Relationship of alcohol intake and sex steroid concentrations in blood in pre- and post-menopausal women: the European Prospective Investigation into Cancer and Nutrition

Rinaldi, Sabina; Peeters, Petra H.M.; Bezemer, Irene D.; Dossus, Laure; Biessy, Carine; Sacerdote, Carlotta; Berrino, Franco; Panico, Salvatore; Palli, Domenico; Tumino, Rosario; Khaw, Kay Tee; Bingham, Sheila; Allen, N. E.; Key, Timothy J.; Jensen, Majken K.; Overvad, Kim; Olsen, Anja; Tjønneland, Anne; Amiano, Pilar; Ardanaz, Eva; Agudo, Antonio; Martínez‐García, Carmen; Quiŕos, J. Ramón; Tormo, María José; Nagel, Gabriële; Linseisen, Jakob; Boeing, Heiner; Schulz, Mandy; Grobbee, Diederick E.; Bueno-De-Mesquita, H. Bas; Koliva, Maria; Kyriazi, G.; Thrichopoulou, A.; Boutron‐Ruault, Marie‐Christine; Clavel‐Chapelon, Françoise; Ferrari, Pietro; Slimani, Nadia; Saracci, Rodolfo; Riboli, Elio; Kaaks, Rudolf

doi:10.1007/s10552-006-0041-7

Cited by 109 publications

(99 citation statements)

References 46 publications

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“…However, some large studies have succeeded in detecting associations between potential breast cancer risk factors and sex hormone levels using untimed blood samples (45)(46)(47). We also confirmed some of these associations in our dataset (34,35).…”

Section: Discussionsupporting

confidence: 83%

Associations of Acrylamide Intake with Circulating Levels of Sex Hormones and Prolactin in Premenopausal Japanese Women

Nagata

Konishi

Tamura

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: It has been hypothesized that alteration of hormone systems is involved in the carcinogenesis of acrylamide. The aim of the present study was to examine the cross-sectional associations between dietary acrylamide intake and sex hormone levels in premenopausal Japanese women.Methods: Study subjects were 393 women who had regular menstrual cycles less than 40 days long. Acrylamide intake was assessed with a food-frequency questionnaire and was based on acrylamide concentration reported from analyses of Japanese foods. We measured the plasma concentrations of estradiol, testosterone, dehydroepiandrosterone sulfate, sex hormonebinding globulin, follicle-stimulating hormone, luteinizing hormone, and prolactin.Results: After controlling for age, the phase of the menstrual cycle, and other covariates, acrylamide intake was statistically

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Section: Discussionsupporting

confidence: 83%

Associations of Acrylamide Intake with Circulating Levels of Sex Hormones and Prolactin in Premenopausal Japanese Women

Nagata

Konishi

Tamura

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…There are several biological mechanisms through which alcohol might increase the risk of endometrial cancer development. Alcohol has been shown to increase the levels of estrogen (1)(2)(3)(4)(5), which in turn, have been shown to increase endometrial cancer risk by stimulating the proliferation of endometrial cells (27). However, moderate alcohol intake has also been shown to improve insulin sensitivity and reduce fasting insulin concentrations (28).…”

Section: Resultsmentioning

confidence: 99%

“…Alcohol consumption has been positively associated with higher estrogen levels among postmenopausal women (1)(2)(3)(4)(5) and could therefore be expected to increase the risk of endometrial cancer. Alcohol consumption has been investigated in several epidemiologic studies, most showing no association (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18), some showing positive associations (19)(20)(21)(22), and some negative associations (23,24).…”

Section: Introductionmentioning

confidence: 99%

Long-term Alcohol Consumption and Risk of Endometrial Cancer Incidence: A Prospective Cohort Study

Friberg¹,

Wolk²

2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Alcohol consumption has been hypothesized to increase the risk of endometrial cancer. We used data from the prospective population-based Swedish Mammography Cohort including 61,226 women to examine the association between alcohol and endometrial cancer incidence. Alcohol consumption was assessed with validated food frequency questionnaires at baseline 1987 to 1990 and at follow-up in 1997. During a mean follow-up of 17.6 years, 687 endometrial cancer cases were identified in the Swedish cancer registries. We found no association between alcohol consumption and endometrial cancer risk after adjustment for age, body mass index, and smoking. The multivariable rate ratios (95% confidence intervals) for the three upper categories of long-term alcohol consumption as compared with no consumption were 1.01 (0.84-1.22) for <3.4 g/d, 1.01 (0.80-1.27) for 3.4 to 9.9 g/d, and 1.09 (0.71-1.67) for z10 g/d, respectively. The association did not differ by age, body mass index, folic acid intake, or postmenopausal hormone use in stratified analysis. In conclusion, our results suggest that low alcohol consumption (up to one drink per day) is unlikely to substantially influence risk of endometrial cancer.

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“…Although chronic, heavy consumption of alcohol can decrease free testosterone and estradiol levels, light or moderate alcohol intake can be associated with a later menopause 50 and with higher serumfree testosterone after menopause. 51 Hypercortisolism and a lowering of serum leptin can also be a consequence of chronic large intake. 52,53 Alcoholism may be accompanied by poor nutrition and exocrine pancreas insufficiency with malabsorption and vitamin D deficiency.…”

Section: Alcoholmentioning

confidence: 99%

A review of lifestyle, smoking and other modifiable risk factors for osteoporotic fractures

Abrahamsen¹,

Brask-Lindemann

Rubin

et al. 2014

BoneKEy Reports

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Although many strong risk factors for osteoporosis-such as family history, fracture history and age-are not modifiable, a number of important risk factors are potential targets for intervention. Thus, simple, non-pharmacological intervention in patients at increased risk of osteoporotic fractures could include reduction of excessive alcohol intake, smoking cessation, adequate nutrition, patient education, daily physical activity and a careful review of medications that could increase the risk of falls and fractures. There remains, however, an unmet need for high-quality intervention studies in most of these areas.

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Relationship of alcohol intake and sex steroid concentrations in blood in pre- and post-menopausal women: the European Prospective Investigation into Cancer and Nutrition

Abstract: This study supports the hypothesis of an influence of alcohol intake on sex hormone concentrations in blood.

Cited by 109 publications

References 46 publications

Associations of Acrylamide Intake with Circulating Levels of Sex Hormones and Prolactin in Premenopausal Japanese Women

Associations of Acrylamide Intake with Circulating Levels of Sex Hormones and Prolactin in Premenopausal Japanese Women

Long-term Alcohol Consumption and Risk of Endometrial Cancer Incidence: A Prospective Cohort Study

A review of lifestyle, smoking and other modifiable risk factors for osteoporotic fractures

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