Relationship of long-term air pollution exposure with asthma and rhinitis in Italy: an innovative multipollutant approach

Maio, Sara; Fasola, Salvatore; Marcon, Alessandro; Angino, Anna; Baldacci, Sandra; Bilò, Maria Beatrice; Bono, Roberto; Grutta, Stefania La; Marchetti, Pierpaolo; Sarno, Giuseppe; Squillacioti, Giulia; Stanisci, Ilaria; Pirina, Pietro; Tagliaferro, Sofia; Verlato, Giuseppe; Villani, Simona; Gariazzo, Claudio; Stafoggia, Massimo; Viegi, Giovanni

doi:10.1016/j.envres.2023.115455

Cited by 17 publications

(6 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the first step, Principal Component Analysis (PCA) was performed separately in each a priori defined exposure domain. This methodology has been widely used in recent literature (35)(36)(37) and allows to synthesize the multiple variables of the domain into a reduced set of independent principal components (PCs), e.g., linear combinations of the original variables. Such PCs were arranged in descending order of variance and were mutually orthogonal.…”

Section: Discussionmentioning

confidence: 99%

External exposome and all-cause mortality in European cohorts: the EXPANSE project

Nobile,

Dimakopoulou,

Åström

et al. 2024

Front. Epidemiol.

Self Cite

View full text Add to dashboard Cite

BackgroundMany studies reported associations between long-term exposure to environmental factors and mortality; however, little is known on the combined effects of these factors and health. We aimed to evaluate the association between external exposome and all-cause mortality in large administrative and traditional adult cohorts in Europe.MethodsData from six administrative cohorts (Catalonia, Greece, Rome, Sweden, Switzerland and the Netherlands, totaling 27,913,545 subjects) and three traditional adult cohorts (CEANS-Sweden, EPIC-NL-the Netherlands, KORA–Germany, totaling 57,653 participants) were included. Multiple exposures were assigned at the residential addresses, and were divided into three a priori defined domains: (1) air pollution [fine particulate matter (PM2.5), nitrogen dioxide (NO₂), black carbon (BC) and warm-season Ozone (warm-O3)]; (2) land/built environment (Normalized Difference Vegetation Index—NDVI, impervious surfaces, and distance to water); (3) air temperature (cold- and warm-season mean and standard deviation). Each domain was synthesized through Principal Component Analysis (PCA), with the aim of explaining at least 80% of its variability. Cox proportional-hazards regression models were applied and the total risk of the external exposome was estimated through the Cumulative Risk Index (CRI). The estimates were adjusted for individual- and area-level covariates.ResultsMore than 205 million person-years at risk and more than 3.2 million deaths were analyzed. In single-component models, IQR increases of the first principal component of the air pollution domain were associated with higher mortality [HRs ranging from 1.011 (95% CI: 1.005–1.018) for the Rome cohort to 1.076 (1.071–1.081) for the Swedish cohort]. In contrast, lower levels of the first principal component of the land/built environment domain, pointing to reduced vegetation and higher percentage of impervious surfaces, were associated with higher risks. Finally, the CRI of external exposome increased mortality for almost all cohorts. The associations found in the traditional adult cohorts were generally consistent with the results from the administrative ones, albeit without reaching statistical significance.DiscussionVarious components of the external exposome, analyzed individually or in combination, were associated with increased mortality across European cohorts. This sets the stage for future research on the connections between various exposure patterns and human health, aiding in the planning of healthier cities.

show abstract

Section: Discussionmentioning

confidence: 99%

External exposome and all-cause mortality in European cohorts: the EXPANSE project

Nobile,

Dimakopoulou,

Åström

et al. 2024

Front. Epidemiol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…A comprehensive investigation into the prolonged exposure to outdoor air pollution and its correlation with symptom prevalence and respiratory/allergic diseases unveiled significant associations. Specifically, PM 10 and PM 2.5 exhibited a 14%–25% increase in rhinitis prevalence, while NO 2 showed a 6%–9% probability increase in rhinitis occurrence ( 32 ).…”

Section: Outdoor Pollutionmentioning

confidence: 99%

Air pollution and rhinitis

Rosario,

Urrutia-Pereira,

Murrieta-Aguttes

et al. 2024

Front. Allergy

View full text Add to dashboard Cite

Rhinitis arises from either allergic or non-allergic inflammation of the nasal mucosa, characterized by the infiltration of inflammatory cells into the tissue and nasal secretions, along with structural alterations in the nasal mucosa. The pathways through which air pollution affects rhinitis may diverge from those affecting asthma. This article aims to review the effects of diverse air pollutants on the nose, the correlation of climate change and pollution, and how they aggravate the symptoms of patients with rhinitis.

show abstract

“…In particular, microRNA networks and genes are related to asthma severity, such as hsa-miR-223-3p, a neutrophil-derived microRNA, which plays a key role in TLR/Th17 signalling and endoplasmic reticulum stress [ 49 ]. Taking these data into account, deregulation of miR-223-3p following PM2.5 and ozone highlights the role of air pollutants in the development of many diseases other than cancer [ 50 ].…”

Section: Mirna Air Pollutants and Airways Diseasesmentioning

confidence: 99%

Air Pollution and microRNAs: The Role of Association in Airway Inflammation

Furci

Allegra

Tonacci

et al. 2023

Life

View full text Add to dashboard Cite

Air pollution exposure plays a key role in the alteration of gene expression profiles, which can be regulated by microRNAs, inducing the development of various diseases. Moreover, there is also evidence of sensitivity of miRNAs to environmental factors, including tobacco smoke. Various diseases are related to specific microRNA signatures, suggesting their potential role in pathophysiological processes; considering their association with environmental pollutants, they could become novel biomarkers of exposure. Therefore, the aim of the present work is to analyse data reported in the literature on the role of environmental stressors on microRNA alterations and, in particular, to identify specific alterations that might be related to the development of airway diseases so as to propose future preventive, diagnostic, and therapeutic strategies.

show abstract

Relationship of long-term air pollution exposure with asthma and rhinitis in Italy: an innovative multipollutant approach

Cited by 17 publications

References 47 publications

External exposome and all-cause mortality in European cohorts: the EXPANSE project

External exposome and all-cause mortality in European cohorts: the EXPANSE project

Air pollution and rhinitis

Air Pollution and microRNAs: The Role of Association in Airway Inflammation

Contact Info

Product

Resources

About