Relationship of Changes in Cystatin-C With Serum Creatinine and Estimated Glomerular Filtration Rate in Kidney Transplantation

Gompou, Athina; Περρέα, Δέσποινα; Karatzas, Theodore; Bellos, John K.; Kastania, Anastasia N.; Boletis, Ioannis; Kostakis, Alkiviadis

doi:10.1016/j.transproceed.2015.04.084

Cited by 6 publications

(3 citation statements)

References 40 publications

(20 reference statements)

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“…20 Other study reported that serum Cystatin C is a better early predictor of progression of ESRD in person with type 2 diabetes, and the ability of serum Cystatin C to detect pathologies changes in renal function is very high. 21 Other studies reported that the increase in serum Cystatin C is more than serum creatinin in kidney damage. Serum Cystatin C is not influenced by race, muscle mass, gender and age.…”

Section: Discussionmentioning

confidence: 99%

Effect of serum cystatin C in early diabetic nephropathy in type 2 Iraqi diabetic patients

2017

J. contemp. med. sci.

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Objective This study aimed to find the effect of serum Cystatin C in early diabetic nephropathy. Method This study was conducted in Al Kindy Teaching Hospital during the period from December, 2015 to June, 2016. The study included 90 subjects (30 males and 30 females) with diabetic type 2 and 30 healthy control. Age is between 30 and 70 years. Patients were with no history of liver disease, thyroid or other endocrine diseases through clinical interviewing. They were divided in to three groups. 30 healthy controls, 30 patients with type 2 diabetes mellitus with no albuminuria (albumin excretion in urine <30 µg/ml) and 30 patients with type 2 diabetes mellitus with micro albuminuria (albumin excretion in urine >30 µg/ml). Results There were no significant differences in age, body mass index (BMI) among the studied groups (p > 0.05). Serum Cystatin C levels showed significant difference (p < 0.001) among studied groups, it was significantly higher in micro albuminuria than the other two groups. There was highly significant positive correlation between Cystatin C and serum creatinine (r = 0.697, p < 0.001), and a significant negative correlation between Cystatin C and GFR (r = − 0.455, p = 0.011) and showed significant positive correlation between Cystatin C and urine albumin (r = 0.526, p = 0.003) in type 2 diabetic patients with micro albuminuria. Conclusion Cystatin C is negatively correlated with the amount of GFR, so that Cystatin C considered reliable and sensitive marker for identifying changes in GFR. In type 2 diabetes mellitus with micro albuminuria serum Cystatin C level considered predict marker for renal failure.

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Section: Discussionmentioning

confidence: 99%

Effect of serum cystatin C in early diabetic nephropathy in type 2 Iraqi diabetic patients

2017

J. contemp. med. sci.

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“…Cys-c is not easily affected by inflammation, body muscle mass, diet, body mass, renal tubular secretion. Based on these characteristics, Cys-c is currently an endogenous marker Effect of Beta-casomorphin-7 on Renal Function and Immunity in Aging Mice of glomerular filtration rate that is better than creatinine and urea nitrogen (Gompou, Perrea et al 2015). CK is one of the key enzymes in energy metabolism.…”

Section: Resultsmentioning

confidence: 99%

Effect of Beta-casomorphin-7 on Renal Function and Immunity in Aging Mice

Yin¹,

Chen²,

Su³

et al. 2021

IJAR

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Background: Most studies have shown that Beta-Casomorphin-7 (BCM-7) has many physiological functions, this study aims to investigate the effects of BCM-7 on renal function and immunity in naturally aging mice and to reveal the effects of BCM-7 on health and provide more theoretical reference for inflammatory aging.Methods: All mice were weighed weekly and the organ indexes were calculated, Paraffin sections were prepared for kidney histopathological examination with conventional Haematoxylin and Eosin (HE) staining, renal function indexes and cytokines were main measured by ELISA and biochemical colorimetry.Result: The weight of each group increased during gastric perfusion and the higher the intervention concentration, the lower the weight gain rate. The renal index was not affected by BCM-7, but the spleen index was significantly decreased by medium-dose BCM-7. There were inflammatory cell infiltration and other renal lesions in the aging control group and intervention group. A medium dose of BCM-7 can significantly reduce Cystatin C (Cys-C) content in aging mice, the content of Adrenocorticotropic hormone (ACTH) in aged mice decreased with the increase of BCM-7 intervention dose. BCM-7 and aging caused cytokine imbalance in mice.

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“…Serum Cys-C can freely pass through the glomerulus without being secreted by the renal tubules [13]. Gompou et al [14] reported that mild changes in the estimated glomerular filtration rate (eGFR) caused an increase in serum Cys-C, whereas serum creatinine increased only when the eGFR decreased more significantly. The renal toxicity of hyperuric acid can lead to glomerular damage and a decrease in the eGFR.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Serum Cystatin C Level and Retinal Blood Flow in Patients with Essential Hypertension

et al. 2022

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Introduction: Hypertension is known to impact the structure and function of the ocular vascular system and is an established risk factor for many eye diseases. This study aimed to detect the blood flow in the optic disc and macula in patients with essential hypertension and to analyze its correlation with serum cystatin C (Cys-C) levels. Methods: This single center, cross-sectional study included 100 patients with primary hypertension without hypertensive retinopathy, who were divided into an experimental group (50 cases, 50 eyes) with elevated serum Cys-C levels and a control group (50 cases, 50 eyes) with normal serum Cys-C . The optic disc and macular vessel density (VD) and vascular perfusion density (PD) were assessed using optical coherence tomography angiography (OCTA). Data such as the area, perimeter, and circularity of the foveal avascular zone (FAZ) were analyzed. Results: There were statistically significant between-group differences in the VD and PD of the optic disc (P<0.05). Spearman correlation analysis of related indicators revealed that serum Cys-C was positively correlated with creatinine, uric acid, and FAZ circularity (P<0.05). Furthermore, serum Cys-C was negatively correlated with optic disc VD and PD in some regions(P<0.05). Conclusion: In patients with essential hypertension, serum Cys-C is negatively correlated with VD and PD in the inner layer of the optic disc (zone 10).

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Relationship of Changes in Cystatin-C With Serum Creatinine and Estimated Glomerular Filtration Rate in Kidney Transplantation

Cited by 6 publications

References 40 publications

Effect of serum cystatin C in early diabetic nephropathy in type 2 Iraqi diabetic patients

Effect of serum cystatin C in early diabetic nephropathy in type 2 Iraqi diabetic patients

Effect of Beta-casomorphin-7 on Renal Function and Immunity in Aging Mice

Correlation between Serum Cystatin C Level and Retinal Blood Flow in Patients with Essential Hypertension

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