Relationship of Age and Different Histological Types of Ovarian Tumors

Abstract

Background: Ovarian tumours are common problem in gynaecology and have varied age of appearance of different histopathological types.
 Objective: This study was undertaken to find out the relationship of age and different histological types of ovarian tumors Methods: A retrospective study was carried out in the Department of Obstetrics and Gynaecology and Department of Pathology, Sir Salimullah Medical College and Mitford Hospital, Dhaka, during May 2010 and December 2014. Five hundred forty seven (547) cases of ovarian tumours were studied in respect to their age and histopathological appearance.
 Results: The range of age of patients with ovarian tumour was 11 – 82 years. About 63% malignant and 73% benign ovarian tumours were found in the age group of 20 – 49 yrs. About 31% malignant ovarian tumours and 15% Benign tumours occurred in menopausal woman (≤50 yrs.). Overall, mean age of presentation of ovarian tumours was 34.29± 12.84 yrs. Mean age of patients with malignant ovarian tumour was 40.29± 14.28 (median 40 yrs; mode 45 yrs.). Mean age of benign ovarian tumour was 34.69 ± 13.08 (median 34 yrs; mode 40yrs) and mean age for borderline tumours 32.75 ± 11.70 mm (median 33 yrs., mode 20 yrs.). Mean age of non tumour ovarian masses / cysts was 31.14± 10.76 yrs (median 29.5; mode 25.4). The difference of mean age of occurance of malignant and benign ovarian tumours were statistically significant P<0.00>. Dysgerminoma (mean age 23.5± 4.43) and yolk sac tumour (mean age 18 .00 ± 5.00 yrs) occurred in younger patients. Serous cyst adenocarcinoma, endometriod carcinoma and poorly differentiated carcinoma occurred around 45 years of age. Mean age of presentation of most of the benign ovarian tumours was between 30 – 37 yrs.; except thecoma which occurred in extremes of age.
 Conclusion: Most of the patients with malignant and benign ovarian tumours have presented in reproductive age adult women (20 – 49 yrs.); and some specific varieties of tumour (e.g. thecoma) presented in the extremes of age.
 Bangladesh J Obstet Gynaecol, 2017; Vol. 32(2) : 99-105

Distribution of various histopathological patterns of ovarian lesions in different age groups

“…5 In the study by Begum S etal, a large number of patients harboring both benign and malignant ovarian tumors had ages between 21 and 46 years, as mentioned in Table-01. 2 In table-02, female patients presenting with non-neoplastic and benign and malignant neoplasms of ovary were belonged to ages between 21 to 50 years, as have been observed in several studies. 2,10,11 The reproductive age group harbors all variety of ovarian lesions while pre-pubertal age group harbors mostly non-neoplastic (ovarian) pathologies (Fig- 01), are same observations also made by Rasheed F etal and Northridge JL.…”

“…2 In table-02, female patients presenting with non-neoplastic and benign and malignant neoplasms of ovary were belonged to ages between 21 to 50 years, as have been observed in several studies. 2,10,11 The reproductive age group harbors all variety of ovarian lesions while pre-pubertal age group harbors mostly non-neoplastic (ovarian) pathologies (Fig- 01), are same observations also made by Rasheed F etal and Northridge JL. 3,16 Similar to other studies, current study also mentioned that follicular cysts of ovary are common non-neoplastic lesion (73.8%) and is prevalent in females during reproductive years of their lives (Table-03).…”

“…4,10,23 Similar to results of this study depicted in table-05, other studies also stated Dysgerminoma as most common malignant tumor. 2,10,11…”

“…1 A majority of patients presenting with ovarian lesions belong to late adolescence and middle-aged group. 2 The age-estimated prevalence of different ovarian pathologies is an established observation. An age is one of the independent factors in regards to the etiology, associated risks, complications and prognosis in ovarian diseases.…”

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The spectrum of ovarian pathologies embraces wide age range among females because the risk of developing ovarian lesion starts from birth and follows diverse patterns through-out the life. 1,2 The rate of development of complications, recurrence, progression to malignancy, morbidity and mortality, also varies according to the age of presentation of various ovarian pathologies. 3,4,5 The prevalence of cystic lesions of ovary is more in reproductive age group as compared to post-menopausal women.

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