Application of albumin/globulin ratio in elderly patients with acute exacerbation of chronic obstructive pulmonary disease

Abstract

Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has become an important disease of hospitalized elderly patients, which lack simple and inexpensive indicators for evaluating the condition and prognosis. This study was performed to investigate the clinical significance of the serum albumin/globulin ratio (AGR) in elderly patients with AECOPD.Methods: The data of 252 hospitalized elderly patients with AECOPD, 89 stable COPD patients and 115 elderly healthy individuals were analyzed and compared. The differences in the AGR, logarithm of the serum C-reactive protein (LogCRP) level, prealbumin (PA) level, and immunoglobulin G (IgG) level were compared. AECOPD patients were grouped using the optimal cutoff values of each index to compare the difference in the combined infection rate. The correlation between hospital stays and AGR was analyzed. Results: The AGR, LogCRP, PA level, and IgG level were different among the AECOPD group, stable COPD group and healthy control groups (P<0.05). The AGR, LogCRP, and PA level were different (P<0.05) among the Global Initiative for Chronic Obstructive Lung Disease (GOLD) I, II, II, and IV groups. Age, AGR, LogCRP, and PA level were different (P<0.05) between the infection and non-infection groups. After grouping according to the optimal cutoff values, the combined infection rate was different (P<0.05). The AGR was negatively correlated with the hospital stay (r=−0.583, P<0.001). The hospital stay was longer in patients with an AGR of <1.37 than ≥1.37 (P<0.001). Conclusions: The AGR can be regarded as a reference index for evaluating the condition of elderly patients with AECOPD, determining the presence of combined infection, and predicting the prognosis. Keywords: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD); combined infection; albumin/globulin ratio (AGR); C-reactive protein (CRP); prealbumin (PA) Qin et al. The role of serum AGR in AECOPD J Thorac Dis 2018;10(8):4923-4930 jtd.amegroups.com Qin et al. The role of serum AGR in AECOPD Comparison of each index between AECOPD patients with and without infection

<p>The Role of Albumin/Globulin Ratio in Discharged COVID-19 Patients with Re-Positive Nucleic Acid Detection</p>

“…5 It can be regarded as an index for predicting the prognosis of AECOPD and other inflammatory diseases. 6 Recent studies indicated that a low AGR may respect a susceptible state to infection. 5,6 We suggested that "re-positive" patients may not sufficiently apparent the virus.…”

“… 6 Recent studies indicated that a low AGR may respect a susceptible state to infection. 5 , 6 We suggested that “re-positive” patients may not sufficiently apparent the virus. Our results indicated that AGR may potentially have a predictive effect in “re-positive” discharged COVID-19 patients.…”

Predictive Values of Biochemical Markers As Early Indicators for Severe COVID-19 Cases in Admission

“…Changes in serum globulins are thought to be indicative of inflammation and/or host immune response [ 76 ]. A study in the literature found that both CVD-related and independent mortality was high in chronic kidney disease patients with low AGR [ 26 ]. It has been stated in different studies that AGR can be used in the prognostic evaluation of tumors such as HCC, ureteral carcinoma, ovarian and gastric cancer [ 77 , 78 ].…”

“…Some studies have found that the albumin/globulin ratio (AGR) is associated with mortality in chronic obstructive pulmonary disease and chronic renal failure [ 26 , 27 ].…”

Analysis of the influencing factors and nursing strategy for acute atelectasis after traumatic brain injury surgery

“…Also, especially after Enterobacteriaceae infection, the expression of ALB mRNA in patients is inhibited, and hypoproteinemia is prone to occur. Hypoproteinemia will weaken respiratory defenses and immune function, making patients with TBI more vulnerable to pathogenic microorganisms, viruses, and various inflammatory cells (19). The invasion of a large number of bacteria can aggravate lung infections, promote alveolar exudation, increase secretions, block alveoli, and induce atelectasis.…”