Relationship of parasagittal bands of acetylcholinesterase activity to the climbing fiber representation

Robertson, Lee T.; Logan, Kay

doi:10.1016/0304-3940(86)90067-4

Cited by 13 publications

(4 citation statements)

References 9 publications

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“…The histochemical protocol used in this study has been shown to provide reliable staining of AChE ac tivity in the cerebellum of domestic cats [Brodal and Kawamura, 1980;Robertson and Logan, 1986] as well as in other regions of the nervous system [Geneser, 1986[Geneser, , 1987, and the general distribution of the AChE activity appears to be similar to results of Hess and Voogd [1986]. However, Hess and Voogd ob served a more detailed pattern of bands of reactive glomeruli than was evident in the present results.…”

Section: Hiv Hv Hvi CLsupporting

confidence: 58%

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Distribution of Acetylcholinesterase in the Granular Layer of the Cerebellum of the Rhesus Monkey (Macaca mulatta)

Robertson¹,

Roman²

1989

Brain Behav Evol

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A nonuniform distribution of acetylcholinesterase (AChE) activity was identified in the granular layer of the cerebellum in rhesus monkeys. The distribution of darkly AChE-stained clumps in the granular layer was determined for each lobule of the vermis and the lateral cortex. The vermis contained a greater density of AChE reaction product than the lateral cortex. In the vermis, lobules IX and X had significantly the highest level of activity, followed by lobules VII and VIII, which were significantly higher than lobules II-VI. In the lateral cortex, the flocculus had the highest level of the AChE activity, followed by crus I and the dorsal paraflocculus, which had significantly higher levels than the remaining lobules. The high levels of AChE activity in the flocculonodular lobe and lobule IX may correspond to cholinergic mossy fiber transmission, but the high levels of AChE activity in other cerebellar regions probably involve noncholinergic functions. The significance of the nonuniform AChE distribution is not yet known, but may correspond to regional differences in neuronal or metabolic activity in the cerebellum that occur in conjunction with specific behaviors.

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Section: Hiv Hv Hvi CLsupporting

confidence: 58%

“…The borders of these bands correspond to the parasagittal distribution of the olivocerebellar and corticonuclear projections (see reviews by Brodal and Kawamura [1980], Voogd and Bigare, 1980]). Some of these bands correspond to different functional zones [Robertson and Logan, 1986].…”

Section: Introductionmentioning

confidence: 99%

Distribution of Acetylcholinesterase in the Granular Layer of the Cerebellum of the Rhesus Monkey (Macaca mulatta)

Robertson¹,

Roman²

1989

Brain Behav Evol

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“…Previous reports have identified similar subpopulations of cerebellar Purkinje cells containing GABA and/or motilin (ChanPalay et al, 1981;Chan-Palay, 1983) or bands of Purkinje cells positively and negatively stained with monoclonal antibodies raised against a component of a cerebellar homogenate (Hawkes et al, 1985). Longitudinal patterns of climbing fiber projections (Groenewegen and Voogd, 1976;Oscarsson, 1976;Voogd et al, 1985;Logan and Robertson, 1986;Robertson and Logan, 1986), mossy fiber projections (Oscarsson, 1976;Voogd et al, 1985) Purkinje cell axons (Feirbend et al, 1976), and acetylcholinesterase (Hess and Voogd, 1986;Robertson and Logan, 1986), and cytochrome oxidase (Hess and Voogd, 1986) localizations exist in the cerebellum. The relationship between the subpopulation of taurine neurons identified in this study and other longitudinal cerebellar patterns remains to be determined.…”

Section: Discussionmentioning

confidence: 87%

Colocalization of taurine- and cysteine sulfinic acid decarboxylase- like immunoreactivity in the cerebellum of the rat with monoclonal antibodies against taurine

et al. 1988

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Two monoclonal antibodies against fixative-modified taurine, Tau1 and Tau2, were produced, characterized, and used in the present study to analyze the distribution of taurine in the cerebellum of the rat. In addition, immunohistochemical colocalization experiments were performed to determine whether cerebellar neurons contain both taurine and its synthesizing enzyme, cysteine sulfinic acid decarboxylase (CSADC). In ELISAs, both Tau1 and Tau2 displayed high affinities for taurine conjugated to various carrier proteins and possessed some cross- reactivity for other amino acids which are present in lower concentrations in the brain than taurine. Tau2 was found to recognize only taurine and hypotaurine when paraformaldehyde was used to fix the amino acids to carrier proteins. With the use of glutaraldehyde fixation, Tau1 cross-reacted with conjugates of beta-alanine and hypotaurine and Tau2 cross-reacted strongly with conjugates of cysteic acid and hypotaurine and weakly with cysteine sulfinic acid. Despite different cross-reactivities, Tau1 and Tau2 exhibited almost identical patterns of neuronal staining in bands of Purkinje cells in the cerebellum. Staining of Purkinje cell dendrites was more prominent than staining of the soma. Light immunoreactivity was present in Golgi, stellate, and basket cells. A scattered population of granule cells displayed taurine-like immunoreactivity at the electron microscopic level. Immunostaining was identified in some terminals in the Purkinje cell layer and in a limited number of mossy fibers. Tau2-like immunoreactivity was colocalized with CSADC-like immunoreactivity in the cerebellar neurons described above. These immunoreactive cells may represent a subpopulation of neurons that contain a higher concentration of taurine than neighboring cells due to their ability to synthesize taurine. The intense immunoreactive staining of Purkinje cell dendrites provides support for the hypothesis that calcium- dependent release of taurine in the cerebellum may originate primarily from dendritic rather than synaptic processes and suggests a neuromodulator role for taurine in the cerebellum.

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“…Chambers & Sprague, 1955;Ito, 1984). Anatomically and functionally defined compartments comprising rostrocaudal and mediolateral cortical bands have been identified which link the cerebellar cortex to both afferent and efferent systems (Chambers & Sprague, 1955;Marani & Voogd, 1977;Robertson & Logan, 1986;Voogd et al, 1987;Welker, 1987;Lou & Bloedel, 1992;Leclerc et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

Spatial organization of proprioception in the cat spinocerebellum. Purkinje cell responses to passive foot rotation

Perciavalle

Bosco

Poppele

1998

European Journal of Neuroscience

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This study examines the spinocerebellar locations of Purkinje cells that responded to passive foot rotations at the ankle joint in anaesthetized cats. Using a novel approach for mapping the locations of recorded cells from several animals onto an unfolded two-dimensional representation of the cortex, we found that cells distributed throughout the anterior-posterior extent of the spinocerebellar cortex, except in the most medial parts corresponding to zones a and b, were responsive to ankle joint rotation. The cell distributions revealed a clustering according to their response amplitudes, which showed evidence for both parasagittal and transverse banding.

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Relationship of parasagittal bands of acetylcholinesterase activity to the climbing fiber representation

Cited by 13 publications

References 9 publications

Distribution of Acetylcholinesterase in the Granular Layer of the Cerebellum of the Rhesus Monkey <i>(Macaca mulatta</i><i>)</i>

Distribution of Acetylcholinesterase in the Granular Layer of the Cerebellum of the Rhesus Monkey <i>(Macaca mulatta</i><i>)</i>

Colocalization of taurine- and cysteine sulfinic acid decarboxylase- like immunoreactivity in the cerebellum of the rat with monoclonal antibodies against taurine

Spatial organization of proprioception in the cat spinocerebellum. Purkinje cell responses to passive foot rotation

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