Relationship of MTHFR and ACE gene Variations with Migraine Susceptibility: A Case-Control Study in the Population of North India (Jammu)

Jasrotia, Raman; Raina, Jyotdeep Kour; Sharma, Minakshee; Panjaliya, Rakesh Kumar; Kundal, B.R.; Kumar, Parvinder

doi:10.13005/bbra/2694

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…Therefore, the current study aimed to find out the prevalence of the headache condition and its two major types, including migraine and TTH, in the region of the Jammu Division of the north Indian population. To the best of our knowledge, this is the first study of its kind on neuroepidemiology to discuss headache and its types other than the case-control design ( 12 ) in the present region utilizing the cross-sectional study design; hence, this insight shall provide the foundation for future research.…”

Section: Introductionmentioning

confidence: 98%

Neuroepidemiology study of headache in the region of Jammu of north Indian population: A cross-sectional study

Sudershan

Pushap²,

Younis³

et al. 2023

Front. Neurol.

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BackgroundHeadache disorders now represent a major public health problem globally. It is more prevalent in developing countries with the rising trends of headache disorders observed in young adults affecting their quality of life negatively. Very little information is available on the epidemiology of headache disorders in the Jammu Division of the north Indian population.AimThe aim of the present study was to find out the prevalence of headache and its two major types, i.e., migraine and tension-type headache (TTH), in the population of the Jammu Division.MethodsThe present study was conducted in two phases: (Phase I: face-to-face interview and Phase II: E-based sampling) and the sufferers of headaches were incorporated into the study based on the International Classification of Headache Disorder-3 (ICHD-3) criteria for a representative sample. Frequency distribution and mean ± standard deviation were used in descriptive statistics to describe the data sets, while a t-test, chi-square test, multiple logistic regression, and prevalence ratio were used in inferential statistics.ResultsIn the present study, a total of 3,148 patients were recruited, with an overall prevalence of headache of 53.84%, with a majority of females (38.18%) over males (15.66%). As regards the type of headache, migraine was found to be of the more prevalent (33.25%) type than the TTH (20.58%). Females suffering from migraine showed the highest prevalence (25.28%), in contrast to females suffering from the TTH (12.89%). Sociodemographic variables, such as gender [female; AOR = 2.46, 95% CI (2.12–2.85), p-value < 0.0001] and marital status [married; AOR: 1.46, 95% CI (1.11–1.92) p-value = 0.006], showed a significant association with the headache.ConclusionThe present study shows that the prevalence of headache is high in the Jammu Division of Jammu and Kashmir (J&K) India, with migraine being the highly prevalent type.

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Section: Introductionmentioning

confidence: 98%

Neuroepidemiology study of headache in the region of Jammu of north Indian population: A cross-sectional study

Sudershan

Pushap²,

Younis³

et al. 2023

Front. Neurol.

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A Comprehensive Investigation into the Association Between Mthfr C677t, A1298c, and Ace I/D Variants and Risk of Migraine: an Updated Meta-Analysis of Genetic Association Studies with Trial Sequential Analysis and Meta-Regression

Sudershan,

Pushap,

Kumar

et al. 2023

J Mol Neurosci

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Comprehensive analysis of genes associated with migraine in the Indian population: a meta-analysis of genetic association studies with trial sequential analysis

Sudershan,

Pushap,

Bhagat

et al. 2023

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Migraine is a complex disorder with multigenic inheritance and is characterized by the cardinal symptom of unilateral headache. Many genes are responsible for increasing the susceptibility of disease within different populations. Therefore, our primary aim in this review was to catalog the many genes that have been studied in India and after collecting the necessary information, we calculated a more precise risk relationship between an identified variation and migraine. The gene and its associated risk variant were discovered in the Indian population using a PRISMA-based systematic literature review guideline from online databases such as PubMed & Google Scholar. We constructed pooled odds ratios with 95% confidence intervals using multiple genetic models. Also, we looked for heterogeneity using Cochran's Q Test and the I2 statistic. Publication bias was analyzed using Begg's and Egger's tests. A p-value less than 0.05 was judged to be statistically significant for all tests. After a critical analysis, a total of 24 studies explored about 21 genes with 31 variants out of which only nine genes have been studied more than two times in the Indian population and thus were found eligible for the meta-analysis. It has been found, that the ACE-DD variant (allele model: OR: 1.37 [1.11–1.69], I2 = 0%/ fixed model), ESR1-PvuII (allele model: OR: 1.47 [1.24–1.74], I2 = 0%/ fixed model) significantly increases the risk of migraine in Indian population. Also, a protective role of the LRP1-rs11172113variant was observed for both migraine and its clinical subtype i.e., MA (allelic model: OR of 0.65 [0.50–0.83] I2 = 44% and allele: OR: 0.54 [0.37–0.78], I2 = 52%) respectively. Overall, the results of this meta-analysis indicated that the ACE-DD variant and the ESR1-PvuII were associated with an increased risk of migraine in the Indian community, while the LRP1-rs11172113 variant was associated with protection from migraine in this population.

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Relationship of MTHFR and ACE gene Variations with Migraine Susceptibility: A Case-Control Study in the Population of North India (Jammu)

Cited by 3 publications

References 39 publications

Neuroepidemiology study of headache in the region of Jammu of north Indian population: A cross-sectional study

Neuroepidemiology study of headache in the region of Jammu of north Indian population: A cross-sectional study

A Comprehensive Investigation into the Association Between Mthfr C677t, A1298c, and Ace I/D Variants and Risk of Migraine: an Updated Meta-Analysis of Genetic Association Studies with Trial Sequential Analysis and Meta-Regression

Comprehensive analysis of genes associated with migraine in the Indian population: a meta-analysis of genetic association studies with trial sequential analysis

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