Relationship of serum alanine aminotransferase (ALT) to body mass index (BMI) in blood donors: the need to correct ALT for BMI in blood donor screening

Ramesh, V.; S, Saraswat; Choudhury, Nikumani; Gupta, Ranjan

doi:10.1111/j.1365-3148.1995.tb00213.x

Cited by 7 publications

(3 citation statements)

References 6 publications

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“…It is widely acknowledged that obesity is one of the most important factors responsible for elevated BP in children and adolescents ( 46 , 47 ). In accordance with a population-based study in Nigeria, where BMI and WC were revealed as risk factors for hypertension and prehypertension, we found that both general obesity and central obesity were associated factors of childhood hypertension ( 48 ).…”

Section: Discussionmentioning

confidence: 99%

Trends in Prevalence of Hypertension and Hypertension Phenotypes Among Chinese Children and Adolescents Over Two Decades (1991–2015)

Qian

Zhang

et al. 2021

Front. Cardiovasc. Med.

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Background: Hypertension is a leading cause of cardiovascular-related morbidity and mortality. Elevated blood pressure (BP) in children is related to long-term adverse health effects. Until recently, few studies have reported the secular trend and associated factors of hypertension phenotypes in Chinese children and adolescents.Methods: From the China Health and Nutrition Survey (CHNS) 1991–2015, a total of 15,143 records of children aged 7–17 years old were included. Following definitions of hypertension from the Chinese Child Blood Pressure References Collaborative Group, we estimated the prevalence of prehypertension, hypertension, stage 1 hypertension, stage 2 hypertension and its phenotypes (ISH, isolated systolic hypertension; IDH, isolated diastolic hypertension; SDH, combined systolic and diastolic hypertension). General estimation equation was used to analyze the trends in the prevalence of hypertension and hypertension phenotypes, and a multivariable logistic regression was constructed to explore the associated factors.Results: During 1991–2015, increasing trends were revealed in BP and hypertension prevalence (P < 0.001) in Chinese children and adolescents. For ISH, IDH and SDH, the age-standardized prevalence increased dramatically from 0.9 to 2.2%, from 6.2 to 14.1%, and from 1.4 to 2.9%, respectively (all P < 0.001). Adolescents aged 13–17 years (OR = 1.76, 95% CI: 1.56–1.97, P < 0.001), general obesity (OR = 2.69, 95% CI: 2.10-3.44, P < 0.001) and central obesity (OR = 1.49, 95% CI: 1.21–1.83, P < 0.001) were positively associated with hypertension, whereas the South region (OR = 0.65, 95% CI: 0.58–0.73, P < 0.001) was a negative factor. Furthermore, body mass index (BMI) and general obesity were linked to the presence of ISH, IDH and SDH. Age, waist circumference (WC) and central obesity were additionally associated with ISH, and sex, age, urban/rural setting, North/South region, WC and central obesity were additionally associated with IDH.Conclusion: BP levels and prevalence of hypertension and phenotypes increased dramatically in Chinese children and adolescents from 1991 to 2015. Regional discrepancy, demographic features, BMI, WC and overweight/obesity status were associated factors of hypertension among youths.

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Section: Discussionmentioning

confidence: 99%

Trends in Prevalence of Hypertension and Hypertension Phenotypes Among Chinese Children and Adolescents Over Two Decades (1991–2015)

Qian

Zhang

et al. 2021

Front. Cardiovasc. Med.

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“…The main reason for the lack of efficacy is that, in addition to infectious agents with liver tropism, there are other factors that may result in an increase of ALT levels, such as obesity [10–12], alcohol intake [13] and drugs. Moreover, there are extrahepatic sources of ALT, such as the muscle [14], kidney and red blood cells [15], which can result in an increase of the ALT levels in serum.…”

Section: Discussionmentioning

confidence: 99%

Alanine aminotransferase cut‐off values for blood donor screening using the new International Federation of Clinical Chemistry reference method at 37 °C

et al. 2003

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With the implementation of the new IFCC reference method for ALT determination at 37 degrees C, we propose a new ALT cut-off for blood donor screening, which, for men, is about three times the upper limit of the normal range and for women about 2.5 times. Our results show that a lower cut-off would probably not yield a higher safety of blood products in terms of detecting viral infections, but would result in a loss of approximately 0.75% of suitable blood donors.

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“…As such, a great number of donors are deferred because of elevated ALT levels (Kim et al, 2008). However, the efficiency of ALT testing to reduce hepatitis transmission is controversial because there are many other causes of elevated serum ALT levels (Bizzaro et al, 1992;Ramesh et al, 1995). Serological testing for the detection of antibodies to certain viruses is used to confirm infection.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of hepatitis A viral RNA and antibodies among Chinese blood donors

Sun

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Like other developing countries, China was reported to have a relatively high seroprevalence of anti-hepatitis A antibodies (anti-HAV). However, no studies have evaluated the prevalence of anti-HAV and HAV RNA among voluntary blood donors with or without elevated serum alanine transaminase (ALT) levels. Anti-HAV antibodies were detected using an enzyme-linked immunosorbent assay, and reverse transcription quantitative polymerase chain reaction was carried out for detection of HAV RNA. In the current study, we analyzed a total of 450 serum samples with elevated ALT levels (≥40 U/L) and 278 serum samples with non-elevated ALT levels. Seroprevalence rates of anti-HAV were 51.6% in donors with elevated ALT and 41.4% in donors with non-elevated ALT; however, none of the samples was positive for HAV RNA. The results of our study showed lower seroprevalence rates of anti-HAV in blood donors (irrespective of ALT levels) than those in published data on Chinese populations. Although donors with elevated ALT had statistically higher prevalence rates of anti-HAV than did those with non-elevated ALT, none of the serum samples had detectable levels of the active virus. In conclusion, our results demonstrate that the transmission of hepatitis A by blood transfusion will occur rarely.

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Relationship of serum alanine aminotransferase (ALT) to body mass index (BMI) in blood donors: the need to correct ALT for BMI in blood donor screening

Cited by 7 publications

References 6 publications

Trends in Prevalence of Hypertension and Hypertension Phenotypes Among Chinese Children and Adolescents Over Two Decades (1991–2015)

Trends in Prevalence of Hypertension and Hypertension Phenotypes Among Chinese Children and Adolescents Over Two Decades (1991–2015)

Alanine aminotransferase cut‐off values for blood donor screening using the new International Federation of Clinical Chemistry reference method at 37 °C

Prevalence of hepatitis A viral RNA and antibodies among Chinese blood donors

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