Relationship of serum interleukin‐7 concentration and the coagulation state in children with nephrotic syndrome

Wasilewska, Anna; Zoch-Zwierz, W; Tomaszewska, Barbara; Żelazowska, Beata

doi:10.1111/j.1442-200x.2005.02078.x

Cited by 13 publications

(13 citation statements)

References 22 publications

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“…As mentioned earlier, the platelets are also known to release several growth factors, which probably explain the decreased levels of both VEGF and PDGF in the event of thrombocytopenia. Elevated levels of IL-7, conversely, have been previously shown to be involved in thrombocytosis [58]. During defervescence, the low levels of IL-5 probably deregulated functional PAF on eosinophils [59].…”

Section: Discussionmentioning

confidence: 99%

Cytokine Expression Profile of Dengue Patients at Different Phases of Illness

et al. 2012

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BackgroundDengue is an important medical problem, with symptoms ranging from mild dengue fever to severe forms of the disease, where vascular leakage leads to hypovolemic shock. Cytokines have been implicated to play a role in the progression of severe dengue disease; however, their profile in dengue patients and the synergy that leads to continued plasma leakage is not clearly understood. Herein, we investigated the cytokine kinetics and profiles of dengue patients at different phases of illness to further understand the role of cytokines in dengue disease.Methods and FindingsCirculating levels of 29 different types of cytokines were assessed by bead-based ELISA method in dengue patients at the 3 different phases of illness. The association between significant changes in the levels of cytokines and clinical parameters were analyzed. At the febrile phase, IP-10 was significant in dengue patients with and without warning signs. However, MIP-1β was found to be significant in only patients with warning signs at this phase. IP-10 was also significant in both with and without warning signs patients during defervescence. At this phase, MIP-1β and G-CSF were significant in patients without warning signs, whereas MCP-1 was noted to be elevated significantly in patients with warning signs. Significant correlations between the levels of VEGF, RANTES, IL-7, IL-12, PDGF and IL-5 with platelets; VEGF with lymphocytes and neutrophils; G-CSF and IP-10 with atypical lymphocytes and various other cytokines with the liver enzymes were observed in this study.ConclusionsThe cytokine profile patterns discovered between the different phases of illness indicate an essential role in dengue pathogenesis and with further studies may serve as predictive markers for progression to dengue with warning signs.

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Section: Discussionmentioning

confidence: 99%

Cytokine Expression Profile of Dengue Patients at Different Phases of Illness

et al. 2012

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“…IL-7 is known to be a powerful inducer of T and B lymphopoiesis, moreover many studies link IL-7 to inflammatory diseases [21], [24], [25] and bone loss in estrogen deficiency conditions [22], [26]. Our study focused on IL-7 involvement in the spontaneous osteoclastogenesis occurring in cancer patients with osteolytic metastasis.…”

Section: Discussionmentioning

confidence: 99%

IL-7 Up-Regulates TNF-α-Dependent Osteoclastogenesis in Patients Affected by Solid Tumor

et al. 2006

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BackgroundInterleukin-7 (IL-7) is a potent regulator of lymphocyte development, which has also significant effects on bone; in fact it is a potent osteoclastogenic factor. Some human solid tumors produce high IL-7 levels, suggesting a potential IL-7 role on tumor development and progression.MethodologyWe studied 50 male patients affected by solid tumors, and their blood samples were collected at tumor diagnosis. PBMCs were isolated and cultured with/without IL-7 to study its influence on osteoclastogenesis. Serum and cell culture supernatant IL-7 levels were measured by ELISA. The quantitative analysis of IL-7 expression on T and B cells was performed by Real-Time PCR.Principal FindingsSerum IL-7 levels were highest in osteolytic cancer patients, followed by cancer patients without bone lesions, and then healthy controls. We showed the IL-7 production in PBMC cultures and particularly in monocyte and B cell co-cultures. A quantitative analysis of IL-7 expression in T and B cells confirmed that B cells had a high IL-7 expression. In all cell culture conditions, IL-7 significantly increased osteoclastogenesis and an anti-IL-7 antibody inhibited it. We demonstrated that IL-7 supports OC formation by inducing the TNF-α production and low RANKL levels, which synergize in promoting osteoclastogenesis.ConclusionsWe demonstrated the presence of high serum IL-7 levels in patients with bone metastasis, suggesting the use of serum IL-7 level as a clinical marker of disease progression and of bone involvement. Moreover, we showed the capability of IL-7 to stimulate spontaneous osteoclastogenesis of bone metastatic patients and to induce osteoclastogenesis in cancer patients without bone involvement. These findings add further details to the disclosure of the mechanisms controlling bone metastasis in solid tumors.

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“…β-thromboglobulin, a platelet-specific protein, was repeatedly found to be elevated in adults during NS [23,25,37,42,43]. Platelet-derived growth factor (PDGF) [30] and interleukin-7 (IL-7) [44] were increased in pediatric patients during NS, while plasma levels of platelet factor 4, another α-granule component, were normal [23,25]. Plasma levels of the soluble form of P-selectin were elevated in both adults and children during idiopathic NS [37,45].…”

Section: Increased Release Of Active Substancesmentioning

confidence: 99%

Platelet abnormalities in nephrotic syndrome

et al. 2015

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Nephrotic syndrome (NS) is a common kidney disease associated with a significantly increased risk of thrombotic events. Alterations in plasma levels of pro- and anti-coagulant factors are involved in the pathophysiology of venous thrombosis in NS. However, the fact that the risk of both venous and arterial thrombosis is elevated in NS points to an additional role for blood platelets. Increased platelet counts and platelet hyperactivity have been observed in nephrotic children. Platelet hyperaggregability, increased release of active substances, and elevated surface expression of activation-dependent platelet markers have been documented. The mechanisms underlying those platelet alterations are multifactorial and are probably due to changes in plasma levels of platelet-interfering proteins and lipid changes, as a consequence of nephrosis. The causal relationship between platelet alterations seen in NS and the occurrence of thromboembolic phenomena remains unclear. Moreover, the efficiency of prophylactic treatment using antiplatelet agents for the prevention of thrombotic complications in nephrotic patients is also unknown. Thus, antiplatelet medication is currently not generally recommended for routine prophylactic therapy.

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Relationship of serum interleukin‐7 concentration and the coagulation state in children with nephrotic syndrome

Abstract: In children with NS, serum IL-7 level increases proportionally to the elevated platelet count and other hemostatic components, but shows no correlation with serum albumin or urine protein.

Cited by 13 publications

References 22 publications

Cytokine Expression Profile of Dengue Patients at Different Phases of Illness

Cytokine Expression Profile of Dengue Patients at Different Phases of Illness

IL-7 Up-Regulates TNF-α-Dependent Osteoclastogenesis in Patients Affected by Solid Tumor

Platelet abnormalities in nephrotic syndrome

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