Relationship between total iron binding capacity and transferrin concentration in neonatal piglets treated with iron-dextran

Abstract

Serum iron concentration and iron saturation of transferrin (Trf) are measures of body iron stores after administration of iron supplements. In clinical and experimental research, the complex determination of Trf was replaced by the simple determination of total iron binding capacity (TIBC). The objective of this work was to define if TIBC could be an adequate measure for Trf in neonatal piglets after i.m. iron administration. Treated piglets received 150 mg of iron-dextran i.m. the first day of life, and were compared to the untreated control group. Prior to iron administration, as well as on days 2, 8 and 12 after iron administration, serum iron and TIBC concentration were analyzed by an automatized chemical analyzer and Trf was determined by densitometry of electrophoretic strips. Our results show that regardless of iron treatment, TIBC is not a measure of Trf concentration in neonatal piglets two days after birth. At day 8 of their life a high correlation coefficient of these two parameters was established in non-treated animals, while in iron-treated piglets the same correlation was established 12 days after iron treatment. Thus, we suggest that in neonatal piglets, TIBC could be used as a measure of Trf concentration only 12 days after i.m. iron treatment

Honamli Goats Breed in South of Turkey I- Serum Mineral Analysis

“…For this reason, TIBC is considered as an indirect measure of Tf concentration. While a small number of studies have been found related with Tf level (Thoren-Tholling and Martinsson, 1974;Lampreave and Pineiro, 1992;Ilic et al, 2006), many other researchers (Kozat et al, 2006;Eltain 2008;Merhan and Ozcan, 2010;AL-Dujaily and AL-Hadithy, 2014) prefer to use the TSAT value in their study.…”