Relationship between Visual Field Sensitivity and Macular Ganglion Cell Complex Thickness as Measured by Spectral-Domain Optical Coherence Tomography

Cho, Jung Woo; Sung, Kyung Rim; Lee, Suhwan; Yun, Sung‐Cheol; Kang, Suk‐Ju; Choi, Jaewan; Na, Jung Hwa; Lee, Youngrok; Kook, Michael S.

doi:10.1167/iovs.09-5035

Cited by 112 publications

(88 citation statements)

References 31 publications

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“…A thinner GCC was associated with lower retinal sensitivity as shown earlier in glaucoma cases. 24,25 As the GCC thickness changed in the area corresponding to the ILM peeled area, measuring not only central visual acuity but retinal sensitivity seems important to evaluate postoperative macular function after ILM peeling.…”

Section: Discussionmentioning

confidence: 99%

Reduction of thickness of ganglion cell complex after internal limiting membrane peeling during vitrectomy for idiopathic macular hole

Baba

Yamamoto

Kimoto

et al. 2012

Eye

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Section: Discussionmentioning

confidence: 99%

Reduction of thickness of ganglion cell complex after internal limiting membrane peeling during vitrectomy for idiopathic macular hole

Baba

Yamamoto

Kimoto

et al. 2012

Eye

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“…Previous studies demonstrated that GCC thickness was significantly lower in glaucomatous eyes with visual field defects than in healthy eyes [13,14]. A number of studies report a high correlation between global visual field sensitivity and GCC in glaucomatous subjects using SD-OCT [15,16].…”

Section: Introductionmentioning

confidence: 97%

Structural and functional assessment by hemispheric asymmetry testing of the macular region in preperimetric glaucoma

et al. 2013

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Purpose To investigate structural measurements of the macular area in preperimetric glaucoma (PG) patients using spectral domain optical coherence tomography with two functional measurements [10-2 Humphrey visual field (HFA) and 10-2 Microperimeter-1 (MP-1)] and by macular symmetry testing. Methods Fifteen eyes of 15 PG subjects with a retinal nerve fiber layer defect in the inferior hemisphere and 15 eyes of 15 normal control subjects were enrolled. Macular symmetry testing was performed between the superior and inferior zones by comparing zone thickness in each hemisphere. Perimetric sensitivity asymmetry was calculated with two functional measurements. Structure-function relationships between macular symmetry testing and the mean retinal sensitivity of the corresponding hemifield or perimetric sensitivity asymmetry were calculated using Spearman's rank correlation and linear regression. Results Macular zone thickness in the abnormal hemispheres was significantly less than that in normal hemispheres in PG eyes and the corresponding hemispheres in control eyes (P \ 0.001). Macular symmetry testing was significantly lower in PG eyes compared to control eyes (P \ 0.001). HFA (10-2) and MP-1 (10-2) correlated significantly (rs = 0.81, P \ 0.0001). Macular symmetry testing values were significantly correlated with perimetric sensitivity and perimetric sensitivity asymmetry with two functional measurements (rs = 0.61, P = 0.02; HFA and rs = 0.68, P = 0.006; MP-1). Conclusions Our results suggest that macular asymmetry analysis can reveal the structure-functional relationship in PG eyes.

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“…These anatomical correlates are known to diminish in thickness and volume as a result of glaucoma (monkey 18,19 , human [20][21][22][23][24][25][26][27][28][29][30][31][32][33] ). We used a Heidelberg spectral domain -optical coherence tomography (SD-OCT, Spectralis ® ) device to quantitatively measure these structures noninvasively in the living human eye.…”

Section: Fields Of Research (For) Classificationmentioning

confidence: 99%

“…However, this relationship may not be strictly linear such that early in the glaucomatous disease process, visual field performance tends to be better than that suggested from thinning of the retina and RNFL. (monkey 18,19 , human [20][21][22][23][24][25][26][27][28][29][30][31][32][33] ) By the time visual field defects are detected, up to 30% of the optic nerve can be damaged. 13,14 It is unclear why visual field performance tends to be more robust and resistant to change compared to optic nerve head structure in some patients with glaucoma.…”

Section: Secondary Study Endpointsmentioning

confidence: 99%

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Defining the structure - function horizontal meridian of the human macula

Lemor¹

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2 AbstractPurpose: To investigate the congruency of the retinal ganglion cell structure -function relationship in the macular region of human subjects who manifest horizontal split fixation due to glaucoma. Subjects with glaucoma who manifest asymmetric loss of retinal ganglion cells across the horizontal meridian macula were examined using structural measures provided by spectral domain optical coherence tomography (SD-OCT) and functional measures using automated visual field perimetry (HVF). Using this data, the horizontal meridian of the human macula was defined using structure -function linking analysis of retinal ganglion cell integrity.Methods: 26 stable glaucoma subjects who manifest split fixation on HVF 24-2 S/S testing were identified and performed Heidelberg Spectralis® SD-OCT posterior pole asymmetry analyses. The posterior pole asymmetry analysis image was oriented in a systematic manner so that the macular thickness grid was centered on the fovea and its horizontal meridian intersected the optic nerve head at five pre-selected equidistant locations along the central vertical axis. The posterior pole asymmetry analysis for each optic nerve head intercept generated average superior and inferior retinal hemifield and temporal quadrant thicknesses and the superior to inferior thickness ratio calculated. Tukey post-hoc pairwise comparisons of the hemifield and quadrant thickness ratios demonstrate a significant difference between the superior and inferior poles (p<.01). The SD-OCT thickness ratios for both the hemifield and temporal quadrants increase as the horizontal meridian migrates towards the inferior pole of the optic nerve head.Conclusions: We demonstrate that in order to maximize the hemifield ratio and the congruency of the macular structure -function relationship in subjects with glaucoma, the horizontal meridian of the posterior pole asymmetry grid should intersect the optic nerve head near the inferior pole. This is in contradistinction to the conventional practice of placing the horizontal median through the geometric center of the optic nerve head.3

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Relationship between Visual Field Sensitivity and Macular Ganglion Cell Complex Thickness as Measured by Spectral-Domain Optical Coherence Tomography

Abstract: GCCT, determined by SD-OCT, showed correlation to MS of a strength similar to that demonstrated between MS and pRNFLT.

Cited by 112 publications

References 31 publications

Reduction of thickness of ganglion cell complex after internal limiting membrane peeling during vitrectomy for idiopathic macular hole

Reduction of thickness of ganglion cell complex after internal limiting membrane peeling during vitrectomy for idiopathic macular hole

Structural and functional assessment by hemispheric asymmetry testing of the macular region in preperimetric glaucoma

Defining the structure - function horizontal meridian of the human macula

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