Relationship of natural killer-cell activity to rhesus antigens in man

Hersey, Peter; Edwards, Anne; Trilivas, C; Shaw, Helen M.; Milton, G. W.

doi:10.1038/bjc.1979.46

Cited by 16 publications

(8 citation statements)

References 13 publications

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“…The series of the investigations regarding the relationship between blood type and biological phenomena of human tumors demonstrated that blood type or blood group antigen must have some biological significance associated with an immunological aspect. 17 The prominent findings in the current study were a significant correlation of blood group O with a lower incidence of poorly differentiated squamous cell carcinoma, a significantly higher proportion of far advanced carcinoma in patients with blood group AB, and, in contrast, a lack of an association between ABO blood group and prognosis in patients with esophageal SCCs. Slater et al reported that all of the multiple cancers of colon and rectum were found in patients with Rh+ blood type.…”

Section: Discussionmentioning

confidence: 38%

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Correlation of ABO blood group with clinicopathologic characteristics of patients with esophageal squamous cell carcinoma

Nozoe

Ezaki

Baba

et al. 2004

Diseases of the Esophagus

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The aim of the current study was to determine the nvolvement of ABO blood group in clinicopathologic features in squamous cell carcinoma (SCC) of the esophagus, that has not previously been studied fully. Two hundred and eighty four consecutive patients with esophageal SCC were enrolled for the study. The relationship between patients' ABO blood group and the clinicopathologic features was analyzed. The proportion of poorly differentiated SCC among patients with blood group O was significantly lower than in those patients with other blood types (P = 0.001). The mean size of the tumors in patients with blood group AB was significantly larger than those in patients with other blood groups. The proportion of tumors associated with venous invasion was significantly higher in patients with blood type A than those of tumors in other blood types (P = 0.007). The TNM stages of tumors in blood group AB were found to be significantly more advanced (P = 0.036) than other groups. The functional significance of ABO blood group distribution might be associated with biological behavior of SCCs. However, it was found not to be a clinical predictor for the prognosis of the patients with esophageal SCC.

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Section: Discussionmentioning

confidence: 38%

Section: Discussionmentioning

confidence: 99%

Correlation of ABO blood group with clinicopathologic characteristics of patients with esophageal squamous cell carcinoma

Nozoe

Ezaki

Baba

et al. 2004

Diseases of the Esophagus

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“…Another genetic marker which we have recently shown may be associated with NK activity is the Rhesus antigen system, in that Rh-subjects appeared to have higher NK activity than Rh+ subjects (Hersey et al, 1979b). Examination of patients and relatives in this study revealed a low incidence of Rh-subjects.…”

Section: Discussionmentioning

confidence: 48%

“…The mean NK value of 80 normal subjects was 14-97±5-78 for the MM200 target cell (Hersey et al, 1978) and 14-68±6'2 against the Chang target cell (Hersey et al, 1979b). [This latter value was higher than the mean value of 9.6% recorded in Hersey et al (1978).…”

Section: Reproducibility Of the Assaysmentioning

confidence: 82%

Low natural-killer-cell activity in familial melanoma patients and their relatives

Hersey¹,

Edwards²,

Honeyman³

et al. 1979

Br J Cancer

Self Cite

133

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Summary.-Patients with melanoma who had one or more close relatives with melanoma were studied for their natural-killer-cell (NK) activity against cultured melanoma cells and Chang cells. A high proportion of the patients and their relatives were found to have low NK activity against these target cells. In most of the patients this could not be attributed to general depression of their immune function, since Band T-cell numbers and the mitogenic response to PHA were within normal limits. The levels of NK activity of the patients and their relatives were found to be significantly correlated, suggesting that the NK activity in these families may have been genetically (or environmentally) determined. Several genetic markers were examined in the patients and their relatives for association with the disease state and NK activity. No association with HLA antigens or ABO blood groups was detected, but there was a low incidence of the Rhesus negative phenotype in the patients (the Rh phenotype had previously been associated with high NK activity).The present results indicate that NK activity has a familial association in families with a high incidence of melanoma, and raise the question whether low NK activity may be one of the predisposing factors in the development of familial melanoma.

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“…These have been reported for both ABO and Rhesus systems, involving differences in susceptibility to certain bacterial infections and autoimmune disease in the ABO groups [7] and higher natural killer (NK) cell activity [6,10] but increased susceptibility to virus infections [7] in Rh (D)-negative individuals. Natural antibody activity and lymphocyte responses to mito-0340-7004/81/0011/0287/$ 01.00…”

Section: Summary After Resection Lung Cancer Patients Treated With mentioning

confidence: 99%

Blood groups and the response to immunotherapy

Anthony

1981

Cancer Immunol Immunother

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Summary. After resection, lung cancer patients treated with levamisole who were blood group 0 and~or Rhesus (D)-negative showed poorer survival than all other patients, both in the post-operative period and in later follow-up. Palliative Rh-negative patients showed a similar effect. Differential response to immunotherapy by blood group could have implications for the interpretation of immunotherapy trials.We have reported that excess post-operative deaths in levamisole-treated lung cancer patients were more frequent in patients who were blood group 0 and/or Rh (D)-negative [3]. The excess deaths were due to cardiorespiratory failure and were associated (in the only cases where serum samples were available for testing) with the presence of antimyocardial antibodies that were not detected in any patient without the syndrome. Autoimmune disease is more common in group 0 individuals [7]; it was concluded that pre-treatment with levamisole before handling of the heart and great vessels had induced cardiac autoimmunity with unwontedly serious effects because of the alterations in the pulmonary vascular bed resulting from lung resection.It now appears that the poorer survival of group 0 and Rh-negative patients receiving levamisole was not limited to the post-operatiw~ period. The survival of all resected patients (217) by ABO blood group (0 and not 0) and by Rhesus blood group, with levamisole or placebo therapy is shown on Fig. 1. Patients who had blood group 0 or were Rh-negative showed significantly poorer survival if treated with levamisole. The difference was unaffected by controlling for the extent of disease at operation (Table 1), and was still present when the patients who died in the 6 weeks after operation were excluded by starting the analysis at the seventh week (Table 1). The effects of the two blood group factors were largely independent, only three levamisole-treated patients being both group 0 and Rh-negative.Recurrent tumour had been detected or suspected in most of the patients who died after the post-operative period, but there were five unexpected deaths among levamisole-treated patients, all cardiac in type. Four of these patients were group 0, Rh-positive and the fifth group A, Rh-negative.Ninety-eight other patients had palliative or exploratory operations only. Among these, levamisole-treated Rh-negative patients showed poorer survival than placebo-treated and Rh-positive patients (O/E 2.3 Z 2 7.4 P < 0.02). However, the survival of levamisole-treated group 0 patients did not differ from that of the rest of the palliative group.Harris et al. [5] have recently reported that genetic factors influenced the response of patients with acute myeloid leukaemia (AML) to immunotherapy with BCG and allogeneic cells after cytoreduction. Immunotherapy preferentially improved the length of first remission and the length of survival of patients who were blood group A, Rh (D)-positive or HLA B12 compared, in each case, with all the rest of the patients.In each of these studies immunotherapy showed interaction...

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Relationship of natural killer-cell activity to rhesus antigens in man

Cited by 16 publications

References 13 publications

Correlation of ABO blood group with clinicopathologic characteristics of patients with esophageal squamous cell carcinoma

Correlation of ABO blood group with clinicopathologic characteristics of patients with esophageal squamous cell carcinoma

Low natural-killer-cell activity in familial melanoma patients and their relatives

Blood groups and the response to immunotherapy

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