A hidden cause of infertility in hypothyroid patients

Allam, Magdy Mohamed; El‐Zawawy, Hanaa Tarek; Barakat, S S; Ahmed, Soha Magdy; Saleh, Rasha Noureldin M.

doi:10.1002/ccr3.2654

Cited by 5 publications

(5 citation statements)

References 31 publications

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“…A patient with a history of several miscarriages and hypothyroidism was treated with low dose aspirin, enoxaparin, LT4 (levothyroxine) and folic acid (5 mg/day), but she still faced two miscarriages at the 14th week of gestation. MTHFR testing identified the patient to be 1298A>C homozygous, and a change from folate to 5-MTHF and cobalamin in this patient resulted in a successful birth [86]. From these evidences, it is clear that MTHFR genotyping can help in the management of RPL and also in ensuring successful birth in pregnancy loss patients.…”

Section: Discussionmentioning

confidence: 82%

MTHFR 1298A>C Substitution is a Strong Candidate for Analysis in Recurrent Pregnancy Loss: Evidence from 14,289 Subjects

et al. 2021

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We undertook meta-analyses on MTHFR 1298A>C substitution for critically evaluating its association with recurrent pregnancy loss (RPL). MTHFR genotype data for 5888 cases and 8401 controls from 39 studies were pooled to perform this meta-analyses. Genotype data were screened, scrutinized, pooled, analysed and subjected to sensitivity analysis to carefully evaluate the association between MTHFR 1298A>C and recurrent pregnancy loss. Genetic associations were sought using dominant, recessive and co-dominant models of genetic testing with odds ratio and 95% Confidence interval (CI) as the effect measures. Further analyses were undertaken by classifying the studies into Caucasian and East Asian sub-groups. Genetic heterogeneity was tested before pooling the data across studies. For assessing publication bias, Egger's intercept test was undertaken. We found a significant association of 1298A>C substitution with increased risk of RPL in the dominant (P=0.000; OR = 1.58; 95% CI =1.25-1.99) as well as recessive (P=0.000; OR = 1.66; 95% CI =1.25-2.20) models. In sub-group analysis, we observed a significant association of the polymorphism with RPL in the Caucasian populations using dominant (P=0.000; OR = 1.98; 95% CI =1.42-2.76) and recessive (P=0.000; OR = 2.20; 95% CI =1.49-3.24) models. However, this substitution showed no association with RPL in the East Asian populations (P=0.149; OR = 1.187; 95% CI =0.94-1.50). MTHFR 1298A>C substitution shows association with the risk of recurrent pregnancy loss. The association is in a population-specific manner with the substitution being a strong risk factor only in the Caucasian populations.

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Section: Discussionmentioning

confidence: 82%

MTHFR 1298A>C Substitution is a Strong Candidate for Analysis in Recurrent Pregnancy Loss: Evidence from 14,289 Subjects

et al. 2021

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“…One conference abstract ( 35 ) was excluded due to a lack of detailed information. A case report ( 7 ) and three ( 20 , 27 , 29 ) case-only studies were deleted. A case-control study was excluded because the data were unusable ( 36 ).…”

Section: Resultsmentioning

confidence: 99%

“…Thyroid dysfunction is associated with several adverse perinatal outcomes in the mother and fetus, including infertility, miscarriage, hypertensive disorders, premature delivery, and decreased IQ in the offspring (3,4). Recently, several clinical and epidemiological studies have shown a relationship between methylenetetrahydrofolate reductase (MTHFR) polymorphisms and thyroid dysfunction (5)(6)(7). One of the publications reported that two women diagnosed with Hashimoto's thyroiditis suffered from infertility, and in both, MTHFR gene polymorphisms were identified (7).…”

Section: Introductionmentioning

confidence: 99%

“…Recently, several clinical and epidemiological studies have shown a relationship between methylenetetrahydrofolate reductase (MTHFR) polymorphisms and thyroid dysfunction (5)(6)(7). One of the publications reported that two women diagnosed with Hashimoto's thyroiditis suffered from infertility, and in both, MTHFR gene polymorphisms were identified (7).…”

Section: Introductionmentioning

confidence: 99%

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Association of methylenetetrahydrofolate reductase ( MTHFR ) gene polymorphisms (C677T and A1298C) with thyroid dysfunction: A meta-analysis and trial sequential analysis

Rui¹,

Pu²,

Tan³

et al. 2022

Archives of Endocrinology and Metabolism

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“…It is known that folliculogenesis, ovulation, fertilization, and ovarian reserves are adversely affected by hypothyroidism. It has been reported that the menstrual cycle of Hashimoto patients is adversely affected by the disease, and the incidence of infertility is higher in women with thyroid-related problems (5,6).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Premature Ovarian Failure in Patients With Autoimmune Thyroiditis

et al. 2022

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Introduction and Aim: Premature ovarian failure is the loss of function of the ovaries under the age of forty that autoimmunity is a factor in some cases. Anti-Müllerian hormone is secreted by the granulosa cells of the ovarian follicles. Ovarian reserve can be accurately assessed with AMH measurements. This study aimed to evaluate the ovarian reserve by Anti-Müllerian hormone level in women who were diagnosed with autoimmune thyroiditis. Methods: This is a retrospective study, covers the 10-year period between January 2011 and May 2021. Women under the age of 35 who were followed up and treated for autoimmune thyroiditis constitute the sample of the study. Participants' ovarian reserves were analyzed using age specific AMH levels. Thyroid hormone levels were measured in the radioimmunoassay laboratory in the health center where the study was conducted. Results: Some participants did not have infertility (66.6%). 147 (38.7%) of the participants were euthyroid. 197 participants (51.8%) had a low ovarian reserve, 229 (60.3%) of the participants had high anti-TPO and 217 (57.2%) had high anti-TG levels. Participants with low ovarian reserve show a statistically significant difference between the groups in terms of thyroid hormone analysis results (p

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A hidden cause of infertility in hypothyroid patients

Abstract: Methylene tetrahydrofolate reductase (MTHFR) gene mutations could be the cause of infertility in hypothyroid patients. Hence, it is worthy to screen for MTHFR gene mutations in infertile hypothyroid females and their partners if infertility persists after optimizing thyroid function.

Cited by 5 publications

References 31 publications

MTHFR 1298A>C Substitution is a Strong Candidate for Analysis in Recurrent Pregnancy Loss: Evidence from 14,289 Subjects

MTHFR 1298A>C Substitution is a Strong Candidate for Analysis in Recurrent Pregnancy Loss: Evidence from 14,289 Subjects

Association of methylenetetrahydrofolate reductase ( MTHFR ) gene polymorphisms (C677T and A1298C) with thyroid dysfunction: A meta-analysis and trial sequential analysis

Prevalence of Premature Ovarian Failure in Patients With Autoimmune Thyroiditis

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