The number of stents was an independent risk of stent restenosis in patients undergoing percutaneous coronary intervention

Tang, Long; Cui, Qianwei; Liu, Danping; Fu, Yingying

doi:10.1097/md.0000000000018312

Cited by 14 publications

(8 citation statements)

References 33 publications

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“…In previous reports, several risk factors were related to ISR, including diabetes, chronic renal insufficiency, bare-metal stents, small coronary artery vessels, a long stent length, and coronary bifurcation lesions [ 4 , 12 ]. Recently, studies revealed that the increase of C-reactive protein, homocysteine, and stent numbers are risk factors for ISR [ 13 – 15 ]. However, the roles of platelet parameters in ISR were still less reported.…”

Section: Introductionmentioning

confidence: 99%

A prediction model based on platelet parameters, lipid levels, and angiographic characteristics to predict in-stent restenosis in coronary artery disease patients implanted with drug-eluting stents

et al. 2021

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Background The present study was aimed to establish a prediction model for in-stent restenosis (ISR) in subjects who had undergone percutaneous coronary intervention (PCI) with drug-eluting stents (DESs). Materials and methods A retrospective cohort study was conducted. From September 2010 to September 2013, we included 968 subjects who had received coronary follow-up angiography after primary PCI. The logistic regression analysis, receiver operator characteristic (ROC) analysis, nomogram analysis, Hosmer–Lemeshow χ2 statistic, and calibration curve were applied to build and evaluate the prediction model. Results Fifty-six patients (5.79%) occurred ISR. The platelet distribution width (PDW), total cholesterol (TC), systolic blood pressure (SBP), low-density lipoprotein cholesterol (LDL-C), and lesion vessels had significant differences between ISR and non-ISR groups (all P < 0.05). And these variables were independently associated with ISR (all P < 0.05). Furthermore, they were identified as predictors (all AUC > 0.5 and P < 0.05) to establish a prediction model. The prediction model showed a good value of area under curve (AUC) (95%CI): 0.72 (0.64–0.80), and its optimized cut-off was 6.39 with 71% sensitivity and 65% specificity to predict ISR. Conclusion The incidence of ISR is 5.79% in CAD patients with DES implantation in the Xinjiang population, China. The prediction model based on PDW, SBP, TC, LDL-C, and lesion vessels was an effective model to predict ISR in CAD patients with DESs implantation.

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Section: Introductionmentioning

confidence: 99%

A prediction model based on platelet parameters, lipid levels, and angiographic characteristics to predict in-stent restenosis in coronary artery disease patients implanted with drug-eluting stents

et al. 2021

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“…Although some investigators have reported a higher risk of restenosis in male patients than in females, the data are not consistent [25,26].…”

Section: Discussionmentioning

confidence: 99%

Single-nucleotide polymorphism of ADRβ2 and CDKN1B genes in Egyptian patients with coronary artery in-stent restenosis

Abdelaziz

Mohamed

Gad

et al. 2022

Coronary Artery Disease

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BackgroundIn-stent restenosis is a common complication after percutaneous coronary intervention. The purpose of the current study is to look for associations of genetic variation in adrenergic beta-2 receptor (ADRβ2), and cyclin-dependent kinase inhibitor 1B (CDKN1B) genes in patients diagnosed with in-stent restenosis (ISR) after percutaneous coronary intervention in the Egyptians.Methods Polymorphisms in ADRβ2 and CDKN1B were determined using PCR-restriction fragment length polymorphism in 200 Egyptian patients who underwent coronary angioplasty and stent placement of whom 100 patients developed ISR. ResultsWe found that the GG genotype of ADRβ2 and CC genotype of CDKN1B were more likely to develop restenosis after stenting (odds ratio = 3.7 and 3.2; P = 0.001, respectively). Our study considered that male sex, diabetes, obesity, bare-metal stents type of implanted stents, longer stents, GG genotype of ADRβ2, and CC genotype of CDK1B were significant independent predictors for ISR. Conclusion our resultsindicate that ADRβ2 (rs1042713) and CDKN1B (rs36228499) could be associated with the development of ISR in Egyptians.

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“…Some studies have investigated the role of size and location of calcification regarding the restenosis rate after surgical treatment. Compared with the low percentage of restenosis after coronary drug-eluted stent replacement (10-15%) (12), restenosis after lower limb artery stenting reaches 40-50% (13,14), while the variable rate of this complication is between 1 and 36% after intervention at the carotid level (15).…”

Section: Introductionmentioning

confidence: 93%

Calcification patterns in femoral and carotid atheromatous plaques: A comparative morphometric study

et al. 2021

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This comparative study was designed to focus on the mineral patterns in human atherosclerotic plaques based on quantitative measurements of calcium deposits through the morphometric method. A total of 101 atherosclerotic plaques were harvested by conventional transluminal angioplasty from the carotid artery (CA) and different segments of the femoral-popliteal axis (FPA), fixed in formalin and sent for histological processing. The histological grade of the atherosclerotic plaque and the calcification pattern were evaluated, followed by a morphometric analysis of the mineral deposits. Regarding the localization, the advanced plaques (VII and VIII types) developed predominantly at the level of the superficial femoral artery (SFA) compared to the CA (P<0.001). This significant difference was maintained even if they were divided into low grade (IV and V) and high grade categories (VI, VII and VIII) (P<0.05). Compared with that in the carotid plaques, in the FPA plaques the mineralized surface increased in parallel with the narrowing of the vascular lumen diameter. The image analysis of the total pathological calcification score (pCS) showed a significant difference between the CA plaques and distal SFA (dSFA) plaques (P= 0.038) and between the proximal SFA (pSFA) and dSFA plaques (P= 0.013). In the case of the simple nodular pattern, calcification occupied significantly larger areas in the plaques developed in the dSFA and popliteal artery (PA) in comparison with the CA plaques (P= 0.0007 and P= 0.0009). pCSs calculated in plaques with extensive calcification pattern showed a lower value in the CA vs. the pSFA plaques (P= 0.004). A less pronounced, but significant difference was observed between the pCS of pSFA and dSFA plaques (P= 0.017). Femoral and carotid plaques exhibited different morphology and tendency for calcification. In parallel with the narrowing of the vascular lumen diameter, the mineralized surface increased at the level of different FPA segments. These results suggest that the mechanism is site-specific, and wall structure-dependent.

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The number of stents was an independent risk of stent restenosis in patients undergoing percutaneous coronary intervention

Cited by 14 publications

References 33 publications

A prediction model based on platelet parameters, lipid levels, and angiographic characteristics to predict in-stent restenosis in coronary artery disease patients implanted with drug-eluting stents

A prediction model based on platelet parameters, lipid levels, and angiographic characteristics to predict in-stent restenosis in coronary artery disease patients implanted with drug-eluting stents

Single-nucleotide polymorphism of ADRβ2 and CDKN1B genes in Egyptian patients with coronary artery in-stent restenosis

Calcification patterns in femoral and carotid atheromatous plaques: A comparative morphometric study

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