globulin ratio in elderly patients with acute exacerbation of chronic obstructive pulmonary disease

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