Relationship of plasma levels of estradiol to the severity of coronary arteriosclerosis

Takeda, Ryuji; Ikeda, M.; Miyamori, Isamu; マツバラ, タカシ; Okamoto, Shoji; Koshida, Hikaru; Morise, Toshio; Nunoda, S; Nakayama, Akira; Genda, Akira

doi:10.1016/0021-9150(87)90107-9

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…This observation was confirmed by a number of subsequent studies [7, 8, 9, 10, 11]. Early clinical trials suggested that the administration of estrogens to men with prostate cancer [12]and male survivors of myocardial infarction [13]might be associated with increased risk of CAD.…”

Section: Introductionsupporting

confidence: 60%

“…Cauley et al [21]and Slowinska-Srzednicka et al [22]found normal testosterone levels in frozen blood samples taken many years earlier from men who subsequently died from myocardial infarction. Several studies measuring testosterone levels in patients with CAD revealed by angiography found normal levels [3, 9, 11, 23], whereas others indicated decreased levels [14, 24, 25]. Levin et al [26]found normal levels of testosterone in men with angina pectoris, whereas Aksut et al [27]reported low levels.…”

Section: Discussionmentioning

confidence: 99%

“…A large number of epidemiological and clinical studies have suggested that hyperestrogenemia predisposes to atherosclerosis in men [6, 7, 8, 9, 11, 17, 18, 19, 20]; however, there are also several studies which failed to detect alterations of sex hormone concentrations, mainly of estradiol, in CAD [2, 3, 14, 15]. Studies suggest that estradiol levels rise within 72 h of the onset of stress, but subsequently decline rapidly.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between Endogenous Sex Hormone Levels, Lipoproteins and Coronary Atherosclerosis in Men Undergoing Coronary Angiography

et al. 1999

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This study was carried out in order to investigate the relationship between endogenous sex steroid hormones and coronary artery disease (CAD). Three hundred and thirty-seven men undergoing coronary angiography were enrolled in the study. Total testosterone, estradiol, free testosterone levels in men with CAD (n = 213) were compared to those of men without CAD (n = 124). No significant differences were found in the serum concentrations of estradiol, total and free testosterone and serum lipid profile between the two groups. Total and free testosterone were negatively (p < 0.05 to p < 0.001) and estradiol was positively (p < 0.05) correlated with age in both groups. Total cholesterol and low-density-lipoprotein levels were positively correlated with the level of free testosterone (r = 0.221, p < 0.01; r = 0.173, p < 0.05, respectively), and high-density-lipoprotein levels were negatively correlated with total testosterone in patients with CAD (r = –0.166, p < 0.05). The results of this study do not support the role of sex steroid hormones in CAD. However, the relationship between sex steroids and serum lipids needs further clarification.

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Section: Introductionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Relationship between Endogenous Sex Hormone Levels, Lipoproteins and Coronary Atherosclerosis in Men Undergoing Coronary Angiography

et al. 1999

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“…English et al showed decreased levels of oestrogens in patients with coronary artery disease, a result which is contradictory to the results of most published studies, including ours which reported either normal or moderately increased oestrogen concentrations in patients with coronary artery disease [2,[10][11][12][13][14] . We believe that their result is mostly due to methodological problems.…”

Section: Men With Coronary Artery Disease Have Lower Levels Of Androgcontrasting

confidence: 97%

Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms

Yildirir

Kabakçı

Can

et al. 2001

European Heart Journal

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“…1) estrogen levels in the body decreased significantly after menopause with women, while estrogen could increase endothelial cell-mediated dilation and delay the formation of arteriosclerosis; [29,30] 2) at the same time, the diameter of coronary artery in women is smaller than that in men, [31] so the stent placement would be relatively more damaging to blood vessels. Our study found that the risk of restenosis increased by 109%, 27%, and 121% for each additional stent of delayed PCI, NSTE-ACS and Stable angina.…”

Section: Discussionmentioning

confidence: 99%

The number of stents was an independent risk of stent restenosis in patients undergoing percutaneous coronary intervention

Tang¹,

Cui

Liu³

et al. 2019

Medicine

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Percutaneous coronary intervention (PCI) is one of the most effective therapies for coronary artery disease, but stent restenosis remains an important clinical challenge. The studies about the independent effect of the number of stents on stent restenosis were limited.The purpose was to identify the independent effect of the number of stents on stent restenosis.A retrospective cohort study of data reuse.From July 2009 to August 2011, a total of 2338 cases met the inclusion and exclusion criteria.The univariate analysis showed that the number of stents was a risk of stent restenosis, the OR value was 1.30 (95% CI:1.15 to 1.47, P < .001). The multi-factor regression analysis also showed that the number of stents was an independent risk of stent restenosis, the adjusted OR value was 1.38 (95% CI: 1.15 to 1.66, P < .001).Compared with 1-2 stents, the adjusted OR values of 3-5 stents and more than 6 stents were respectively 2.20 (95% CI: 1.24 to 3.90, P = .007) and 5.33 (95% CI: 1.89 to 15.08, P = .002), and the trend adjusted OR values was 2.26 (95% CI: 1.43 to 3.59, P < .001).The subgroup analysis of multi-factor regression analysis showed that when patients with the following conditions: 50 < Age, female, non-DES or SES, the risk of stent restenosis increased obviously.The number of stents was an independent risk of stent restenosis in patients undergoing PCI, especially for patients with the following conditions: 2

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Relationship of plasma levels of estradiol to the severity of coronary arteriosclerosis

Cited by 6 publications

References 9 publications

Relationship between Endogenous Sex Hormone Levels, Lipoproteins and Coronary Atherosclerosis in Men Undergoing Coronary Angiography

Relationship between Endogenous Sex Hormone Levels, Lipoproteins and Coronary Atherosclerosis in Men Undergoing Coronary Angiography

Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms

The number of stents was an independent risk of stent restenosis in patients undergoing percutaneous coronary intervention

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