Evaluation of the mean platelet volume in secondary amyloidosis due to familial Mediterranean fever

Ozkayar, Nihal; Piskinpasa, Serhan; Akyel, Fatma; Dede, Fatih; Yıldırım, Tolga; Turgut, Didem; Koc, Eyup; Haznedaroğlu, İbrahim C.

doi:10.1007/s00296-013-2775-3

Cited by 8 publications

(12 citation statements)

References 33 publications

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“…In this study, we found that MPV values were similar to controls in patients who had amyloidosis with or without FMF, which is contrary to the findings of previous studies [19,20]. Although a few studies determined similar and even lower MPV levels in patients with FMF [21], most of the studies reported high MPV levels in FMF patients compared to controls [19,22].…”

Section: Discussioncontrasting

confidence: 99%

“…In 2015, Uluca et al found that the MPV values of children with FMF were significantly higher compared to healthy controls (7.8±1.1 vs. 7.3±1.4 fL) [24]. Similarly, Ozkayar et al reported that FMF patients without AA had significantly higher MPV level compared to the control group [19]. In 2015, Marzouk and colleagues found that 84% of the patients with FMF had high MPV levels and they proposed that MPV values may be used as useful markers of subclinical activity in Egyptian children with FMF [17].…”

Section: Discussionmentioning

confidence: 99%

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Assessment of Mean Platelet Volume in Patients with AA Amyloidosis and AA Amyloidosis Secondary to Familial Mediterranean Fever: A Retrospective Chart – Review Study

et al. 2019

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Background Amyloidosis is a protein-misfolding disease characterized by the deposition of aggregated proteins in the form of abnormal fibrils that disrupt tissue structure, ultimately causing disease. Amyloidosis is very frequent in untreated familial Mediterranean fever (FMF) patients and it is the most important feature that determines the prognosis of FMF disease. The mean platelet volume (MPV) in FMF has been previously studied. However, whether MPV level in FMF patients is lower or higher compared to healthy controls remains a topic of ongoing debate. In this study, we aimed to investigate MPV values and to assess the correlation between MPV and proteinuria in patients with AA amyloidosis and AA amyloidosis secondary to familial Mediterranean fever (AA-FMF) through a retrospective chart-review. Material/Methods This study was carried out on 27 patients with AA amyloidosis, 36 patients with AA amyloidosis secondary to FMF (a total of 63 patients with AA), and 29 healthy controls. There was no statistically significant difference between the AA patients and the control group (p=0.06) or between the AA-FMF group and the control group in terms of MPV values (p=0.12). Results We found a statistically significant negative correlation between MPV and thrombocyte count in all groups (p<0.05 for all groups), but there was no correlation between MPV and proteinuria levels in AA patients (p=0.091). Conclusions While similar results also exist, these findings are contrary to the majority of previous studies. Therefore, further controlled clinical prospective trials are necessary to address this inconsistency.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Assessment of Mean Platelet Volume in Patients with AA Amyloidosis and AA Amyloidosis Secondary to Familial Mediterranean Fever: A Retrospective Chart – Review Study

et al. 2019

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“…MPV was significantly lower in FMF patients with amyloidosis than in patients without amyloidosis and in control subjects. In addition, FMF patients without amyloidosis had higher MPV values than healthy controls in the same study [16]. However, the results of these studies are controversial in terms of relation of MPV and FMF.…”

Section: Discussionmentioning

confidence: 97%

Usefulness of Mean Platelet Volume and Neutrophil-to-Lymphocyte Ratio for Evaluation of Children with Familial Mediterranean Fever

et al. 2014

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BackgroundFamilial Mediterranean fever (FMF) is an autoinflammatory disease characterized by recurrent attacks of serositis, fever, and rash. Clinical and subclinical inflammatory processes may contribute to atherosclerosis in FMF patients, with mean platelet volume (MPV) as a potential indicator for atherosclerosis risk and neutrophil-to-lymphocyte ratio (NLR) as a marker for subclinical inflammation in these patients. In this study, we investigated whether MPV can be used as an indicator for atherosclerosis risk and if NLR is a marker for subclinical inflammation in FMF patients.Material/MethodsThe study consisted of 75 FMF patients in attack, 157 attack-free patients, and 77 healthy controls. White blood cell count neutrophil-to-lymphocyte ratio, platelet count, MPV, PDW C-reactive protein levels, and erythrocyte sedimentation rate were recorded.ResultsThere were no significant differences between attack, attack-free, and control groups in terms of mean MPV and PDW value. NLR value was higher in the attack group. NLR value was similar in attack-free and control groups.ConclusionsWe found that MPV and PDW values are similar in FMF patients and healthy controls. NLR was higher in FMF patients in the attack period. Therefore, our results suggest that MPV and PDW values do not predict atherosclerosis risk in pediatric FMF patients, and NLR may be an indicator for attack period but not attack-free period.

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“…Similar to the present study, the authors determined a negative correlation between disease severity score and MPV in FMF patients who did not have attacks. In another study, Ozkayar et al compared 74 FMF patients without amyloidosis and 29 FMF patients with amyloidosis with 180 healthy controls (15). The authors found significantly higher MPV levels in FMF patients without amyloidosis compared to the controls, but lower MPV levels in FMF patients with amyloidosis compared to FMF patients without amyloidosis and controls.…”

mentioning

confidence: 99%

Can Mean Platelet Volume be a Surrogate Marker of Inflammation in Rheumatic Diseases?

et al. 2015

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Evaluation of the mean platelet volume in secondary amyloidosis due to familial Mediterranean fever

Cited by 8 publications

References 33 publications

Assessment of Mean Platelet Volume in Patients with AA Amyloidosis and AA Amyloidosis Secondary to Familial Mediterranean Fever: A Retrospective Chart – Review Study

Assessment of Mean Platelet Volume in Patients with AA Amyloidosis and AA Amyloidosis Secondary to Familial Mediterranean Fever: A Retrospective Chart – Review Study

Usefulness of Mean Platelet Volume and Neutrophil-to-Lymphocyte Ratio for Evaluation of Children with Familial Mediterranean Fever

Can Mean Platelet Volume be a Surrogate Marker of Inflammation in Rheumatic Diseases?

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