Abstract:Background The study aimed to estimate lidocaine (LID) pharmacokinetic parameter values in patients with impaired liver function, and to assess change in parameters related to the surgical intervention.
Methods Patients with impaired liver function were subject to the test prior to, 3 and 7 days after the intervention. LID was administered in single i.v. dose of 1 mg/kg. Blood samples were collected at 15, 30 and 90 minutes after drug administration. Non-compartmental analysis was applied for calculating… Show more
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