Relationship of paraoxonase-1, malondialdehyde and mean platelet volume with markers of atherosclerosis in familial Mediterranean fever: an observational study

Arıtürk, Özlem Karakurt; Üreten, Kemal; Sari, Munevver; Yazıhan, Nuray; Ermiş, Ezgi; Ergüder, Berrin İmge

doi:10.5152/akd.2013.103

Cited by 11 publications

(12 citation statements)

References 39 publications

(41 reference statements)

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“…Usefulness of MPV in assessment of atherosclerotic risk in cases with FMF was also investigated. In accordance with our results, most of the studies found significantly higher MPV values in FMF patients and stated that FMF is associated with increased risk of atherosclerosis [6,9,10]. MPV values were found higher even in attack-free FMF cases.…”

Section: Discussionsupporting

confidence: 92%

“…Carotid intima media thickness, endothelial dysfunction, MPV and EAT thickness are some parameters that suggested for evaluation of increased atherosclerotic risk [3-5,7]. Familial Mediterranean fever is an inflammatory disease suggested to predispose to atherosclerosis [4-6]. The current study has found that FMF cases had significantly higher EAT thicknesses and MPV values when compared to healthy controls and EAT thickness has correlated with age of diagnosis, duration of delay in diagnosis, and MPV values.…”

Section: Discussionmentioning

confidence: 99%

“…Case-control studies allowing evaluation of carotid intima media thickness and endothelial dysfunction found a predisposition of FMF patients to atherosclerosis [4,5]. Mean platelet volume (MPV) and epicardial adipose tissue (EAT) thickness are novel parameters used in prediction of the risk of atherosclerosis [3,6-8]. Albeit contradictory results have been reported, there are some studies investigating the usefulness of MPV in assessment of atherosclerotic risk in cases with FMF [6,9,10].…”

Section: Introductionmentioning

confidence: 99%

“…Mean platelet volume (MPV) and epicardial adipose tissue (EAT) thickness are novel parameters used in prediction of the risk of atherosclerosis [3,6-8]. Albeit contradictory results have been reported, there are some studies investigating the usefulness of MPV in assessment of atherosclerotic risk in cases with FMF [6,9,10]. However, no study evaluating EAT thicknesses of FMF patients was reported so far.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever

et al. 2015

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BackgroundFamilial Mediterranean fever (FMF) is an inflammatory disease, which is suggested to be associated with increased risk of atherosclerosis. Epicardial adipose tissue (EAT) thickness and the mean platelet volume (MPV) are parameters used in prediction of atherosclerotic risk in various conditions. These parameters were evaluated in children with FMF and compared with healthy controls.MethodsForty-five patients with FMF and 54 age- and gender-matched healthy controls were assessed. Duration of symptoms, age at diagnosis, duration of delay in diagnosis, frequency and duration of FMF attacks, disease severity scores, response to colchicine therapy, MEditerraneanFeVer (MEFV) gene mutations, and MPV values were recorded. EAT thicknesses were measured by echocardiography.ResultsEpicardial adipose tissue thicknesses of the children with FMF were found to be significantly greater than that of controls (5.1 ± 1.4 vs. 4.5 ± 0.9 mm, p = 0.036). FMF patients had significantly higher MPV values compared with the controls (7.8 ± 1.1 vs. 7.3 ± 1.4 fl, p = 0.044). Age at diagnosis, duration of delay in diagnosis, and MPV values were found to be correlated with EAT thickness in the patient group (r = 0.49, p = 0.001 for the former parameters and r = 0.32, p = 0.04 for MPV).ConclusionEpicardial adipose tissue thickness and MPV values seem to be increased in children with FMF. These findings may indicate an increased risk of atherosclerosis in FMF patients.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever

et al. 2015

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“…C-Reactive Protein (CRP) is a member of Pentraxin family, which plays a key role in the innate immune response. CRP is the most sensitive acute reactant protein and its concentration increases rapidly during inflammatory processes (6)(7)(8). This protein has been shown to have prognostic value in patients with acute coronary syndromes and plays different roles in pathogenesis of atherosclerosis (7).…”

Section: Introductionmentioning

confidence: 99%

The Association between PAI-1 Gene Promoter Polymorphism and Serum Serpin E1, MDA, and Hs-CRP Levels in Coronary Artery Disease

Karimian

Farajnia

Ghojazadeh

et al. 2016

Int Cardiovasc Res J

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A B S T R A C TBackground: Coronary artery disease (CAD) caused by atherosclerosis. Studies have shown that there are a number of factors which are closely related to the development and progression of CAD that include Cellular binding molecules like Plasminogen Activator Inhibitor-1(PAI-1), Lipid peroxidation, inflammation and hemostasis. Objectives: The present case-control study aimed to evaluate the association between Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G polymorphism and oxidative stress markers and Coronary Artery Disease (CAD). Patients and Methods: Blood was drawn and DNA was extracted from 90 subjects (46 patients with angiographically diagnosed CAD and 44 age-and sex-matched healthy controls). The 4G/5G polymorphism of PAI-1 was detected by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) analysis. Besides, the risk factors, serpin E1, Malondialdehyde (MDA), high-sensitivity C-Reactive Protein (hs-CRP), and lipid profile serum levels were measured by standard methods and were compared between the two study groups using independent samples t-test, one-way ANOVA, and Mann-Whitney U test as appropriated. Results: Results: The frequency of 4G/4G genotype of PAI-1 gene was higher in the CAD patients than in the controls (28/46 (60.87%) vs. 8/44 (18.18%), P < 0.01). Additionally, the serpin E1 plasma level was significantly higher in the CAD group carrying the 4G allele compared to those homozygous for the 5G allele (P = 0.016). Besides, a significant difference was found between the 4G/4G and 5G/5G subjects of the CAD group regarding plasma High-Density Lipoprotein (HDL) (P < 0.01). Also, significant differences were observed among the three genotypes of both groups concerning the plasma levels of cholesterol, triglyceride, and Low-Density Lipoprotein (LDL). However, no significant correlation was found between PAI-1 gene polymorphism and MDA serum level, hs-CRP, and risk of CAD. Conclusion: The findings of this study suggested that 4G/4G PAI-1 polymorphism was associated with cholesterol, triglyceride, LDL, and HDL levels and could be regarded as a biomarker for risk of CAD. Our findings suggested that the 4G/5G polymorphism of the PAI-1 gene seems to be a useful marker of fibrinolytic activity. Besides, this polymorphism might contribute to defective fibrinolytic activity due to elevated PAI-1 plasma level, eventually increasing the risk of coronary artery disease. Moreover, the study results demonstrated that this genetic variation might be important in correlation with some other factors, such as increased or decreased triglyceride, cholesterol, and LDL and HDL levels. However, no significant correlation was observed between PAI-1 4G/5G gene polymorphism and serum levels of stress oxidative factors, such as MDA and hs-CRP.

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Evaluation of the mean platelet volume in secondary amyloidosis due to familial Mediterranean fever

et al. 2013

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Familial Mediterranean fever (FMF) is an inflammatory disorder that is leading cause of secondary amyloidosis (AA). This study was designed to investigate the level of mean platelet volume (MPV) in AA. Seventy-four FMF, 29 AA patients and 180 healthy controls, were included. There was no significant difference between the cases in terms of sex and age. MPV levels were measured in all groups. In the FMF group, MPV level was significantly higher when compared to the control group. MPV level was significantly lower in AA group in comparison with the FMF and healthy control groups. In summary, our present study showed low MPV values in AA due to FMF.

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Relationship of paraoxonase-1, malondialdehyde and mean platelet volume with markers of atherosclerosis in familial Mediterranean fever: an observational study

Abstract: Our results show that PON-1 activity is lower in patients with FMF. Reduced PON-1 activity and increased MPV, independent of the oxidative stress status of these patients, may lead to increased atherosclerotic propensity in FMF.

Cited by 11 publications

References 39 publications

Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever

Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever

The Association between PAI-1 Gene Promoter Polymorphism and Serum Serpin E1, MDA, and Hs-CRP Levels in Coronary Artery Disease

Evaluation of the mean platelet volume in secondary amyloidosis due to familial Mediterranean fever

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