Relationship of Leukocyte Groups to Tissue Transplantation Compatibility

Serotyping for Homotransplantation IV Grouping and Evaluation of Lymphotoxic Sera*

“…I n addition to underlying compatibility, use of multispecific sera would be expected t o mask incompatibilities for the reactions of 2 cells of different specificities reacting with 2 different component antibodies in a serum will be misinterpreted to mean that the cells are compatible. This difficulty in use of unabsorbed serum was encountered by VAN ROOD et al [26] who found that 3 pairs of individuals whose leukocytes were shown t o be compatible with 60 antisera by leukoagglutination, promptly rejected skin transplants. Similarly, COLOMBANI and DAUSSET [6] attributed much of the difficulty in predicting skin homograft survival to the fallacious degree of compatibility indicated b y multiparous sera.…”

Leucocyte Groups and Histocompatibility

“…Indirect evidence that leucocyte antigens and transplantation antigens are related is given by observations such as: The formation of group-specific leucocyte antibodies after the rejection of a graft [ l l , 35,38,471 The wide distribution of leucocyte antigens in cells and tissues other than the leucocyte [18, 361 The finding that the same fraction of the leucocyte, i.e. the microsomal fraction containing the transplantation antigens [32], also contains the leucocyte antigens [5, 61 The immunogenetic evidence that the transplantation antigens follow the same genetic rules as the leucocyte groups [42] The correlation between the outcome of the normal lymphocyte transfer test (NLT) with the degree of compatibility between donor arid recipient as regards their leucocyte groups [LEO].…”

The long and winding road towards epitope matching in clinical transplantation

“…After the discovery that blood transfusion and pregnancy can lead to the induction of leucocyte‐reactive antibodies , it soon became clear that the antigens recognized by these antibodies played a pivotal role in the immune response leading to graft rejection after kidney transplantation. When donors and recipients had the same HLA type, graft and patient survival was significantly better than in case of HLA mismatched transplants . These first results were obtained with transplants using living related donors, often siblings of the patient, which made the chance of transplanting an HLA identical graft relatively high.…”