Relationship of aortic knob width with cardio-ankle vascular stiffness index and its value in diagnosis of subclinical atherosclerosis in hypertensive patients: a study on diagnostic accuracy

Korkmaz, Levent; Erkan, Hakan; Korkmaz, Hatice Ayça Ata; Acar, Zeydin; Ağaç, Mustafa Tarık; Bektaş, H.; Akyüz, Ali Rıza; Adar, Adem; Çelık, Şükrü

doi:10.5152/akd.2012.034

Cited by 20 publications

(25 citation statements)

References 21 publications

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“…A significant doseresponse relationship between aortic knob width and AHI was observed. Second, there was a significant correlation between aortic knob width and the arterial stiffness parameter, CAVI, which is consistent with the report of another study including 374 patients with hypertension 10) . Third, multivariate regression analysis revealed that in patients with OSA, AHI was associated with aortic knob width independent of CAVI.…”

Section: Resultssupporting

confidence: 90%

Aortic Knob Width as a Novel Indicator of Atherosclerosis and Obstructive Sleep Apnea

Tomita

Kasai

Ishiwata

et al. 2020

JAT

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Patients with obstructive sleep apnea (OSA) are likely to show increased arterial stiffness and progressive systemic atherosclerosis. Chest radiography reveals atherosclerotic changes in the aorta via measurement of aortic knob width. However, to our knowledge, aortic knob width in patients with OSA has never been evaluated. Methods: We measured the aortic knob width in chest radiographs of 549 patients (age: 52.5 13.2 years; 69 women) who underwent overnight polysomnography. Moreover, we evaluated the association between aortic knob width and other clinical characteristics, including cardioankle vascular index (CAVI) and apneahypopnea index (AHI). Multivariate linear regression analysis was conducted to identify factors associated with aortic knob width. Results: A significant direct correlation between aortic knob width and CAVI and between aortic knob width and AHI was observed. In multivariate linear regression analysis, either CAVI or AHI was independently associated with aortic knob width (p 0.004 and p 0.001, respectively) in addition to age, male gender, body mass index, and systolic blood pressure. Conclusion: A significant independent correlation between aortic knob width and OSA severity was observed. Our findings suggest that an increase in the aortic knob width suggests atherosclerotic changes in the aorta and may be associated with OSA and increased arterial stiffness. dative stress 3) , which is caused by repetitive episodes of intermittent hypoxia and reoxygenation associated with apneas and hypopneas. Moreover, increased oxidative stress may facilitate atherosclerosis by impairing endothelial function and enhancing the inflammatory cascade, which further stiffens the arteries 4). Indeed, arterial stiffness parameters, such as pulse wave velocity and cardioankle vascular index (CAVI), are elevated in patients with OSA 5, 6). Additionally, repetitive respiratory efforts during obstructive apneas increase negative intrathoracic pressure 7). This negative intra

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Section: Resultssupporting

confidence: 90%

Aortic Knob Width as a Novel Indicator of Atherosclerosis and Obstructive Sleep Apnea

Tomita

Kasai

Ishiwata

et al. 2020

JAT

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“…reported that a cut‐off level of 8.81 for CAVI yielded maximal sensitivity and specificity for coronary artery disease . We therefore defined increased arterial stiffness as abnormal CAVI (≥9), as was done in a previous study …”

Section: Methodsmentioning

confidence: 99%

“…15 We therefore defined increased arterial stiffness as abnormal CAVI (≥9), as was done in a previous study. 16…”

Section: Measurementsmentioning

confidence: 99%

Association between hemoglobin levels and arterial stiffness for general Japanese population in relation to body mass index status: The Nagasaki Islands study

Shimizu

Nakazato

Sekita

et al. 2013

Geriatrics & Gerontology International

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“…Abnormal CAVI represents subclinical atherosclerosis. ba-PWV ≥ 17.5 m/sec was considered abnormal [ 39 , 40 ]. For the study, the higher obtained CAVI and ba-PWV were considered.…”

Section: Measurementsmentioning

confidence: 99%

Leukocyte Subtype Counts and Its Association with Vascular Structure and Function in Adults with Intermediate Cardiovascular Risk. MARK Study

Gómez‐Sánchez¹,

Patino-Alonso²,

Agudo‐Conde

et al. 2015

PLoS ONE

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ObjectivesWe investigated the relationship between leukocyte subtype counts and vascular structure and function based on carotid intima-media thickness, pulse wave velocity, central augmentation index and cardio-ankle vascular index by gender in intermediate cardiovascular risk patients.MethodsThis study analyzed 500 subjects who were included in the MARK study, aged 35 to 74 years (mean: 60.3±8.4), 45.6% women. Measurement: Brachial ankle Pulse Wave Velocity (ba-PWV) estimate by equation, Cardio-AnkleVascular Index (CAVI) using the VaSera device and Carotid ultrasound was used to measure carotid Intima Media Thickness (IMT). The Mobil-O-Graph was used to measure the Central Augmentation Index (CAIx).ResultsTotal leukocyte, neutrophil and monocyte counts were positively correlated with IMT (p < 0.01) in men. Monocyte count was positively correlated with CAIx in women (p < 0.01). In a multiple linear regression analysis, the IMT mean maintained a positive association with the neutrophil count (β = 1.500, p = 0.007) in men. CAIx maintained a positive association with the monocyte count (β = 2.445, p = 0.022) in women.ConclusionThe results of this study suggest that the relationship between subtype circulating leukocyte counts and vascular structure and function, although small, may be different by gender. In men, the neutrophil count was positively correlated with IMT and in women, the monocyte count with CAIx, in a large sample of intermediate-risk patients. These association were maintained after adjusting for age and other confounders.Trial RegistrationClinicalTrials.gov NCT01428934

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Relationship of aortic knob width with cardio-ankle vascular stiffness index and its value in diagnosis of subclinical atherosclerosis in hypertensive patients: a study on diagnostic accuracy

Cited by 20 publications

References 21 publications

Aortic Knob Width as a Novel Indicator of Atherosclerosis and Obstructive Sleep Apnea

Aortic Knob Width as a Novel Indicator of Atherosclerosis and Obstructive Sleep Apnea

Association between hemoglobin levels and arterial stiffness for general Japanese population in relation to body mass index status: The Nagasaki Islands study

Leukocyte Subtype Counts and Its Association with Vascular Structure and Function in Adults with Intermediate Cardiovascular Risk. MARK Study

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