Correlation of ABO blood group with clinicopathologic characteristics of patients with esophageal squamous cell carcinoma

Abstract

The aim of the current study was to determine the nvolvement of ABO blood group in clinicopathologic features in squamous cell carcinoma (SCC) of the esophagus, that has not previously been studied fully. Two hundred and eighty four consecutive patients with esophageal SCC were enrolled for the study. The relationship between patients' ABO blood group and the clinicopathologic features was analyzed. The proportion of poorly differentiated SCC among patients with blood group O was significantly lower than in those patients with other blood types (P = 0.001). The mean size of the tumors in patients with blood group AB was significantly larger than those in patients with other blood groups. The proportion of tumors associated with venous invasion was significantly higher in patients with blood type A than those of tumors in other blood types (P = 0.007). The TNM stages of tumors in blood group AB were found to be significantly more advanced (P = 0.036) than other groups. The functional significance of ABO blood group distribution might be associated with biological behavior of SCCs. However, it was found not to be a clinical predictor for the prognosis of the patients with esophageal SCC.

Relative Risk of Various Head and Neck Cancers Among Different Blood Groups: An Analytical Study

“…Esophageal cancer was also found more in patients of A blood Group which is similar to a study done by Guleria et al, 2005, Pinkston JA et al, Nozoe T et al, [21][22][23] whereas contradictory results were found by Aminien A et al, [24] which shows the…”

Relationships between Skin Cancers and Blood Groups - Link between Non-melanomas and ABO/Rh Factors

“…Several studies investigated a possible association of the blood groups and its frequency with clinicopathological parameters and prognosis of the diseases in patients with esophageal, cardiac, gastric, pulmonary, hypopharyngeal, salivary gland, gynecological, colorectal, pancreatic, bone, bladder, urethral, and renal cancer (Mittal, 1970;Slater et al, 1993;Pinkston and Cole, 1996;Su et al, 2001;Nozoe et al, 2004;Adamian, 2005;Mehrazin, 2006;El Hajj et al, 2007). Jordon et al reported that blood group antigens might be useful in the differential diagnosis of malignant pleural mesothelioma (MPM) and adenocarcinoma (Jordon et al, 1989).…”

Genetic Analysis of ABO and Rh Blood Groups in Backward Caste Population of Uttar Pradesh, India

“…The ABO blood group has been reported to be associated with many diseases likecancer (Dabelsteen and Gao, 2005;Guleri et al, 2005;Iodice et al, 2010;Nozoe et al, 2004;Sharma et al, 2007;Vadivelu et al, 2004;Xie et al, 2010), eye diseases (Dhillon and Shergill, 2004;Khan et al, 2009;Mourant et al, 1976;Zaree et al, 2006), skin diseases (Gangopadhyay et al, 2006;Valikhani et al, 2007), cardiovascular diseases (Biswas et al, 2008;Skaik, 2009), diabetes (Koley, 2008Okon et al, 2008), malaria (Deepa et al, 2011;Jeremiaha et al, 2010), infectious diseases like-Smallpox (Krieger and Vilente, 1969), Leprosy and cholera (Urade and Chakravarty, 1999) and Cholera (Harris et al, 2005) though the explanation for the association between ABO blood groups and disease is still unclear. In addition information of blood groups is very useful in blood transfusion and organ transplantation medicine, in human population migration and evolution study, in genetic research and in parental dispute cases.It is, therefore, imperative to have information on the distribution of these blood groups in any population group.…”