Relationship of Age and Serum Immunoglobulins
to Autoantibodies against Brain Constituents in Primates

Felsenfeld, Oscar; Wolf, Robert H.

doi:10.1159/000460399

Cited by 16 publications

(4 citation statements)

References 12 publications

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“…The relationship of age and autoantibodies against brain constituents in apparently healthy humans, Macaca mulatta and Erythrocebus patas has been demonstrated in a previous communication [4], It was shown that the number of these primates with such antibodies as well as with antinuclear antibodies and rheumatic factor increased with progressing age. Furthermore, IgG and IgM antibodies to neuron cells and low molecular weight brain proteins also became demonstrable in a larger number of sera during aging.…”

Section: Introductionmentioning

confidence: 77%

“…Apparently healthy patas monkeys, belonging into the juvenile and adult age groups, have been selected. They were screened by methods described previously [4]. They were of either sex, and weighed 2-8 g. The sera of none of them contained precipitating, bactericidal and neutralizing antibodies against Sh.…”

Section: Methodsmentioning

confidence: 99%

“…Immunoglobulins and brain substances were prepared as described in the first communication [4], However, only the McPherson and Carnegie [9] low molecular brain protein but not that of Kibler and Saphira [6] was used. Only autologous organs and sera were used.…”

Section: Methodsmentioning

confidence: 99%

“…Fluorescent antibody, antinuclear antibody and rheumatic factor determinations were carried out as in previous experiments [4].…”

Section: Methodsmentioning

confidence: 99%

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Relationship of Age and Serum Immunoglobulins to Autoantibodies against Brain Constituents in Primates

Felsenfeld¹,

Rh²

1972

J Med Primatol

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Section: Introductionmentioning

confidence: 77%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Fluorescent antibody, antinuclear antibody and rheumatic factor determinations were carried out as in previous experiments [4].…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Relationship of Age and Serum Immunoglobulins to Autoantibodies against Brain Constituents in Primates

Felsenfeld¹,

Rh²

1972

J Med Primatol

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Learning and memory deficits associated with autoimmunity: Significance in aging and Alzheimer's disease

Forster¹,

Retz²,

Lal³

1988

Drug Development Research

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Forster, M.J., K.C. Retz, and H. Lal: Learning and memory deficits associated with autoimmunity: Significance in aging and Alzheimer's disease. Drug Dev. Res. 15253- 273, 1988 This review focuses on the significance of brain-reactive antibodies (BRA) to ageassociated cognitive decline and Alzheimer's disease, drawing on evidence available from both human and animal studies. Human studies suggest a relationship between BRA formation, age, and Alzheimer's disease. Experiments with mice indicate that BRA formation and age-related learning deficits are accelerated following adoptive transfer of immunity from aged to young mice. Furthermore, mice selected for autoimmunity and early formation of BRA also show accelerated, age-related learning deficits. It is concluded that a further analysis of the nature of BRA and their targets within the nervous system could reveal important immunological influences in cognitive dysfunctions related to aging and Alzheimer's disease. It is suggested that treatments that delay or prevent age-related immunological dysfunctions be evaluated for their ability to retard age-associated cognitive decline.

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Autoimmune mice as models for discovery of drugs against age‐related dementia

Lal

Forster

1991

Drug Development Research

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Lal, H., and M.J. Forster: Autoimmune mice as models for discovery of drugs against age-related dementia. Drug Dev. Res. 24:i-27, 1991. The discovery and development of drugs to treat Alzheimer's disease and other ageassociated dementias constitute an important goal of research in the pharmaceutical in-2 La1 and Forster dustry. Suitable animal models are routinely sought to expedite the discovery and development processes. The current review proposes new animal models based upon research findings from both clinical and animal investigations which suggest a neuroimmunologic component in certain age-associated dementias. Several clinical studies are discussed which suggest associations between dementia and brain-reactive autoantibodies in patients with Alzheimer's disease. In addition, studies of mice suggest that neuroimmunological, neuropathological, and behavioral characteristics of aging are accelerated in genetically autoimmune-prone mice. The learning and memory deficits of autoimmune mice are qualitatively similar to those of normal aged mice, and these deficits show similar sensitivity to pharmacologic interventions involving cholinergic and GABNbenzodiazepine systems.However, the appearance and progression of these changes with age occur more rapidly and with greater reliability in the autoimmune mice when compared with non-autoimmune strains. The studies reviewed suggest that autoimmune mice may provide a useful animal model for identification and evaluation of new drugs against learning and memory dysfunctions. In addition, the accelerated decline of learning/memory in autoimmune mice may expedite evaluation of chemical interventions designed to prevent the occurrence or arrest the progress of Alzheimer's disease and other age-associated dementias. The autoimmune models may be especially appropriate in identifying novel drugs with the immune system as a primary target.

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Relationship of Age and Serum Immunoglobulins to Autoantibodies against Brain Constituents in Primates

Cited by 16 publications

References 12 publications

Relationship of Age and Serum Immunoglobulins to Autoantibodies against Brain Constituents in Primates

Relationship of Age and Serum Immunoglobulins to Autoantibodies against Brain Constituents in Primates

Learning and memory deficits associated with autoimmunity: Significance in aging and Alzheimer's disease

Autoimmune mice as models for discovery of drugs against age‐related dementia

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