Relationship between total serum immunoglobulin E levels, fractional exhaled breath nitric oxide levels and absolute blood eosinophil counts in atopic and non-atopic asthma: a controlled comparative study

Drews, Arne; Sharma, Lucky; Pant, Subash; Shrestha, Sanjeev; Neopane, A

doi:10.1088/1752-7163/aa95da

Cited by 19 publications

(20 citation statements)

References 38 publications

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“…However, high concentrations of exhaled NO are seen in chronic inflammatory diseases, such as asthma, mainly due to type 2 inflammation resulting in increased activation of iNOS. Airway infections, especially rhinovirus, and allergic rhinitis are also related to higher levels of exhaled NO …”

Section: Introductionmentioning

confidence: 99%

“…Airway infections, especially rhinovirus, and allergic rhinitis are also related to higher levels of exhaled NO. 2 The measurement of fractional exhaled NO (F E NO) is a useful, non-invasive method to assist with the diagnosis of asthma and monitor treatment effects. In recent years, F E NO has been used as a marker for eosinophilic airway inflammation and asthma, 3 and to identify steroid responsiveness in individuals with chronic respiratory symptoms caused by airway inflammation.…”

Section: Introductionmentioning

confidence: 99%

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Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III

Nerpin

Olivieri

Gislason

et al. 2019

Clin Experimental Allergy

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Introduction The fractional exhaled nitric oxide (FENO) is a marker for type 2 inflammation used in diagnostics and management of asthma. In order to use FENO as a reliable biomarker, it is important to investigate factors that influence FENO in healthy individuals. Men have higher levels of FENO than women, but it is unclear whether determinants of FENO differ by sex. Objective To identify determinants of FENO in men and women without lung diseases. Method Fractional exhaled nitric oxide was validly measured in 3881 healthy subjects that had answered the main questionnaire of the European Community Respiratory Health Survey III without airways or lung disease. Results Exhaled NO levels were 21.3% higher in men compared with women P < 0.001. Being in the upper age quartile (60.3‐67.6 years), men had 19.2 ppb (95% CI: 18.3, 20.2) higher FENO than subjects in the lowest age quartile (39.7‐48.3 years) P = 0.02. Women in the two highest age quartiles (54.6‐60.2 and 60.3‐67.6 years) had 15.4 ppb (14.7, 16.2), P = 0.03 and 16.4 ppb (15.6, 17.1), P = <0.001 higher FENO, compared with the lowest age quartile. Height was related to 8% higher FENO level in men (P < 0.001) and 5% higher FENO levels in women (P = 0.008). Men who smoked had 37% lower FENO levels and women had 30% lower levels compared with never‐smokers (P < 0.001 for both). Men and women sensitized to both grass and perennial allergens had higher FENO levels compared with non‐sensitized subjects 26% and 29%, P < 0.001 for both. Conclusion and Clinical Relevance Fractional exhaled nitric oxide levels were higher in men than women. Similar effects of current smoking, height, and IgE sensitization were found in both sexes. FENO started increasing at lower age in women than in men, suggesting that interpretation of FENO levels in adults aged over 50 years should take into account age and sex.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III

Nerpin

Olivieri

Gislason

et al. 2019

Clin Experimental Allergy

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show abstract

“…The association between asthma and blood eosinophils is well known. Some studies reported that there was a positive correlation between FENO and peripheral blood eosinophils in asthma patients 26,27 . However, little is known about this correlation in patients with COPD, and some small-scale studies have shown no significant association 15,24,28 .…”

Section: Discussionmentioning

confidence: 98%

Clinical Features of Chronic Obstructive Pulmonary Disease with High Fractional Exhaled Nitric Oxide

et al. 2020

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Chronic obstructive pulmonary disease (COPD) is a globally prevalent disease with serious complications and high mortality. COPD is currently the fourth leading cause of death. Recently, its prevalence has rapidly increased and is expected to be the third leading cause of death worldwide by 2030 1. COPD is known to be a heterogeneous lung disease that includes many different phenotypes. Asthma can coexist with COPD, particularly in older adults, a condition known as "asthma COPD overlap (ACO) 2. " ACO is an inflammatory condition of both asthma and COPD, characterized by increased variability of airflow and incompletely reversible airway flow obstruction. ACO prevalence is estimated to be about 20% of

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“…5 FE NO can therefore aid asthma diagnosis, and, if correctly applied and interpreted, identify patients at risk of exacerbation. 6 In clinical practice, generalized cut-off values of FE NO have so far been difficult to translate to individual patients due to unknown contribution of factors that influence the FE NO value, such as allergen-specific immunoglobulin E level (IgE), blood eosinophil counts, 7 tobacco smoke exposure, 8 upper airway infection, age and height. 9 The interest of measuring the number of blood eosinophils has increased in recent years since the introduction of anti-interleukin-5 therapy for severe eosinophil asthma.…”

Section: Introductionmentioning

confidence: 99%

Genetic effects of allergen‐specific IgE levels on exhaled nitric oxide in schoolchildren with asthma: The STOPPA twin study

Hedman

Kuja‐Halkola

Örtqvist

et al. 2021

Pediatric Allergy Immunology

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Relationship between total serum immunoglobulin E levels, fractional exhaled breath nitric oxide levels and absolute blood eosinophil counts in atopic and non-atopic asthma: a controlled comparative study

Abstract: tIgE levels, FNO and AEC levels are higher in asthma, specifically in the atopic phenotype, as compared to normal. Total serum IgE levels have moderate correlation with FNO and AEC but FNO and AEC are weakly correlated.

Cited by 19 publications

References 38 publications

Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III

Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III

Clinical Features of Chronic Obstructive Pulmonary Disease with High Fractional Exhaled Nitric Oxide

Genetic effects of allergen‐specific IgE levels on exhaled nitric oxide in schoolchildren with asthma: The STOPPA twin study

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