Spatial organization of proprioception in the cat spinocerebellum. Purkinje cell responses to passive foot rotation

Perciavalle, Vincenzo; Bosco, Gianfranco; Poppele, R. E.

doi:10.1046/j.1460-9568.1998.00212.x

Cited by 12 publications

(6 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The compartmental organization of spinocerebellar mossy fibers is a classic model for studying mossy fiber topography because its termination pattern clearly illustrates the degree to which cerebellar afferents are organized at the structural (Voogd et al, 1969; Arsenio Nunes and Sotelo, 1985; Yaginuma and Matsushita, 1989; Gravel and Hawkes, 1990; Vogel and Prittie, 1994; Reeber et al, 2011), developmental (Vig et al, 2005; Sillitoe et al, 2010; Reeber et al, 2011) and functional (Perciavalle et al, 1998; Valle et al, 2012) levels. Based upon these well-known characteristics of the pathway, we injected WGA-Alexa conjugated tracers into upper lumber-lower thoracic spinocerebellar neurons to examine the terminal field distribution of afferent fibers within ectopic Purkinje cells in scrambler mutants.…”

Section: Resultsmentioning

confidence: 99%

Establishment of topographic circuit zones in the cerebellum of scrambler mutant mice

Reeber¹,

Loeschel²,

Franklin³

et al. 2013

Front. Neural Circuits

View full text Add to dashboard Cite

The cerebellum is organized into zonal circuits that are thought to regulate ongoing motor behavior. Recent studies suggest that neuronal birthdates, gene expression patterning, and apoptosis control zone formation. Importantly, developing Purkinje cell zones are thought to provide the framework upon which afferent circuitry is organized. Yet, it is not clear whether altering the final placement of Purkinje cells affects the assembly of circuits into topographic zones. To gain insight into this problem, we examined zonal connectivity in scrambler mice; spontaneous mutants that have severe Purkinje cell ectopia due to the loss of reelin-disabled1 signaling. We used immunohistochemistry and neural tracing to determine whether displacement of Purkinje cell zones into ectopic positions triggers defects in zonal connectivity within sensory-motor circuits. Despite the abnormal placement of more than 95% of Purkinje cells in scrambler mice, the complementary relationship between molecularly distinct Purkinje cell zones is maintained, and consequently, afferents are targeted into topographic circuits. These data suggest that although loss of disabled1 distorts the Purkinje cell map, its absence does not obstruct the formation of zonal circuits. These findings support the hypothesis that Purkinje cell zones play an essential role in establishing afferent topography.

show abstract

Section: Resultsmentioning

confidence: 99%

Establishment of topographic circuit zones in the cerebellum of scrambler mutant mice

Reeber¹,

Loeschel²,

Franklin³

et al. 2013

Front. Neural Circuits

View full text Add to dashboard Cite

show abstract

“…Some of these differences could be explained by the variability in positioning of the slices between rats and by the volume effects due to the relatively thick slices (1 mm, which is also the most likely cause of differences between the sagittal and coronal images), but it is likely that genuine differences were present between individual rats. Most of these differences may be caused by the normal variability in the gross anatomy of the brain, which is already obvious when the two rat brains shown in Figs 4 and 5(e) ach are compared [see also Perciavalle et al . (1998) for variability in sizes of the cat cerebellum and Steinmetz & Seitz (1991), Woods et al .…”

Section: Discussionmentioning

confidence: 99%

A patchy horizontal organization of the somatosensory activation of the rat cerebellum demonstrated by functional MRI

Peeters¹,

Verhoye²,

Vos³

et al. 1999

Eur J of Neuroscience

View full text Add to dashboard Cite

Blood oxygenation level dependent contrast (BOLD) functional MRI (fMRI) responses, in a 7-T magnet, were observed in the cerebellum of alpha-chloralose anaesthetized rats in response to innocuous electrical stimulation of a forepaw or hindpaw. The responses were imaged in both coronal and sagittal slices which allowed for a clear delineation and localization of the observed activations. We demonstrate the validity of our fMRI protocol by imaging the responses in somatosensory cortex to the same stimuli and by showing reproducibility of the cerebellar responses. Widespread bilateral activations were found with mainly a patchy and mediolateral band organization, more pronounced ipsilaterally. Possible parasagittal bands were observed only in contralateral lobule VI. There was no overlap between the cerebellar activations caused by forepaw and hindpaw stimuli. The overall horizontal organization of these responses was quite remarkable. For both stimulation paradigms most of the activation patches were positioned in either a rostral or caudal broad plane running anteroposteriorly through both anterior and posterior cerebellum. The rostral planes were completely separated, with the forepaw activation closer to the surface, while the caudal plane was common to both stimulation protocols. We relate our findings to the known projection patterns of spinocerebellar and cuneocerebellar mossy fibres, and to human fMRI studies.

show abstract

“…Interestingly, these biases in Purkinje cell movement-related activity have been described mainly for whole-arm movements, whereas other studies that examined cerebellar sensory information processing in the context of single-joint movements pointed out a larger variety of Purkinje cell response patterns (e.g. Kolb & Rubia, 1980;Bauswein et al, 1983;Gray et al, 1993;Perciavalle et al, 1998). However, a possible explanation for this incongruence is that single joint movements recruit only part of the sensory-and motorrelated inputs to the cerebellar cortex not allowing therefore the type of transformation of sensory (or sensori-motor) information that might produce response biases across the cerebellar cortex.…”

Section: Response Patterns To Passive Arm Movementsmentioning

confidence: 99%

“…In principle, this type of organization might represent a valid framework for the organization of proprioceptive information. In a recent study, Perciavalle et al (1998) mapped Purkinje cells responses to passive¯exion/extension movements of the cat's ankle and found that neurons responding to ankle movements were intercalated with others that did not respond. The result of the present study is, in this respect, very similar.…”

Section: Mapping Arm-related Purkinje Cells In the Spinocerebellummentioning

confidence: 99%

“…A more direct investigation of spinocerebellar Purkinje cells' sensory responses to movement was undertaken by Perciavalle et al (1998) (also Gray et al, 1993 by imposing passive¯exion±extension movements to the ankle joint of anaesthetized cats. Except for a medial strip of unresponsive neurons, Purkinje cells responding to ankle¯exion-extension movements were found throughout the spinocerebellar cortex intermingled with unresponsive neurons.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Distribution of spinocerebellar Purkinje cell responses to passive forelimb movements in the rat

Bosco

Giaquinta

Valle

et al. 2000

Eur J of Neuroscience

View full text Add to dashboard Cite

We recorded Purkinje cell activity throughout the spinocerebellum of anaesthetized rats while imposing circular passive movements to the unrestrained forelimb. The aim was to understand the type of processing of sensory information occurring at the level of the cerebellar cortex, on the basis that precerebellar sensory neurons have been shown to represent whole limb movement parameters better than single joint movements. We observed that neurons representing sensory aspects of arm movements were scattered throughout the spinocerebellar cortex without a distinct segregation from those that did not respond, albeit the relative density of responsive and unresponsive neurons was quite variable and depended on the area of the cortex. Furthermore, Purkinje cells that responded significantly to the arm movement cycles all showed the same response pattern consisting of a firing rate increase during the downward extension of the arm. These results are discussed as suggesting a coordinate framework for the representation of proprioceptive information in the cerebellum congruent to that observed for encoding motor parameters.

show abstract

Spatial organization of proprioception in the cat spinocerebellum. Purkinje cell responses to passive foot rotation

Cited by 12 publications

References 41 publications

Establishment of topographic circuit zones in the cerebellum of scrambler mutant mice

Establishment of topographic circuit zones in the cerebellum of scrambler mutant mice

A patchy horizontal organization of the somatosensory activation of the rat cerebellum demonstrated by functional MRI

Distribution of spinocerebellar Purkinje cell responses to passive forelimb movements in the rat

Contact Info

Product

Resources

About