Relationship of Amyloid to Aging

Wright, John; Calkins, Evan; Breen, William J.; Stolte, Gisela; Schultz, R. T.

doi:10.1097/00005792-196901000-00002

Cited by 114 publications

(13 citation statements)

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“…This is in good agreement with the reported occurrence of amyloid degeneration in other organs (Pirani 1976, Thung 1957, Wright et al 1969. Also in the present material heavier amyloid depositions could be demonstrated among the oldest patients (Table 1).…”

Section: 'supporting

confidence: 93%

Amyloid in Osteoarthritic Hip Joints:Depositions In Cartilage And Capsule. Semiquantitative Aspects

Ladefoged

1982

Acta Orthopaedica Scandinavica

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Section: 'supporting

confidence: 93%

Amyloid in Osteoarthritic Hip Joints:Depositions In Cartilage And Capsule. Semiquantitative Aspects

Ladefoged

1982

Acta Orthopaedica Scandinavica

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“…Two monkeys have shown a loss of pancreatic islets of Langerhans with replacement by eosinophilic, amorphous, amyloid-like material. The appearance of amyloid in the islets of Langerhans is also associated with aging in man, 46 -47 more so in diabetics,* 8 and has also been noted in monkeys (M. fascicularis) . 49 Autopsies of the pancreas of other M. nigra monkeys have shown most with intact islets of Langerhans.…”

Section: Io85mentioning

confidence: 95%

Spontaneous Diabetes in Macaca Nigra

Howard

1972

Diabetes

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In a closed breeding colony of Macaca nigra (black Celebes apes) there was a marked proclivity for a spontaneous diabetic-like state closely analogous to human diabetes. Numerous diabetic signs were present, including abnormal intravenous and oral glucose tolerance tests, hyperglycemia, impaired insulin response, hypertriglyceridemia, increased prebetalipoprotein, retinal vascular aberrations, abnormalities in the islets of Langerhans, and pronounced weight loss in a few severely diabetic monkeys. A classification of diabetic status established primarily on deviation of the intravenous glucose tolerance test from results in normal Celebes apes places over 50 per cent of these interrelated monkeys in nonnormal categories. DIABETES 21: 1077 -90, November, 1972

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“…A point that deserves further consideration is whether dystrophic amyloidosis could affect structures other than the heart valves. The question arises for atheromatous lesions, whether situated at the base of the heart valve as was observed in one of our surgical specimens or in the aortae as was described by Wright et al (1969). These authors were, however, unable to demonstrate any significant relationship between the presence of amyloid and the degree of atherosclerosis.…”

Section: Discussionmentioning

confidence: 64%