Biomarkers in Mood Disorders Among the Elderly: Can They Contribute to Diagnosis and Prognosis?

Teixeira, Antônio Lúcio; Wieck, Andréa; Diniz, Breno S.; Bauer, Moisés Evandro

doi:10.1007/s13670-012-0010-9

Cited by 3 publications

(2 citation statements)

References 114 publications

(120 reference statements)

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“…Anecdotal evidence from homeusers of live helminth therapy suggest that old friend helminths may also provide protection against Parkinson's Disease and depression, although whether the latter includes geriatric depression is not known (Cheng et al, 2015). Both Parkinson's disease and geriatric depression are considered to be inflammaging-linked conditions (Teixeira et al, 2012;Calabrese et al, 2018).…”

Section: Helminth Therapy To Counter Inflammaging?mentioning

confidence: 99%

Gross Ways to Live Long: Parasitic Worms as an Anti-Inflammaging Therapy?

Zhang

2020

Preprint

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Evolutionary medicine argues that disease can arise because modern conditions do not match those in which we evolved. For example, a decline in exposure to commensal microbes and gastrointestinal helminths in developed countries has been linked to increased prevalence of allergic and autoimmune inflammatory disorders (the hygiene hypothesis). Accordingly, microbial and helminthic probiotic therapies have been explored as Darwinian treatments for these disorders. A further possibility is that loss of old friend commensals also increases the sterile, aging-associated inflammation known as inflammaging, that contributes to a range of age-related diseases, including cardiovascular disease, dementia and cancer. Interestingly, Crowe et al. (2020) recently reported that treatment with a secreted glycoprotein from a parasitic nematode can protect against murine aging by induction of anti-inflammatory mechanisms. Here, we explore the hypothesis that restorative helminth therapy would have anti-inflammaging effects. Could worm infections provide broad-spectrum protection against age-related disease?

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Section: Helminth Therapy To Counter Inflammaging?mentioning

confidence: 99%

Gross Ways to Live Long: Parasitic Worms as an Anti-Inflammaging Therapy?

Zhang

2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Anecdotal evidence from home-users of live helminth therapy suggests that old friend helminths may also provide protection against Parkinson’s disease and depression, although whether the latter includes geriatric depression is not known ( Cheng et al, 2015 ). Both Parkinson’s disease and geriatric depression are considered to be inflammaging-linked conditions ( Teixeira et al, 2012 ; Calabrese et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Gross ways to live long: Parasitic worms as an anti-inflammaging therapy?

Zhang

2021

eLife

View full text Add to dashboard Cite

Evolutionary medicine argues that disease can arise because modern conditions do not match those in which we evolved. For example, a decline in exposure to commensal microbes and gastrointestinal helminths in developed countries has been linked to increased prevalence of allergic and autoimmune inflammatory disorders (the hygiene hypothesis). Accordingly, probiotic therapies that restore ‘old friend’ microbes and helminths have been explored as Darwinian treatments for these disorders. A further possibility is that loss of old friend commensals also increases the sterile, aging-associated inflammation known as inflammaging, which contributes to a range of age-related diseases, including cardiovascular disease, dementia, and cancer. Interestingly, Crowe et al., 2020 recently reported that treatment with a secreted glycoprotein from a parasitic nematode can protect against murine aging by induction of anti-inflammatory mechanisms. Here, we explore the hypothesis that restorative helminth therapy would have anti-inflammaging effects. Could worm infections provide broad-spectrum protection against age-related disease?

show abstract