Relationship of Helicobacter pylori Infection to Arterial Stiffness in Japanese Subjects

Saijo, Yasuaki; Utsugi, Megumi; Yoshioka, Eiji; Horikawa, Naoko; Sato, Tetsuro; Gong, Yingyan; Kishi, Reiko

doi:10.1291/hypres.28.283

Cited by 30 publications

(48 citation statements)

References 35 publications

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“…Although a recent metaanalysis found no significant association between Helicobacter pylori seropositivity and coronary heart disease [36], several Japanese studies have revealed a positive association [37][38][39]. Furthermore, we have found a significant association between H. pylori seropositivity and baPWV elevation, and a combination of hs-CRP elevation and H. pylori seropositivity shows a stronger association with baPWV elevation [40]. Because Japanese have a higher prevalence of H. pylori seropositivity compared with the populations of other developed countries [41], there is a particular need for the influence of chronic H. pylori infection on atherosclerosis to be elucidated in the Japanese population.…”

Section: Inflammation and Hs-crpcontrasting

confidence: 70%

Inflammation as a cardiovascular risk factor and pulse wave velocity as a marker of early-stage atherosclerosis in the Japanese population

Saijo

Utsugi

Yoshioka

et al. 2009

Environ Health Prev Med

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Inflammation and pulse wave velocity (PWV) are a potential risk factor and marker, respectively, for atherosclerosis in the primary prevention setting. Atherosclerosis is now generally accepted to be an inflammatory disorder of the arterial wall, and the high-sensitivity Creactive protein (hs-CRP) level has been reported to be a strong predictor of cardiovascular events. High-sensitivity-CRP is associated with two factors related to inflammation: (1) the local production of CRP by atheromatous tissue or coronary artery smooth muscle cells and (2) adipose tissue as a potent source of inflammatory cytokines. Based on studies in North America and Europe, hs-CRP has been established as a cardiovascular risk factor and a cut-off value has been recommended. However, Japanese have lower hs-CRP values than their Western counterparts, partly because Japanese have a lower body mass index (BMI), which correlates positively to hs-CRP, and partly because lifestyle and genetic factors can affect hs-CRP values. Therefore, a cut-off value needs to be established by cohort studies for the Japanese population. Carotidfemoral PWV is most commonly measured by applanation tonometry, particularly in Europe, but this method is critically dependent upon the accurate placing of transducers over the arteries and is both time-consuming and complex. A novel device has been recently developed in Japan that measures brachial-ankle PWV (baPWV) using a volumerendering method. Brachian-ankle PWV is a suitable screening method because of its technical simplicity and shorter measurement time. It is associated not only with conventional cardiovascular risk factors but also with new risk factors, such as inflammation, c-glutamyltransferase, chronic kidney disease, and psychosocial factors. However, a suitable cut-off value has yet to be established.

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Section: Inflammation and Hs-crpcontrasting

confidence: 70%

Inflammation as a cardiovascular risk factor and pulse wave velocity as a marker of early-stage atherosclerosis in the Japanese population

Saijo

Utsugi

Yoshioka

et al. 2009

Environ Health Prev Med

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“…Previous reports stated that arterial stiffness evaluated by baPWV differed according to HP status in the young, but not in the elderly [19][20][21] . Adachi et al reported that in subjects under 39 years of age, baPWV was higher in the HP-positive group than in HP-negative subjects; however, the same group of investigators failed to show such a difference in subjects over 40 years of age.…”

Section: Discussionmentioning

confidence: 85%

“…While both parameters are calculated from the pulse transit time and distance traveled by pulse between two recording sites, CAVI has been shown to be less dependent on blood pressure than baPWV 18) . It has been shown that the arterial stiffness determined by baPWV was higher in HP-positive subjects than in HP-negative subjects, even though such a result has been observed only in young subjects [19][20][21] . Pepsinogens (PGs) are precursors of pepsin and consist of two isozymes, PG and PG .…”

Section: Introductionmentioning

confidence: 96%

Possible Association of Atrophic Gastritis and Arterial Stiffness in Healthy Middle-Aged Japanese

Torisu

Takata

Ansai

et al. 2009

JAT

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Aim: Helicobacter pylori (HP) has been implicated as a risk factor for cardiovascular and atherosclerotic diseases. Arterial stiffness determined by pulse wave velocity (PWV) or the cardio-ankle vascular index (CAVI) has been shown to be higher in HP-positive subjects than in HP-negative subjects; however, this result has been observed only in young subjects. The aim of the study was to investigate the possible correlation between HP infection and PWV or CAVI in middle-aged subjects.

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“…According to previous publications, H. pylori infection is linked to an increased systemic inflammatory response. H. pylori, especially CagA-positive H. pylori strains, could upregulate the levels of serum hsCRP [28][29][30]. Subjects with high CRP levels tend to have a higher risk of atherosclerosis if exposed to infectious agents [15,31,32].…”

Section: Discussionmentioning

confidence: 99%

CagA-Positive Helicobacter pylori Strains Enhanced Coronary Atherosclerosis by Increasing Serum OxLDL and HsCRP in Patients with Coronary Heart Disease

et al. 2010

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Relationship of Helicobacter pylori Infection to Arterial Stiffness in Japanese Subjects

Cited by 30 publications

References 35 publications

Inflammation as a cardiovascular risk factor and pulse wave velocity as a marker of early-stage atherosclerosis in the Japanese population

Inflammation as a cardiovascular risk factor and pulse wave velocity as a marker of early-stage atherosclerosis in the Japanese population

Possible Association of Atrophic Gastritis and Arterial Stiffness in Healthy Middle-Aged Japanese

CagA-Positive Helicobacter pylori Strains Enhanced Coronary Atherosclerosis by Increasing Serum OxLDL and HsCRP in Patients with Coronary Heart Disease

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