Relationship of Relaxin Hormone and Thumb Carpometacarpal Joint Arthritis

Wolf, Jennifer Moriatis; Scher, David M.; Etchill, Eric W.; Scott, Frank; Williams, Allison; Delaronde, Steven; King, Karen B.

doi:10.1007/s11999-013-2960-4

Cited by 37 publications

(25 citation statements)

References 48 publications

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“…The dependent variable was a binary variable of whether the patient was in the early OA group or the control group. Advanced age, female sex, and increased BMI were previously identified as factors associated with CMC OA, [2,6,16,30] and were controlled for in the adjusted analysis.…”

Section: Methodsmentioning

confidence: 99%

“…Patients with early CMC OA typically have weakness on the affected hand when pinching, grasping, or twisting objects [26][27][28]. Studies support an association of advanced age, female sex, family history, and increased BMI with CMC OA [2,6,16,30]. Pinching tasks are especially uncomfortable for patients with early OA, and patients with CMC and distal interphalangeal arthritis have been shown to have lower pinch and grip strength [1,5,8,17,24].…”

Section: Introductionmentioning

confidence: 99%

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Weaker Functional Pinch Strength Is Associated With Early Thumb Carpometacarpal Osteoarthritis

McQuillan

Kenney

Crisco

et al. 2016

Clinical Orthopaedics &Amp; Related Research

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Background The thumb carpometacarpal (CMC) joint orchestrates pinch in its various positions, and thumb CMC osteoarthritis (OA) is a major source of orthopaedic morbidity. Self-reported pain, weakness, and physical examination may not correspond to radiographic findings when diagnosing early thumb CMC OA. Weakness is a prominent feature of the disease, but little evidence exists to quantify self-reported loss of strength with time, or to compare weakness with that of a nonarthritic population during early disease. Questions/purposes We asked: (1) Is pinch strength in subjects with early thumb CMC OA less than that in asymptomatic control subjects; and (2) weakness in which pinch position (key, tripod, or tip pinch) has the strongest association with early OA diagnosis? Methods For this case-control study, we recruited 23 subjects who were asymptomatic and 91 with early OA for comprehensive history, physical examination, strength measurements, pain surveys, and radiographic evaluation. We used multivariate logistic regression to quantify the association between declining pinch strength and early OA diagnosis after controlling for age, sex, and BMI. This analysis was performed for three different pinch positions (key, tripod, and tip pinch) to evaluate which measurement was most closely associated with diagnosis. Results Pinch strength was less in patients with early thumb CMC OA. Key pinch had the most robust association with OA diagnosis, in which a 20% decrease in key pinch strength from the control subjects' baseline was associated with a 10% increase in the OA diagnosis (95% CI, 3%-16%; p = 0.004). This had a stronger association with OA diagnosis than tip pinch, in which a 20% decrease in strength was associated with a 6% increase in early CMC OA (95% CI, 1.0%-11%; p = 0.031). Tripod pinch also was associated to a lesser extent; a 20% reduction in tripod pinch led to a 5% increase in OA (95% CI, 1.3%-9%; p = 0.048). Conclusions Decreasing pinch strength, especially key pinch, is associated with early CMC arthritis before the development of extensive radiographic disease.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Weaker Functional Pinch Strength Is Associated With Early Thumb Carpometacarpal Osteoarthritis

McQuillan

Kenney

Crisco

et al. 2016

Clinical Orthopaedics &Amp; Related Research

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“…215,216 This may be particularly important when documenting relaxin exposure. Because relaxin rises and peaks during a relatively short window (6-10 days) after ovulation based on other hormonal events, [217][218][219][220] we do not know if the high proportion of undetectable levels within a single sample (as high as 64%-80%) [221][222][223][224] is due to timing or suggests that only a subset of females are exposed to appreciable relaxin levels due to mediating factors. 219,221,225 5.…”

Section: Good Evidence Demonstrates That Some (But Not All)mentioning

confidence: 99%

ACL Research Retreat VII: An Update on Anterior Cruciate Ligament Injury Risk Factor Identification, Screening, and Prevention

Shultz

Schmitz

Benjaminse

et al. 2015

Journal of Athletic Training

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“…The first CMC ligament reconstruction technique (Eaton and Littler, 1973) and the subsequent ligament reconstruction tendon interposition (LRTI) (Eaton et al, 1984; Freedman et al, 2000; Tomaino et al, 1995) were partly based on the theory that the CMC joint is kept intact primarily by the AOL. Additionally, the presence of the hormone relaxin, which is associated with ligament loosening, has been found in this ligament and has been correlated with joint laxity (Lubahn et al, 2006; Wolf et al, 2013a, 2013b). Recent studies, however, have reported structural limitations of the AOL that challenge the importance of its role on joint stability (Colman et al, 2007; Hagert et al, 2012; Ladd et al, 2012; Lin et al, 2013; Strauch et al, 1999).…”

Section: Introductionmentioning

confidence: 95%

In vivo recruitment patterns in the anterior oblique and dorsoradial ligaments of the first carpometacarpal joint

Halilaj

Rainbow

Moore

et al. 2015

Journal of Biomechanics

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The anterior oblique ligament (AOL) and the dorsoradial ligament (DRL) are both regarded as mechanical stabilizers of the thumb carpometacarpal (CMC) joint, which in older women is often affected by osteoarthritis. Inferences on the potential relationship of these ligaments to joint pathomechanics are based on clinical experience and studies of cadaveric tissue, but their function has been studied sparsely in vivo. The purpose of this study was to gain insight into the functions of the AOL and DRL using in vivo joint kinematic data. The thumbs of 44 healthy subjects were imaged with a clinical computed tomography scanner in functional-task and thumb range-of-motion positions. The origins and insertion sites of the AOL and the DRL were identified on the 3D bone models and each ligament was modeled as a set of three fibers whose lengths were the minimum distances between insertion sites. Ligament recruitment, which represented ligament length as a percentage of the maximum length across the scanned positions, was computed for each position and related to joint posture. Mean AOL recruitment was lower than 91% across the CMC range of motion, whereas mean DRL recruitment was generally higher than 91% in abduction and flexion. Under the assumption that ligaments do not strain by more than 10% physiologically, our findings of mean ligament recruitments across the CMC range of motion indicate that the AOL is likely slack during most physiological positions, whereas the DRL may be taut and therefore support the joint in positions of CMC joint abduction and flexion.

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Relationship of Relaxin Hormone and Thumb Carpometacarpal Joint Arthritis

Cited by 37 publications

References 48 publications

Weaker Functional Pinch Strength Is Associated With Early Thumb Carpometacarpal Osteoarthritis

Weaker Functional Pinch Strength Is Associated With Early Thumb Carpometacarpal Osteoarthritis

ACL Research Retreat VII: An Update on Anterior Cruciate Ligament Injury Risk Factor Identification, Screening, and Prevention

In vivo recruitment patterns in the anterior oblique and dorsoradial ligaments of the first carpometacarpal joint

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