Relationship of Age and Serum Immunoglobulins
to Autoantibodies against Brain Constituents in Primates

Felsenfeld, Oscar; Rh, Wolf

doi:10.1159/000460400

Cited by 3 publications

(3 citation statements)

References 2 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These observations pointed out the parallelism of A D with systemic amyloidoses established in several autoimmune diseases such as myeloma and rheumatoid arthritis-RA (Glenner, 1980) as well as with amyloidosis of the elderly which were thought to be results of autoimmune processes (Schwartz and Kurucz, 1965). This assumption was supported by the evidence of increased levels of circulating autoantibodies against neuronal tissue in aging humans and subjects with AD as well as in aged experimental animals (Edgington and Dalessio, 1970;Felsenfeld and Wolf, 1972;Ingram, Phegan and Blumenthal, 1974;Nandy, 1978). Moreover, it was established that these occurs as a reduction of immunological competence with age (Burnet, 1970).…”

Section: Immunological Hypotheses Of Alzheimer's Diseasementioning

confidence: 91%

Importance of Immunological and Inflammatory Processes in the Pathogenesis and THERAPY of Alzheimer's Disease

Popovic

Caballero-Bleda

Puelles

et al. 1998

International Journal of Neuroscience

View full text Add to dashboard Cite

The contribution of autoimmune processes or inflammatory components in the etiology and pathogenesis of Alzheimer's disease (AD) has been suspected for many years. The presence of antigen-presenting, HLA-DR-positive and other immunoregulatory cells, components of complement, inflammatory cytokines and acute phase reactants have been established in tissue of AD neuropathology. Although these data do not confirm the immune response as a primary cause of AD, they indicate involvement of immune processes at least as a secondary or tertiary reaction to the preexisting pathogen and point out its driving-force role in AD pathogenesis. These processes may contribute to systemic immune response. Thus, experimental and clinical studies indicate impairments in both humoral and cellular immunity in an animal model of AD as well as in AD patients. On the other hand, anti-inflammatory drugs applied for the treatment of some chronic inflammatory diseases have been shown to reduce risk of AD in these patients. Therefore, it seems that anti-inflammatory drugs and other substances which can control the activity of immunocompetent cells and the level of endogenous immune response can be valuable in the treatment of AD patients.

show abstract

Section: Immunological Hypotheses Of Alzheimer's Diseasementioning

confidence: 91%

Importance of Immunological and Inflammatory Processes in the Pathogenesis and THERAPY of Alzheimer's Disease

Popovic

Caballero-Bleda

Puelles

et al. 1998

International Journal of Neuroscience

View full text Add to dashboard Cite

show abstract

“…Interest in the possibility of an autoimmune etiology for age-related dementia is based upon three important observations: 1) There is an age-related increase in frequency of BRA in sera of both humans [Felsenfeld and Wolf, 1972;Ingram et al, 1974;Nandy, 1978Nandy, , 1985Blumenthal, 1982, 1983;Elizan et al, 19831 and animals [Blumenthal et al, 1984;Nandy, 1972aNandy, , 1981Threatt et al, 1971;Feden et al, 1979;Kulmala et al, 1987;Miller and Blumenthal, 19'78;Felsenfeld and Wolf, 19721; 2) the presence of immunoglobulin and other markers of immunologic activity can be demonstrated within the CNS in aged humans and animals Blumenthal, 1982, 1983;Blumenthal, 1988;Itagaki et al, 1989;Styren et al, 19901;and 3) immunoglobulin recognizing pathologically significant targets can be demonstrated in sera or CSF of AD patients [Fillet et al, 1985[Fillet et al, , 1988Chapman et al, 1986Chapman et al, , 1988Chapman et al, , 1989aGaskin et al, 1987;Fudenberg and Singh, 1988;McRae-Degueurce et al, 1987Bahmanyar et al, 1983;Singh and Fudenberg, 19861. Detailed reviews of ,studies investigating the incidence of brain-reactive antibodies in aged humans, animals, and patients with AD have appeared recently [see Lal, 1990a, 1991;Forster et al, 19881. There is a clear indication from the literature that the incidence of BRA is increased with age, although the target antigens of BRA found in nondiseased aged individuals have not been extensively characterized.…”

Section: Autoimmunity In Aging and Alzheimer's Diseasementioning

confidence: 99%

Autoimmune mice as models for discovery of drugs against age‐related dementia

Lal

Forster

1991

Drug Development Research

View full text Add to dashboard Cite

Lal, H., and M.J. Forster: Autoimmune mice as models for discovery of drugs against age-related dementia. Drug Dev. Res. 24:i-27, 1991. The discovery and development of drugs to treat Alzheimer's disease and other ageassociated dementias constitute an important goal of research in the pharmaceutical in-2 La1 and Forster dustry. Suitable animal models are routinely sought to expedite the discovery and development processes. The current review proposes new animal models based upon research findings from both clinical and animal investigations which suggest a neuroimmunologic component in certain age-associated dementias. Several clinical studies are discussed which suggest associations between dementia and brain-reactive autoantibodies in patients with Alzheimer's disease. In addition, studies of mice suggest that neuroimmunological, neuropathological, and behavioral characteristics of aging are accelerated in genetically autoimmune-prone mice. The learning and memory deficits of autoimmune mice are qualitatively similar to those of normal aged mice, and these deficits show similar sensitivity to pharmacologic interventions involving cholinergic and GABNbenzodiazepine systems.However, the appearance and progression of these changes with age occur more rapidly and with greater reliability in the autoimmune mice when compared with non-autoimmune strains. The studies reviewed suggest that autoimmune mice may provide a useful animal model for identification and evaluation of new drugs against learning and memory dysfunctions. In addition, the accelerated decline of learning/memory in autoimmune mice may expedite evaluation of chemical interventions designed to prevent the occurrence or arrest the progress of Alzheimer's disease and other age-associated dementias. The autoimmune models may be especially appropriate in identifying novel drugs with the immune system as a primary target.

show abstract

“…Nonhuman primates respond with antibody formation to most vaccines used in man. Patas monkeys (Erythrocebus patas) are especially useful in the study of immunolo,' ~I C responses to antigens prepared from vibrios, as well as from yellow fever virus ( 2 ) . Therefore, this species was used to see whether or not antagonism between CV and yellow fever vaccine (YFV) occurs in primates other than man.…”

mentioning

confidence: 99%

Serological Responses of Patas Monkeys (Erythrocebus patas) to Vaccination Against Cholera and Yellow Fever

Felsenfeld

Wolf

Dutta

1973

Experimental Biology and Medicine

Self Cite

View full text Add to dashboard Cite

Gateff ( l ) , after examining sera from a small number of persons in Africa, stated that cholera vaccination (CV) may lower the yellow fever (YF) antibody titers and vice versa. Nonhuman primates respond with antibody formation to most vaccines used in man. Patas monkeys (Erythrocebus patas) are especially useful in the study of immunolo,' ~I C responses to antigens prepared from vibrios, as well as from yellow fever virus ( 2 ) . Therefore, this species was used to see whether or not antagonism between CV and yellow fever vaccine (YFV) occurs in primates other than man.Patas monkeys. Patas monkeys of both sexes, weighing 4-8 kg and free from signs of disease as determined by clinical, hematological, urine, stool, clinical chemistry and blood culture examination, were used. Blood samples were collected before and periodically after inoculations. The sera were stored at -20" without a preservative.Vibriocidal antibody titer ( V A ) determinations. Vibriocidal antibody titer was determined by technique of Watanabe et al. ( 3 ) using Vibrio cholerae Ogawa 41 strain. Only 3+ and 4+ reactions were recorded as positive.YeZZow fever neutralizing antibodies, The plaque-neutralization test of Spector and Tauraso (4, 5 ) was used with the 17D vaccine strain. The neutralizing titers of the sera were recorded in decimal exponents, log,, (Dex) of the highest dilution (6).All serologic tests were carried out in duplicate.Vaccination procedure. Cholera vaccination 1 Current address: Vaccine Institute, Baroda, Gujarat State, India, consisted of the intramuscular injection of 4 X lo9 phenol-killed and phenol-preserved V . cholerae Ogawa 41 organisms; vaccination against yellow fever was by the im injection of % the adult human dose of the 17D vaccine. Groups of 4 patas monkeys each were vaccinated with YFV 8, 6, 4, and 2 weeks before, simultaneously with; and 2, 4, 6, and 8 weeks after the administration of cholera vaccine, respectively. Sera were collected before vaccination, then every second week thereafter for VA and Dex determinations for 12 weeks.Evaluation. Eight patas monkeys were inoculated with CV; a second group of 8 animlals received YFV. Blood was drawn at the same intervals as the animals given both immunizing agents. The results of the VA and Dex determinations in these animals served as controls.The geometric means of the antibody titers of the monkeys in each group and the standard deviation (SD) were calculated. The difference between the means of the antibody titers in two groups was considered statistically significant approximately at the 95% level when their geometric means t, 2 SD did not overlap. The t test was used principally as a control.Results. Tables I and I1 indicate that when CV and YFV were administered simultaneously, the VA and Dex values were lower than in the respective control sera. If CV was given 2 weeks before YFV (Table I), VA titers were depressed for 4 weeks. When CV was injected 4-8 weeks before YFV, no statistically significant depressions could be shown in the titers by the calcul...

show abstract

Relationship of Age and Serum Immunoglobulins to Autoantibodies against Brain Constituents in Primates

Cited by 3 publications

References 2 publications

Importance of Immunological and Inflammatory Processes in the Pathogenesis and THERAPY of Alzheimer's Disease

Importance of Immunological and Inflammatory Processes in the Pathogenesis and THERAPY of Alzheimer's Disease

Autoimmune mice as models for discovery of drugs against age‐related dementia

Serological Responses of Patas Monkeys (Erythrocebus patas) to Vaccination Against Cholera and Yellow Fever

Contact Info

Product

Resources

About