Relationship between total homocysteine, total cholesterol and creatinine levels in overt hypothyroid patients

Abstract

Hypothyroidism is associated with an increased risk for cardiovascular disease, which can not be fully explained by the atherogenic lipid profile, particularly total cholesterol and LDL-C, and other pathogenic factors may be involved. Plasma total homocysteine (tHcy) is an independent risk factor for cardiovascular disease and accelerated atherosclerosis. The aim of this study was to investigate the serum total homocysteine (tHcy) levels and its relation to total cholesterol, creatinine and thyroid hormones fT3, fT4 and TSH levels in overt hypothyroid patients compared to control subjects. In this study thirty recently diagnosed, non-treated overt hypothyroid patients (f=27, m=3) and twenty normal volunteers control (f=18, m=2) were included and subjected to determination of serum tHcy by enzyme immunoassay (EIA) technique, fT3, fT4 and TSH by Elecsys cobas e 601 analyzer, total cholesterol by enzymatic method and creatinine by kinetic method. The data was statistically analysed by SPSS-10 and p values less than 0.05 were considered significant.Our results showed that there were a significant increase of tHcy, TSH, T.cholesterol and creatinine levels by 113%, 12-folds, 58% and 54%, respectively, and a significant decrease of fT4 and fT3 levels by 49.6% and 56.4% , respectively, in hypothyroid patients than in control group. For tHcy (Mean±SD, 24.45±5.50 μmol/l vs 11.48±3.03 μmol/l, respectively; P < 0.001). tHcy was significantly positively correlated with TSH, creatinine and age and negatively correlated with free thyroxine (fT4) and no significant correlations with fT3 and T.cholesterol. In conclusion, our study confirmed the observation of elevated serum tHcy, T.cholesterol and creatinine in overt hypothyroidism and the presence of an inverse relation between tHcy with fT4 and a positive relation with TSH.

Potential harmful correlation between homocysteine and low-density lipoprotein cholesterol in patients with hypothyroidism

“…Conversely, several other investigations demonstrated that Hcy was nonsignificantly correlated with the TC level in overt hypothyroid patients ( r  = 0.288, P  = 0.12). [36] However, HHcy and LDL-C were both associated with endothelial dysfunction and cardiovascular disease. In our study, elevated plasma levels of Hcy promoted LDL-C, and the LDL-C level was also increased in HHcy patients.…”

Effect of aqueous extract of Murraya koenigii on haematological, hormonal and lipid profile of Albino rats

“…Studies on this subject confirm the presence of an inverse relationship between thyroxin serum levels and cholesterol [46]. Other studies demonstrate the influence of iodothyronine on the catabolism of the very-lowdensity lipoprotein, showing increase in LDL and very-low-density lipoprotein fractions in untreated hypothyroidism [47].…”

“…In another study, it is reported that hyperthyroidism induced a decrease in serum cholesterol. However, no alterations were reported in hypothyroidism and euthyroidism [46].…”

A hidden cause of infertility in hypothyroid patients

“…24 Moreover, hypothyroidism has always been associated with low folic acid level and a state of hyperhomocysteinemea (more than 100%). 25 Experimental studies showed that MTHFR activity was low in hypothyroidism and high in hyperthyroidism. 26 In addition to fortifying food with folate, the US Preventive Services Task Force recommends that all women be prescribed multivitamins containing folic acid at least 1 month prior to conception to prevent neural tube defects, 27 and increase a woman's chances of becoming pregnant.…”