Relationship of high sensitivity C-reactive protein with presence and severity of coronary artery disease

Abstract

Objective: Inflammation plays a key role in the pathogenesis of atherosclerosis. This study aimed to assess the relationship of serum inflammatory marker high sensitivity C Reactive protein (hsCRP), with the presence and severity of angiographically evaluated coronary artery disease (CAD). Methods: This study was conducted at departments of physiology and cardiology, College of Medicine & King Khalid University Hospital, King Saud University, Riyadh from August 2009 to March 2012. Eighty seven patients (57 males and 30 females) with angiographically evaluated CAD were studied. In all these patients CAD severity was assessed by Gensini scoring and vessel scoring. Control group consisted of 29 healthy subjects (17 males and 12 females). Fasting venous blood samples were analyzed for lipid profile and high sensitivity C-reactive protein (hsCRP). Results: There were non-significant differences in age, weight and BMI among healthy subjects and CAD patients. Comparison of lipid profile between control and CAD patients showed that CAD patients had significantly higher TG and significantly lower HDL levels compared to control subjects. CAD patients presented with significantly higherhsCRP levels than controls. Linear regression analysis between hsCRP and CAD severity determined by Gensini scores showed a significant positive correlation (r=0.423, p=0.018). Triple vessel disease patients had significantly higher hsCRP levels than one vessel and two vessel disease, while the difference was non significant between one and two vessel disease groups. Conclusions: These results suggest that patients with angiographically evaluated CAD have significantly higher levels of hsCRP levels compared to healthy individuals and are correlated with the presence & severity of CAD.

Associations between IL-6 and Echo-Parameters in Patients with Early Onset Coronary Artery Disease

“…Unsurprisingly, we observed that IL-6 level positively correlates with other inflammatory parameters hsCRP and WBC, which is consistent with the results of other studies [19]. The levels of IL-6 [1,15,37] and hsCRP [38,39] could help predict the angiographic severity of CAD. It is well-known that these inflammatory markers have been linked to coronary events.…”

High sensitive CRP as a predictor of Coronary Artery Disease Severity on Coronary Angiography

“…In this study we revealed statistically a significant difference in the level of hsCRP between patients with normal coronary arteries compared to those having angiographically atherosclerotic coronary artery lesions. A finding that was supported by earlier studies [10]. Here we detected as well a significant difference in the level of hsCRP between patients with single, two vessels and three vessels diseases, a finding which was comparable with other studies which detected higher hsCRP among patients with more severe coronary artery lesions, [11,7].…”

Increased carotid intima-media thickness associated with high hs-CRP levels is a predictor of unstable coronary artery disease : cardiovascular topic

“…These data are also not consistent with data from other authors. Saudi patients with stable chronic CAD had higher hs-CRP levels compared to healthy individuals 27. Khan et al found that patients with chronic stable angina had elevated levels of hs-CRP 28…”