Relationship of adiponectin and its multimers to metabolic indices in cats during weight change

Witzel, Angela; Kirk, Claudia A.; Kania, Stephen A.; Bartges, Joseph W.; Boston, Raymond C.; Moyers, Tamberlyn D.; Byrd, Henry C.; Lauten, Susan D.

doi:10.1016/j.domaniend.2015.05.001

Cited by 14 publications

(23 citation statements)

References 35 publications

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“…20,[56][57][58] In cats, attempts have also been made to characterize adiponectin multimer concentrations, and 2 recent studies showed preferential decreases in the HMW forms with increasing body mass. 59,60 However, in contrast with several previous results, these studies failed to find a correlation between total adiponectin concentration and body weight. Discrepancies between studies regarding the effect of obesity on adiponectin in dogs and cats 20,36,56-60 may be owing to differences in patient population, timeline and degree of obesity, or assay sensitivity and performance.…”

Section: Metabolic Effects Of Obesitycontrasting

confidence: 89%

Metabolic Effects of Obesity and Its Interaction with Endocrine Diseases

Clark

Hoenig

2016

Veterinary Clinics of North America: Small Animal Practice

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Section: Metabolic Effects Of Obesitycontrasting

confidence: 89%

Metabolic Effects of Obesity and Its Interaction with Endocrine Diseases

Clark

Hoenig

2016

Veterinary Clinics of North America: Small Animal Practice

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“…The effects of adiposity on circulating total adiponectin concentrations are controversial with some studies indicating that OC have decreased adiponectin concentrations [14–18], whereas others failed to detect differences between LC and OC in total adiponectin [19, 20]. In our study, total adiponectin concentrations across all groups showed weak negative correlation with BCS.…”

Section: Discussioncontrasting

confidence: 70%

“…There is substantial evidence that obese and insulin-resistant cats have increased circulating concentrations of leptin when compared to healthy lean cats [12, 13]. However, the association of adiponectin with obesity is inconsistent in felines with some studies indicating a negative correlation [14–18] and others failing to detect a relationship between total circulating adiponectin and obesity [19, 20]. In addition, the adipose transcript abundance of pro-inflammatory cytokines (eg., tumor necrosis factor-α, interferon-ϒ, monocyte chemoattractant protein-1) has been reported to be greater in obese compared to lean cats [21–23].…”

Section: Introductionmentioning

confidence: 99%

Differential circulating concentrations of adipokines, glucagon and adropin in a clinical population of lean, overweight and diabetic cats

et al. 2017

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BackgroundDyslipidemia, dysregulated adipokine secretion and alteration in glucagon and adropin concentrations are important obesity-related factors in the pathophysiology of human Type 2 diabetes; however, their roles in the pathophysiology of feline diabetes mellitus are relatively unknown. Here, we determined the concentrations of circulating leptin, adiponectin, pro-inflammatory cytokines, glucagon, adropin, triglycerides, and cholesterol, in non-diabetic lean and overweight cats and newly diagnosed diabetic cats. Client-owned cats were recruited and assigned into 3 study groups: lean, overweight and diabetic. Fasting blood samples were analyzed in lean, overweight and diabetic cats at baseline and 4 weeks after consumption of high protein/low carbohydrate standardized diet.ResultsSerum concentrations of triglycerides were greater in diabetics at baseline and were increased in both diabetic and overweight cats at 4 weeks. Plasma leptin concentrations were greater in diabetic and overweight at baseline and 4 weeks, whereas adiponectin was lower in diabetics compared to lean and overweight cats at baseline and 4 weeks. Diabetics had greater baseline plasma glucagon concentrations compared to lean, lower adropin than overweight at 4 weeks, and lower IL-12 concentrations at 4 weeks than baseline.ConclusionsOur results suggest that feline obesity and diabetes mellitus are characterized by hypertriglyceridemia and hyperleptinemia; however, diabetic cats have significantly lower adiponectin and adropin compared to overweight cats. Thus, despite having similar body condition, overweight and diabetic cats have differential circulating concentrations of adiponectin and adropin.

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“…Lower plasma HMW adiponectin concentrations were detected in obese cats compared to lean cats, and males had lower concentrations than females . In a recently reported study of cats undergoing weight gain or loss, HMW adiponectin was negatively correlated with body fat mass and positively correlated with glucose:insulin ratio and glucose effectiveness, a value obtained by minimal model analysis of frequently sampled intravenous glucose tolerance test data …”

Section: Discussionmentioning

confidence: 98%

“…Fasting and postprandial adiponectin profiles have been measured in healthy and obese cats using sucrose gradient centrifugation or size‐exclusion gel chromatography followed by an adiponectin‐specific ELISA. Lower HMW adiponectin concentrations were detected after feeding in healthy cats that received a high carbohydrate meal (from 3.6 ± 0.6 to 3.0 ± 0.7 l μg/mL) and fasting HMW adiponectin concentrations increased when cats were switched from a moderate (1.9 ± 0.8) to low (3.1 ± 0.7 μg/mL) carbohydrate diet .…”

Section: Discussionmentioning

confidence: 99%

Repeatability of Oral Sugar Test Results, Glucagon‐Like Peptide‐1 Measurements, and Serum High‐Molecular‐Weight Adiponectin Concentrations in Horses

Frank

Walsh²

2017

Veterinary Internal Medicne

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BackgroundRepeatability of the oral sugar test (OST) has not been evaluated.ObjectivesWe hypothesized that OST glucose, insulin, active (aGLP‐1) and total (tGLP‐1) glucagon‐like peptide 1, and high‐molecular‐weight (HMW) adiponectin results would be repeatable.AnimalsFifty‐three horses from a Tennessee research facility (n = 23) and private practice in Missouri (n = 30), including animals with medical histories of equine metabolic syndrome.MethodsTwo OSTs were performed 7–14 days apart and plasma glucose and insulin concentrations were measured at 0, 60, and 75 minutes; a positive result was defined as detection of an insulin concentration >45 μU/mL at 60 or 75 minutes. Plasma aGLP‐1 and serum tGLP‐1 concentrations at 75 minutes and serum HMW adiponectin concentrations at 0 minute were measured in the Missouri group. Bland‐Altman analyses were performed.ResultsNo adverse events were reported. Bland‐Altman analysis indicated mean ± SD bias of 1.5 ± 14.8 μU/mL (95% confidence interval [CI], −27.6 to 30.5 μU/mL) and 1.2 ± 16.1 μU/mL (95% CI, −30.4 to 32.8 μU/mL) for insulin concentrations at 60 and 75 minutes, respectively. There was 91 and 83% agreement in test interpretation between test days for OST insulin results for all horses in the Tennessee and Missouri groups, respectively.Conclusions and Clinical ImportanceRepeatability of the OST was acceptable when values obtained from Bland‐Altman analyses were evaluated, and there was good agreement in binary (negative/positive) test interpretation for insulin concentrations. However, wide 95% CIs were detected for insulin concentrations.

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Relationship of adiponectin and its multimers to metabolic indices in cats during weight change

Cited by 14 publications

References 35 publications

Metabolic Effects of Obesity and Its Interaction with Endocrine Diseases

Metabolic Effects of Obesity and Its Interaction with Endocrine Diseases

Differential circulating concentrations of adipokines, glucagon and adropin in a clinical population of lean, overweight and diabetic cats

Repeatability of Oral Sugar Test Results, Glucagon‐Like Peptide‐1 Measurements, and Serum High‐Molecular‐Weight Adiponectin Concentrations in Horses

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