Relationship of electrocardiographic repolarization measures to echocardiographic left ventricular mass in men with hypertension

Porthan, Kimmo; Virolainen, Juha; Hiltunen, Timo P.; Viitasalo, Matti; Väänänen, Heikki; Dabek, Juhani; Hannila‐Handelberg, Tuula; Toivonen, Lauri; Nieminen, Markku S.; Kontula, Kimmo; Oikarinen, Lasse

doi:10.1097/hjh.0b013e328263088b

Cited by 29 publications

(24 citation statements)

References 33 publications

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“…Laboratory studies are thus needed to identify the mechanisms underlying the association between phosphorus and QT interval duration. In rats, hyperphosphatemia was associated with cardiac fibrosis and myocardial hypertrophy (32,33), and the latter may then lead to longer QT intervals (34,35). It is unlikely, however, that this mechanism explains an association identified across the whole range of phosphorus concentrations in the general population.…”

Section: Discussionmentioning

confidence: 96%

Serum 25-Hydroxyvitamin D, Calcium, Phosphorus, and Electrocardiographic QT Interval Duration: Findings from NHANES III and ARIC

Zhang

Post

Dalal

et al. 2011

The Journal of Clinical Endocrinology & Metabolism

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Section: Discussionmentioning

confidence: 96%

Serum 25-Hydroxyvitamin D, Calcium, Phosphorus, and Electrocardiographic QT Interval Duration: Findings from NHANES III and ARIC

Zhang

Post

Dalal

et al. 2011

The Journal of Clinical Endocrinology & Metabolism

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“…14 All repolarization measurements were performed by a single observer, and the intraobserver variability of the measurement techniques used has been assessed previously, 15 with the coefficient of variation ranging between 0.0% and 2.7% according to the repolarization variable. For comparison, we included QT in the analyses and used heart rate adjustment with the nomogram method (QT Nc ), as previously described.…”

Section: Electrocardiographymentioning

confidence: 99%

Predictive Value of Electrocardiographic T-Wave Morphology Parameters and T-Wave Peak to T-Wave End Interval for Sudden Cardiac Death in the General Population

Porthan

Viitasalo

Toivonen

et al. 2013

Circ: Arrhythmia and Electrophysiology

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Ventricular repolarization abnormalities increase the risk of ventricular arrhythmias, and prolongation and shortening of the electrocardiographic QT interval increase the risk of SCD. 4,5 However, the association between QT duration and SCD in the general population has been relatively weak. Recently, an association between prolongation of the T-wave peak to T-wave end interval (TPE) and SCD was found in a general population sample.6 Furthermore, computerized measures of the 3-dimensional T-wave loop, the T-wave morphology parameters, have contained prognostic value for cardiovascular morbidity and mortality in several population studies, 7−12 but their relation specifically to SCD is less clear. The aim of the present study was to test the hypothesis that TPE and T-wave morphology parameters predict SCD in the general population.© 2013 American Heart Association, Inc. Original ArticleBackground-Previous population studies have found an association between electrocardiographic T-wave morphology parameters and cardiovascular mortality, but their relationship to sudden cardiac death (SCD) is not clear. To our knowledge, there are no follow-up studies assessing the association between electrocardiographic T-wave peak to T-wave end interval (TPE) and SCD. We assessed the predictive value of electrocardiographic T-wave morphology parameters and TPE for SCD in an adult general population sample. Methods and Results-A total of 4 T-wave morphology parameters (principal component analysis ratio, T-wave morphology dispersion, total cosine R-to-T, T-wave residuum) as well as TPE were measured from digital standard 12-lead ECGs in 5618 adults (46% men; mean age 50.9±12.5 years) participating in the Finnish population-based Health 2000 Study. After a mean follow-up time of 7.7±1.4 years, 72 SCDs had occurred. In univariable analyses, all T-wave morphology parameters were associated with an increased SCD risk. In multivariable Cox models, T-wave morphology dispersion and total cosine R-to-T remained as predictors of SCD, with T-wave morphology dispersion showing the highest SCD risk (hazard ratio of 1.4 [95% confidence interval 1.1−1.7, P=0.001] per 1 SD increase in the log e T-wave morphology dispersion). In contrast, TPE was not associated with SCD in univariable or multivariable analyses. Conclusions-Electrocardiographic T-wave morphology parameters describing the 3-dimensional shape of the T-wave stratify SCD risk in the general population, but we did not find an association between TPE and SCD.

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“…Regarding the degree of LVH, a positive correlation with QTc length can be observed [38]. Not many articles investigating this correlation have been published in the literature [39,40]. In some [41] only 38 patients with essential hypertension and LVH were analyzed, and an attempt to classify them into groups with regard to LVH type was made.…”

Section: Discussionmentioning

confidence: 99%

Influence of Patern and Degree of Left Ventricular Hypertrophy on Cardiac Arrhythmias

Kunišek¹

2012

Cardiac Arrhythmias - New Considerations

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Relationship of electrocardiographic repolarization measures to echocardiographic left ventricular mass in men with hypertension

Cited by 29 publications

References 33 publications

Serum 25-Hydroxyvitamin D, Calcium, Phosphorus, and Electrocardiographic QT Interval Duration: Findings from NHANES III and ARIC

Serum 25-Hydroxyvitamin D, Calcium, Phosphorus, and Electrocardiographic QT Interval Duration: Findings from NHANES III and ARIC

Predictive Value of Electrocardiographic T-Wave Morphology Parameters and T-Wave Peak to T-Wave End Interval for Sudden Cardiac Death in the General Population

Influence of Patern and Degree of Left Ventricular Hypertrophy on Cardiac Arrhythmias

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