Relationship of dehydroepiandrosterone and cortisol in disease

Hechter, Oscar; Grossman, Aaron; Chatterton, Robert T.

doi:10.1016/s0306-9877(97)90258-9

Cited by 89 publications

(47 citation statements)

References 30 publications

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“…A metabolic shift of DHEAS production (androgen) to Langelaan et al cortisol production (glucocorticoid) has been found to be associated with illnesses and chronic stress (38,39) and might thus be associated with burnout as well. On the other hand, work engagement may be associated with a shift towards androgen production.…”

mentioning

confidence: 99%

Do burned-out and work-engaged employees differ in the functioning of the hypothalamic-pituitary-adrenal axis?

Langelaan¹,

Bakker²,

Wb³

et al. 2006

Scand J Work Environ Health

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mentioning

confidence: 99%

Do burned-out and work-engaged employees differ in the functioning of the hypothalamic-pituitary-adrenal axis?

Langelaan¹,

Bakker²,

Wb³

et al. 2006

Scand J Work Environ Health

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“…This can be clarified by determining the cortisol/DHEA ratio, which may be a more appropriate measurement than DHEA alone [191]. If the biological response to stress is impaired among schizophrenia patients, it is possible that the cortisol/DHEA ratio would be elevated as a result of stress associated with the illness [192].…”

Section: Dhea In Schizophreniamentioning

confidence: 99%

Dehydroepiandrosterone (DHEA) and DHEA Sulfate: Roles in Brain Function and Disease

Quinn¹,

Robinson²,

Walker³

2018

Sex Hormones in Neurodegenerative Processes and Diseases

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Among the neuroactive steroids, dehydroepiandrosterone (3b-hydroxyandrost-5-ene-17-one, [DHEA]) and its sulfated metabolite DHEA sulfate (DHEAS) have been shown to be potent modulators of neural function, including neurogenesis, neuronal growth and differentiation, and neuroprotection. Highlighting the potential health significance of DHEA and DHEAS in humans, serum concentrations decrease steadily with age, with lowest concentrations present at the time many diseases of aging and neurodegeneration become apparent. This temporal association has led to the suggestion that pathology associated with cognitive decline, age-related neurological disorders such as Alzheimer's disease, dementia, amyotrophic lateral sclerosis (ALS), and adult onset schizophrenia may, in part at least, be attributed to decreased secretion of DHEA. Animal studies suggest neuroprotective functions for DHEA and DHEAS through reduction of glutamate-induced excitotoxicity. Reduced myelin loss and reactive gliosis after spinal cord injury by DHEA treatment also suggest a role for DHEA in the treatment of white matter pathologies such as multiple sclerosis. In this chapter, we discuss the physiological roles of DHEA and DHEAS in the central nervous system (CNS), their potential as neuroprotective hormones with reference to documented effects on excitotoxicity and oxidative stress, and their anti-glucocorticoid actions during chronic stress. The potential for metabolic derivatives of DHEA, such as estrogens and testosterone on brain function, and their contribution to neurodevelopment and neurodegenerative conditions are also discussed.

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“…DHEA is produced by the adrenal glands and is under the regulation of the HPA axis. It has been suggested that DHEA may antagonize many physiologic changes of cortisol, including enhancing immune functions [77]. The lack of appropriate DHEA levels could be a detrimental factor during aging.…”

Section: Neuroendocrine Changes In Late-life Depressionmentioning

confidence: 99%

Biomarkers in Mood Disorders Among the Elderly: Can They Contribute to Diagnosis and Prognosis?

Teixeira

Wieck

Diniz

et al. 2012

Curr Tran Geriatr Exp Gerontol Rep

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Late-life depression is one of the most common neuropsychiatric disorders in the elderly population. Its clinical presentation is heterogeneous and has some distinctive features from depression in adults. In recent years, it has been demonstrated that patients with late-life depression present significant abnormalities in several neurobiological cascades. Among them, inflammatory, neuroendocrine, and neurotrophic cascades are of paramount importance. In this review, we revise the evidence of involvement of these cascades in the pathophysiology of late-life depression and the potential of the associated molecules (such as cytokines, neurotrophic factors, and hormones) as diagnostic and prognostic biomarkers. Despite the unequivocal advance in the understanding of its neurobiological basis, to date there is no sufficient evidence to support any biomarker of late-life depression. The search for valid biomarkers of late-life depression is warranted because they may contribute to correct diagnostic classification and to predict clinical outcome.

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Relationship of dehydroepiandrosterone and cortisol in disease

Cited by 89 publications

References 30 publications

Do burned-out and work-engaged employees differ in the functioning of the hypothalamic-pituitary-adrenal axis?

Do burned-out and work-engaged employees differ in the functioning of the hypothalamic-pituitary-adrenal axis?

Dehydroepiandrosterone (DHEA) and DHEA Sulfate: Roles in Brain Function and Disease

Biomarkers in Mood Disorders Among the Elderly: Can They Contribute to Diagnosis and Prognosis?

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