Air Pollution and microRNAs: The Role of Association in Airway Inflammation

Furci, Fabiana; Allegra, Alessandro; Tonacci, Alessandro; Isola, S.; Senna, Gianenrico; Pioggia, Giovanni; Gangemi, Sebastiano

doi:10.3390/life13061375

Cited by 2 publications

(1 citation statement)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, considering the existence of a bidirectional relationship between miRNAs, a novel group of small endogenous non-coding miRNA molecules that are involved in gene expression through base complementarity between the seed region of the miRNA and the 3 -untranslated region (UTR) of the target mRNA, and microbiota, it is more and more evident how miRNA modulation might become a significant therapeutic opportunity for the treatment of many diseases [96,97].…”

Section: Possible Therapeutic Strategies For the Recovery Of Microbio...mentioning

confidence: 99%

Microbiota, Diet and Acute Leukaemia: Tips and Tricks on Their Possible Connections

Furci,

Cicero,

Allegra

et al. 2023

Nutrients

Self Cite

View full text Add to dashboard Cite

Acute leukaemia is probably one of the most recurrent cancers in children and younger adults, with an incidence of acute lymphoblastic leukaemia in 80% of cases and an incidence of acute myeloid leukaemia in 15% of cases. Yet, while incidence is common in children and adolescents, acute leukaemia is a rare disease whose aetiology still requires further analysis. Many studies have investigated the aetiology of acute leukaemia, reporting that the formation of gut microbiota may be modified by the start and development of many diseases. Considering that in patients affected by acute lymphoblastic leukaemia, there is an inherent disequilibrium in the gut microbiota before treatment compared with healthy patients, increasing evidence shows how dysbiosis of the gut microbiota provokes an inflammatory immune response, contributing to the development of cancer. Our analysis suggeststhe key role of gut microbiota in the modulation of the efficacy of leukaemia treatment as well as in the progress of many cancers, such as acute leukaemia. Therefore, in this paper, we present an examination of information found in literature regarding the role of dietary factors and gut microbiota alterations in the development of leukaemia and suggest possible future preventive and therapeutic strategies.

show abstract

Section: Possible Therapeutic Strategies For the Recovery Of Microbio...mentioning

confidence: 99%

Microbiota, Diet and Acute Leukaemia: Tips and Tricks on Their Possible Connections

Furci,

Cicero,

Allegra

et al. 2023

Nutrients

Self Cite

View full text Add to dashboard Cite

show abstract

Pollutants, microbiota and immune system: frenemies within the gut

Rio,

Gasbarrini,

Gambassi

et al. 2024

Front. Public Health

View full text Add to dashboard Cite

Pollution is a critical concern of modern society for its heterogeneous effects on human health, despite a widespread lack of awareness. Environmental pollutants promote several pathologies through different molecular mechanisms. Pollutants can affect the immune system and related pathways, perturbing its regulation and triggering pro-inflammatory responses. The exposure to several pollutants also leads to alterations in gut microbiota with a decreasing abundance of beneficial microbes, such as short-chain fatty acid-producing bacteria, and an overgrowth of pro-inflammatory species. The subsequent intestinal barrier dysfunction, together with oxidative stress and increased inflammatory responses, plays a role in the pathogenesis of gastrointestinal inflammatory diseases. Moreover, pollutants encourage the inflammation-dysplasia-carcinoma sequence through various mechanisms, such as oxidative stress, dysregulation of cellular signalling pathways, cell cycle impairment and genomic instability. In this narrative review, we will describe the interplay between pollutants, gut microbiota, and the immune system, focusing on their relationship with inflammatory bowel diseases and colorectal cancer. Understanding the biological mechanisms underlying the health-to-disease transition may allow the design of public health policies aimed at reducing the burden of disease related to pollutants.

show abstract

Air Pollution and microRNAs: The Role of Association in Airway Inflammation

Cited by 2 publications

References 87 publications

Microbiota, Diet and Acute Leukaemia: Tips and Tricks on Their Possible Connections

Microbiota, Diet and Acute Leukaemia: Tips and Tricks on Their Possible Connections

Pollutants, microbiota and immune system: frenemies within the gut

Contact Info

Product

Resources

About