Genetic effects of allergen‐specific IgE levels on exhaled nitric oxide in schoolchildren with asthma: The STOPPA twin study

Hedman, Anna M.; Kuja‐Halkola, Ralf; Örtqvist, Anne K.; Hage, Marianne van; Almqvist, Catarina; Nordlund, Björn

doi:10.1111/pai.13438

Cited by 5 publications

(3 citation statements)

References 48 publications

(62 reference statements)

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“…IgE sensitisation is a major determinant of FeNO, leading to increased FeNO values in both healthy subjects 16,[40][41][42] and subjects with rhinitis and asthma 21,23,43 . Hedman et al recently reported, in a study of mono-and dizygotic twins, that the relation between FeNO and asthma is mostly governed by genetic factors influencing IgE levels 44 . However, Olin et al suggested that increased FeNO was found in subjects with sensitisation toward airborne allergens only if they had symptoms of airway inflammation (i.e., asthma or rhinitis) 45 .…”

Section: Discussionmentioning

confidence: 99%

“…Hedman et al recently reported, in a study of mono-and dizygotic twins, that the relation between FeNO and asthma is mostly governed by genetic factors influencing IgE levels 44. However, Olin et al suggested that increased FeNO was found in subjects with sensitization towards airborne allergens only if they had symptoms of airway inflammation (ie asthma or rhinitis) 45.…”

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confidence: 99%

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Cross‐sectional study on exhaled nitric oxide in relation to upper airway inflammatory disorders with regard to asthma and perennial sensitization

Krantz

Accordini

Alving

et al. 2021

Clin Experimental Allergy

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Background: Fractional exhaled nitric oxide (FeNO) is a well-known marker of type-2 inflammation. FeNO is elevated in asthma and allergic rhinitis, with IgE sensitisation as a major determinant.Objective: We aimed to see if there was an independent association between upper airway inflammatory disorders (UAID) and FeNO, after adjustment for asthma and sensitisation, in a multi-centre populationbased study.Methods: A total of 741 subjects with current asthma and 4,155 non-asthmatic subjects participating in the second follow-up of the European Community Respiratory Health Survey (ECRHS III) underwent FeNO measurements. Sensitisation status was based on measurement of IgE against airborne allergens; information on asthma, UAID and medication was collected through interview-led questionnaires.Independent associations between UAID and FeNO was assessed in adjusted multivariate regression models and test for interaction with perennial sensitisation and asthma on the relation between UAID and FeNO were made.Results: UAID were associated with higher FeNO after adjusting for perennial sensitisation, asthma and other confounders: with 4.4 (0.9-7.9) % higher FeNO in relation to current rhinitis and 4.8 (0.7-9.2)% higher FeNO in relation to rhinoconjunctivitis. A significant interaction with perennial sensitisation was found in the relationship between current rhinitis and FeNO (p=0.03) and between rhinoconjunctivitis and FeNO (p=0.03). After stratification by asthma and perennial sensitisation, the association between current rhinitis and FeNO remained in non-asthmatic subjects with perennial sensitisation, with 12.1 (0.2-25.5) % higher FeNO in subjects with current rhinitis than in those without.Conclusions & Clinical Relevance: Current rhinitis and rhinoconjunctivitis was associated with higher FeNO, with an interaction with perennial sensitisation. This further highlights the concept of united airway disease, with correlations between symptoms and inflammation in the upper and lower airways and that sensitisation needs to be accounted for in the relation between FeNO and rhinitis.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Cross‐sectional study on exhaled nitric oxide in relation to upper airway inflammatory disorders with regard to asthma and perennial sensitization

Krantz

Accordini

Alving

et al. 2021

Clin Experimental Allergy

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“…The investigation of food allergy among twin pairs also identified genetics as a risk factor in allergy development [ 65 ]. A recent twin study also showed that a genetic component drove both asthma and allergic sensitization in children [ 66 ].…”

Section: Prenatal Risk Factors In the Development Of Allergic Diseasesmentioning

confidence: 99%

Prenatal Factors in the Development of Allergic Diseases

Grijincu,

Buzan,

Zbîrcea

et al. 2024

IJMS

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Allergic diseases are showing increasing prevalence in Western societies. They are characterized by a heightened reactivity towards otherwise harmless environmental stimuli. Allergic diseases showing a wide range of severity of symptoms have a significant impact on the quality of life of affected individuals. This study aims to highlight the mechanisms that induce these reactions, how they progress, and which prenatal factors influence their development. Most frequently, the reaction is mediated by immunoglobulin E (IgE) produced by B cells, which binds to the surface of mast cells and basophils and triggers an inflammatory response. The antibody response is triggered by a shift in T-cell immune response. The symptoms often start in early childhood with eczema or atopic dermatitis and progress to allergic asthma in adolescence. An important determinant of allergic diseases seems to be parental, especially maternal history of allergy. Around 30% of children of allergic mothers develop allergic sensitization in childhood. Genes involved in the regulation of the epithelial barrier function and the T-cell response were found to affect the predisposition to developing allergic disorders. Cord blood IgE was found to be a promising predictor of allergic disease development. Fetal B cells produce IgE starting at the 20th gestation week. These fetal B cells could be sensitized together with mast cells by maternal IgE and IgE–allergen complexes crossing the placental barrier via the low-affinity IgE receptor. Various factors were found to facilitate these sensitizations, including pesticides, drugs, exposure to cigarette smoke and maternal uncontrolled asthma. Prenatal exposure to microbial infections and maternal IgG appeared to play a role in the regulation of T-cell response, indicating a protective effect against allergy development. Additional preventive factors were dietary intake of vitamin D and omega 3 fatty acids as well as decreased maternal IgE levels. The effect of exposure to food allergens during pregnancy was inconclusive, with studies having found both sensitizing and protective effects. In conclusion, prenatal factors including genetics, epigenetics and fetal environmental factors have an important role in the development of allergic disorders in later life. Children with a genetic predisposition are at risk when exposed to cigarette smoke as well as increased maternal IgE in the prenatal period. Maternal diet during pregnancy and immunization against certain allergens could help in the prevention of allergy in predisposed children.

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Twin studies of cardiorespiratory disease, daily cardiovascular activity and imaging

Tárnoki

Geus

Tárnoki

2022

Twin Research for Everyone

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Genetic effects of allergen‐specific IgE levels on exhaled nitric oxide in schoolchildren with asthma: The STOPPA twin study

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 5 publications

References 48 publications

Cross‐sectional study on exhaled nitric oxide in relation to upper airway inflammatory disorders with regard to asthma and perennial sensitization

Cross‐sectional study on exhaled nitric oxide in relation to upper airway inflammatory disorders with regard to asthma and perennial sensitization

Prenatal Factors in the Development of Allergic Diseases

Twin studies of cardiorespiratory disease, daily cardiovascular activity and imaging

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