Japanese men aged 36-79 years undergoing a general health check.Methods: We investigated the associations between atherosclerosis/arterial stiffness, evaluated by means of CIMT and CAVI, and diabetes for all subjects, who were divided 10 into tertiles according to TG-HDL levels. Diabetes was defined as HbA 1c (NGSP) ≥6.5 %, and/or initiation of glucose-lowering medication or insulin therapy.Results: Of the130 diabetes patients identified in the cohort, 56 patients had high TG-HDL (high TG-HDL diabetes) and 43 had low TG-HDL (low TG-HDL diabetes).We found that only diabetic patients with high TG-HDL were at a significant risk for 15 atherosclerosis (diagnosed as CIMT≥1.1 mm) and increased arterial stiffness (diagnosed as CAVI ≥8.0). The multivariable-adjusted odds ratios and 95 % confidence intervals of atherosclerosis and increased arterial stiffness for diabetes were 2.67 (95%CI:1.35-5.28) and 2.36 (95%CI:1.01-5.50), for total TG-HDL diabetes 2.57(95%CI:1.32-5.02) and 3.56(95%CI: 1.50-8.46) for high TG-HDL diabetes, and 1.17(95%CI:0.52-2.63) and 0.80(95%CI:0.33-1.90) for low TG-HDL diabetes, respectively.
BackgroundPrevious studies have reported an inverse association between height and risk of cardiovascular disease. However, evidence is limited for the association between risk of atherosclerosis and height. Further, although the association between atherosclerosis and body mass index (BMI) is reportedly positive, there have been no reports of studies on associations between height and atherosclerosis in relation to BMI.MethodsWe conducted a cross-sectional study of Japanese men aged 30 to 89 years undergoing general health check-ups.ResultsOf the 1,337 men, 312 were diagnosed with carotid atherosclerosis (carotid intima-media thickness (CIMT) ≥ 1.1 mm), but no significant association was found between height and carotid atherosclerosis for the entire study group. Stratification by BMI status of those analytical findings disclosed a significant inverse association between height and carotid atherosclerosis among overweight (BMI ≥ 25 kg/m2) but not among non-overweight (BMI < 25 kg/m2) men. The classical cardiovascular risk factors-adjusted odds ratio (OR) and 95% confidence interval (CI) of carotid atherosclerosis for an increment of one SD (standard deviation) in height (6.70 cm) were 0.71 (0.54 to 0.94) for overweight (BMI ≥ 25 kg/m2) and 1.05 (0.87 to 1.27) for non-overweight (BMI < 25 kg/m2) men.ConclusionIndependent from classical cardiovascular risk factors, height was found to be inversely associated with carotid atherosclerosis for overweight but not for non-overweight men.
Objective The hemoglobin levels and blood pressure has been reported in a few studies, and a positive association between the hemoglobin levels and the body mass index (BMI) status has also been documented. A higher BMI may therefore affect the association between the hemoglobin levels and hypertension. However, no published studies have examined this association in relation to the BMI status. The primary purpose of this study was to assess the association between the hemoglobin levels and hypertension in relation to the BMI status. Methods A cross-sectional study of 3,203 non-anemic subjects (1,191 men and 2,012 women, 30-79 years old) who were undergoing general health checkups was conducted. Results A positive association between the hemoglobin levels and hypertension was established for both men and women. For a one SD (standard deviation) increment in hemoglobin, the multivariable odds ratio (ORs) and 95% confidence interval (CIs) for hypertension were 1.21 (95%CI: 1.05-1.40) for men and 1.25 (95%CI: 1.13-1.39) for women. We also found that a significant association was confined to the participants with a BMI of <25 kg/m 2 . Among the participants with a BMI of <25 kg/m 2 , the multivariable ORs and 95% CIs for hypertension of a one SD increment in hemoglobin were 1.34 (95%CI: 1.12-1.60) for men and 1.31 (95%CI: 1.16-1.47) for women. Meanwhile, among those with a BMI of ! 25 kg/m 2 , the corresponding values were 1.01 (95%CI: 0.79-1.30) and 1.09 (95%CI: 0.87-1.37). Conclusion An independent positive association between the hemoglobin levels and the risk of hypertension was observed for both non-anemic Japanese men and women, confined to participants with a BMI of <25 kg/m 2 .
Independent positive associations between hemoglobin levels and increased arterial stiffness were observed both for Japanese men and women, and those associations were limited to participants with BMI <25 kg/m(2) .
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.