Relationship of serum adiponectin and resistin levels with the severity of liver fibrosis in patients with chronic hepatitis B

Čustović, Nerma; Rašić, Senija

doi:10.5937/jomb0-33793

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…The value of t 1/2 is calculated from CL and Vd. Various factors can affect LID Vd such as fluid balance including a presence of ascites and its degree, impaired level of proteins and protein/tissue binding, while LID CL is dependent on blood flow excluding protein level, and intrinsic clearance [3] [25] . Figure 2 suggests that there are differences in the metabolic function of liver in relation to the pathophysiological status of liver presented as different diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Lidocaine clearance as pharmacokinetic parameter of metabolic hepatic activity in patients with impaired liver

Jovanović¹,

Kovačević²,

Kovačević³

et al. 2023

J Med Biochemistry

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Background The study aimed to estimate lidocaine (LID) pharmacokinetic parameter values in patients with impaired liver function, and to assess change in parameters related to the surgical intervention. Methods Patients with impaired liver function were subject to the test prior to, 3 and 7 days after the intervention. LID was administered in single i.v. dose of 1 mg/kg. Blood samples were collected at 15, 30 and 90 minutes after drug administration. Non-compartmental analysis was applied for calculating the pharmacokinetic parameters. Results The study included 17 patients with the diagnosis of cirrhosis and 41 patients with liver tumor. In both groups of patients, the values of the coefficients of correlation show the best correlation between CL and Child-Pugh score (-0.693, p<0.005) over other pharmacokinetic parameters. The results indicate worsening hepatic function on 3rd day after operation in comparison to the values of LID CL prior to operation (mean LID CL for patients with Child-Pugh class A are 25.91 L/h, 41.59 L/h, respectively; while for B class are 16.89 L/h, 22.65 L/h, respectively). On day 7th, the values of LID CL (mean value for patients with Child-Pugh class A and B are 40.98 L/h and 21.46 L/h, respectively) are increased in comparison to 3rd day after. Conclusions LID pharmacokinetic parameters consequently changed according to the severity of liver impairment, assessed by Child-Pugh score. Values of LID CL and Vd coupled with standard biochemical parameters may be used in obtaining the complete picture of hepatic status of patients.

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Section: Discussionmentioning

confidence: 99%

Lidocaine clearance as pharmacokinetic parameter of metabolic hepatic activity in patients with impaired liver

Jovanović¹,

Kovačević²,

Kovačević³

et al. 2023

J Med Biochemistry

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Adiponectin inhibits TGF-β1-induced skin fibroblast proliferation and phenotype transformation via the p38 MAPK signaling pathway

et al. 2023

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The aim of this study was to investigate the effects of adiponectin (APN) on the proliferation and phenotypic transformation of human skin fibroblasts (HSFs) induced by TGF-β1. Primary fibroblast cultures were collected from prepuce surgery, and the cell viability and proliferative activity of HSFs were detected by Cell Counting Kit-8 and EdU assays. In addition, cell migration was detected by Transwell assay. The protein levels of related genes in HSF were detected by Western blotting. The results showed that the proliferation and migration abilities of HSF in the TGF-β1 group were significantly improved, and the relative protein expression levels of PCNA, α-SMA, and Collagen I in the TGF-β1 group were greatly increased. Furthermore, TGF-β1 stimulated the phosphorylation of p38 in HSF, while APN pretreatment significantly inhibited the TGF-β1-induced phosphorylation of p38. Additionally, blocking the p38 MAPK signaling pathway relieved the injury in the HSF induced by TGF-β1 and enhanced the therapeutic effect of APN in the TGF-β1-treated HSF. In conclusion, APN inhibits TGF-β1-induced HSF proliferation and myofibroblast phenotypic transformation by activating the p38 MAPK signaling pathway. APN is expected to become a potential target for preventing and treating skin fibrosis and pathological scars.

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Adipokines and their role in acute pancreatitis

Rafaqat,

Radoman-Vujačić,

Patoulias

et al. 2024

J Med Biochemistry

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Acute pancreatitis (AP) is characterized by an inflammatory response that leads to edema and haemorrhaging of pancreatic tissue. In severe cases, it can even result in the necrosis of pancreatic tissue following activation within the pancreas. Adipokines are biologically active molecules released by adipose tissue that have a wide-ranging impact on health and disease. Adipokines are cytokines produced not only in white adipose tissue but also in the fat surrounding the pancreas, and they play a role in the body's inflammatory response. The presence of increased adipose tissue, often associated with obesity, has been linked to a heightened systemic inflammatory response in cases of AP. According to the literature, there are many adipokines. This article summarizes the role of adipokines in AP. Adipokines could be the promising biomarkers for both diagnostic and new therapeutic treatment strategies in AP. However, a deeper knowledge of signaling pathways of adipokines and its potential therapeutic role in AP is necessary.

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Relationship of serum adiponectin and resistin levels with the severity of liver fibrosis in patients with chronic hepatitis B

Cited by 3 publications

References 24 publications

Lidocaine clearance as pharmacokinetic parameter of metabolic hepatic activity in patients with impaired liver

Lidocaine clearance as pharmacokinetic parameter of metabolic hepatic activity in patients with impaired liver

Adiponectin inhibits TGF-β1-induced skin fibroblast proliferation and phenotype transformation via the p38 MAPK signaling pathway

Adipokines and their role in acute pancreatitis

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