Relationship of Adipokines (Adiponectin, Resistin and RBP4) with Metabolic Syndrome Components in Pubertal Obese Children

Boyraz, Mehmet; Çekmez, Ferhat; Karaoğlu, Abdülbaki; Cinaz, Peyami; Durak, Mustafa; Bideci, Aysun

doi:10.2217/bmm.13.14

Cited by 34 publications

(27 citation statements)

References 29 publications

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“…In the second stage of CKD (eGFR=60-89 mol/min/1.73 mm -2 ) (2,(16)(17)(18)(19)(20), the level of resistin increased markedly, whereas other polypeptide substances were freely filtered by the kidneys. In addition, the level of resistin was observed to increase with decreasing levels of eGFR in CKD patients.…”

Section: Discussionmentioning

confidence: 99%

“…When the serum ferritin levels were <100 ng/ml and TSAT <20%, the patients who were subjected to 10 continuous cycles of hemodialysis were administered with 100 mg iron hydroxide or were removed from the study (1)(2)(3). In addition, when serum ferritin levels were ≥800 ng/ml and TSAT ≥50%, the patients were excluded from the study.…”

Section: Methodsmentioning

confidence: 99%

“…However, there is evidence that a high dose of EPO may be associated with an increased rate of mortality. Boyraz et al (2) (2) and the inflammation inhibited the activity of EPO and, thus, erythropoiesis of CKD patients, which indicated that there may be a correlation between inflammation and EPO responsiveness in CKD patients. As changes in the levels of EPO and resistin may be involved in the occurrence and progression of CKD, the correlation between serum resistin and variability to EPO responsiveness, in tissue samples obtained from CKD patients, was investigated in the present study.…”

Section: Introductionmentioning

confidence: 97%

“…A number of studies have identified that resistin was involved in insulin resistance and metabolic syndromes in renal diseases (1)(2)(3) and CKD patients on maintenance hemodialysis often succumbed to cardiovascular and cerebrovascular complications (4). Elevation of resistin levels may serve as a marker of atherosclerosis (AS) in patients exhibiting a metabolic syndrome, indicating that resistin may be key in the occurrence and development of coronary AS (1-3) as well as demonstrating that there may be a correlation between resistin levels and heart disease in CKD patients.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of the correlation between serum resistin and the variability of erythropoietin responsiveness in patients with chronic kidney disease

Zhang

Kan

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Chronic kidney disease (CKD) is commonly accompanied by inflammation and anemia; however, the pathogenesis of CKD is unclear. Expression of resistin, a cysteine-rich secretory plasma protein, is correlated with the expression of tumor necrosis factor (TNF)-α, interleukin (IL)-6 and lipoprotein-associated phospholipase A2, indicating that resistin may be involved in inflammatory events. In addition, inflammation inhibits the activity of erythropoietin (EPO) and, thus, erythropoiesis. The aim of the present study was to analyze the correlation between serum resistin and the variability of EPO responsiveness in CKD patients. The levels of serum creatinine (SCr), C-reactive protein (CRP), total cholesterol, triglycerides, IL-6 and serum resistin were measured in the samples obtained from 138 CKD patients and healthy control subjects. The levels of serum resistin in the CKD groups with and without hemodialysis were significantly higher than those observed in the normal control group (P<0.01) and the levels of serum resistin in the hemodialysis CKD group were higher than those observed in the CKD group without dialysis (P<0.01). The levels of serum resistin in patients in the randomly selected CKD group (with hemodialysis) were positively correlated with the duration of dialysis and the levels of SCr and CRP (P<0.05), however, were negatively correlated with the estimated glomerular filtration rate. The EPO resistance index (ERI) was identified to be associated with body mass index and the levels of CRP and resistin; furthermore, EPO reactivity was correlated with the level of resistin and ERI. The levels of serum resistin were correlated with the variability in EPO responsiveness that was observed in the CKD patients. Therefore, the measurement of serum resistin may aid with understanding the mechanisms, clinical diagnosis and treatment of CKD. IntroductionChronic kidney disease (CKD), a worldwide problem with a high incidence, is commonly accompanied by inflammation and anemia. Between 6.5 and 10% of the population in developed countries suffer from various renal diseases (1). CKD is a condition, which is characterized by chronic inflammation and is hypothesized to be promoted by cytokines and oxidation reactions. The inflammation can be induced by toxins, immune complexes, microorganisms, chemical agents and complement, and is activated by the monocyte-macrophage system during which tumor necrosis factor (TNF)-α, interleukin (IL)-6 and other agents are released (1). However, the underlying pathogenesis of the numerous forms of CKD remains unclear.Expression of resistin, a cysteine-rich secretory plasma protein (molecular weight, ~12.5 kDa), is correlated with the expression of TNF-α, IL-6, lipoprotein-associated phospholipase A2 and other factors, which indicates that it may be involved in various inflammatory events. A number of studies have identified that resistin was involved in insulin resistance and metabolic syndromes in renal diseases (1-3) and CKD patients on maintenance hemodialysis often succum...

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Analysis of the correlation between serum resistin and the variability of erythropoietin responsiveness in patients with chronic kidney disease

Zhang

Kan

et al. 2015

Experimental and Therapeutic Medicine

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“…Увеличение степени ожирения сопровождается максимальным снижением адипо-нектина [18]. В настоящее время некоторыми иссле-дователями гипоадипонектинемия у детей и под-ростков рассматривается как прогностический мар-кер метаболического синдрома [20].…”

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Metabolic Effects of Adiponectine

Митрошина¹,

Вербовой²

2014

Cardiovasc Ther Prev

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Метаболические эффекты адипонектинаМитрошина Е. В., Вербовой А. Ф.ГБОУ ВПО "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации. Самара, РоссияОбсуждаются метаболические эффекты гормона адипонектина, его возможная роль в развитии метаболического синдрома, инсулино-резистентности, сахарного диабета 2 типа, атеросклероза, прогно-стические возможности адипонектина как маркера развития ише-мической болезни сердца и будущих сердечно-сосудистых собы-тий, терапевтические перспективы применения адипонектина. Ключевые слова: адипонектин, ожирение, инсулинорезистент-ность, сахарный диабет 2 типа, атеросклероз, риск сердечно-сосу-дистых событий. The metabolic effects of adiponectine are discussed and its possible role in the development of metabolic syndrome, insulin resistance, diabetes mellitus 2nd type, atherosclerosis; prognostic significance of adiponectine as a marker for ischemic heart disease and future cardiovascular events, therapeutical perspectives of adiponectine use.

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Fatty Liver Disease

Claudia¹,

Mosca²,

Alterio³

et al. 2017

Contemporary Endocrinology

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Relationship of Adipokines (Adiponectin, Resistin and RBP4) with Metabolic Syndrome Components in Pubertal Obese Children

Abstract: Adiponectin, RBP4 and, in particular, resistin levels may be used as suitable predictive biomarkers of metabolic syndrome.

Cited by 34 publications

References 29 publications

Analysis of the correlation between serum resistin and the variability of erythropoietin responsiveness in patients with chronic kidney disease

Analysis of the correlation between serum resistin and the variability of erythropoietin responsiveness in patients with chronic kidney disease

Metabolic Effects of Adiponectine

Fatty Liver Disease

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