Relationship between toothpastes properties and patient-reported discomfort: crossover study

Bruno, Mariana; Taddeo, Fernando; Medeiros, Igor Studart; Boaro, Letícia Cristina Cidreira; Moreira, Maria Stella; Marques, Márcia Martins; Calheiros, Fernanda Calabró

doi:10.1007/s00784-015-1539-8

Cited by 15 publications

(12 citation statements)

References 49 publications

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“…Patients receiving ACP-CPP experienced reduced dental sensitivity both in office, immediately following bleaching, and at home. Discomfort during bleaching procedures is a major issue in the specific field [30], thus the combination of intervention procedures joining together rapid aesthetic effects with reduced pain for the patients are urgently needed. In this view, aimed at limiting the discomfort for the patients that must frequently attend in-office bleaching, we determined whether ACP-CPP administration during at-home procedures might limit dental sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Effects of Amorphous Calcium Phosphate Administration on Dental Sensitivity during In-Office and At-Home Interventions

Oldoini¹,

Bruno

Genovesi³

et al. 2018

Dentistry Journal

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Background. Tooth bleaching is the most frequently employed whitening procedure in clinics. The major side effect of tooth bleaching is dental sensitivity during and after the treatment. Here, we evaluated whether the administration of amorphous calcium phosphate (ACP), during in-office and at-home procedures may impact on dental sensitivity. Methods. Eighty patients, responding to the study requirements were enrolled according to the following criteria. Group 1 (n = 40), received in-office, 10% ACP prior to 30% professional hydrogen peroxide application. The whitening procedure continued at home using 10% carbamide peroxide with 15% ACP for 15 days. Group 2 (n = 40) received only 30% hydrogen peroxide application and continued the whitening procedures at home, using 10% carbamide hydroxide, without ACP- Casein phosphopeptides (CPP), for 15 days. Dental sensitivity was recorded with a visual analogue scale (VAS) at baseline, immediately after, and at 15 days after treatment in the two groups. Results. We observed that patients receiving ACP in the bleaching mixture experienced decreased dental sensitivity (* p ≤ 0.05), as detected by VAS scale analysis immediately following the procedures. Patients receiving ACP-CPP during at-home procedures showed a statistically significant (*** p ≤ 0.0001) reduction of dental sensitivity. Conclusions. We demonstrated that ACP-CPP administration, while exerting the same whitening effects as in control subjects receiving potassium fluoride (PF), had an impact on the reduction of dental sensitivity, improving patient compliance.

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Section: Discussionmentioning

confidence: 99%

Effects of Amorphous Calcium Phosphate Administration on Dental Sensitivity during In-Office and At-Home Interventions

Oldoini¹,

Bruno

Genovesi³

et al. 2018

Dentistry Journal

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“…The most commonly used are derivatives of silica (25), incorporated to ensure the removal of bacterial plaque and reduce the build-up of other superficial deposits on the tooth structure. The abrasiveness of a toothpaste can be influenced by the difference in hardness between the abrasive and the dentin, the composition and microstructure of the abrasive, its concentration, size and shape (26). The larger CT12 roughness values may be related to the hydrated silica that has increased hardness compared to calcium carbonate in the CSPR.…”

Section: Discussionmentioning

confidence: 99%

“…The characteristics of the abrasive particles, along with the chemical influences of other ingredients in the toothpastes, may explain these findings (25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%

Influence of the Extended Use of Desensitizing Toothpastes on Dentin Bonding, Microhardness and Roughness

et al. 2017

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The aim of this study was to evaluate the influence of an extended use of desensitizing toothpastes (DTs) on dentin bonding, microhardness and roughness. One hundred and twenty bovine incisor teeth were randomly divided into four groups: G1, distilled water (WATER); G2, Colgate Total 12 (CT12); G3, Colgate Sensitive Pro-Relief (CSPR); and G4, Sensodyne Repair & Protect (SRP). Dentin surfaces were etched with 17% EDTA and 2 years of simulated tooth brushing (20,000 cycles) was performed on their surfaces. Knoop microhardness, surface roughness and scanning electron microscopy (SEM) were performed before and after the simulated tooth brushing. For microshear bonding test, a 2-step self-etching adhesive system (Clearfil SE Bond) was used and 0.8 mm diameter composite resin (Filtek Z350 XT) cylinders were built. Microshear test was performed with an orthodontic wire and with a crosshead speed of 0.5 mm/min. The data were analyzed for: 1) bond strength (one-way ANOVA), 2) microhardness intra-group (Student's test) and inter-group (one-way ANOVA/Tukey's test) comparisons, 3) roughness intra-group (Student's test/Wilcoxon's test) and inter-group (Kruskal-Wallis/Student-NewmanKeuls test) comparisons. The extended use of both dentifrices (conventional and for sensitive teeth) did not affect the bond strength and produced a significant increase in microhardness and roughness of the dentin, except for the microhardness of the SRP group. The simulated tooth brushing technique with water produced an increase in roughness, without reducing significantly the dentin microhardness.

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“…SDS (also known as Sodium Lauryl Sulphate) is a model irritant [ 25 ], and its use in this study as positive control is further informed by the fact that it is the most common foaming agent in toothpaste and mouthwashes where it is usually used at a concentration between 0.5% and 2% [ 26 ]. Despite this well-known toxicity of SDS and its clinically proven adverse effect in potentiating episodes of recurrent aphthous stomatitis [ 27 ] and burning mouth syndrome [ 28 ], SDS has not yet been displaced as the predominant detergent in personal oral care products.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Toxicity Evaluation of Carrageenan on Cells and Tissues of the Oral Cavity

et al. 2022

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Carrageenan is a highly potent anti-human papillomavirus (HPV) agent with the potential for formulation as a mouthwash against oral HPV infection. However, its toxic effect on tissues of the oral cavity is currently unknown. This study aims to evaluate the safety of carrageenan on human cells and tissues of the oral cavity. Human salivary gland cells and reconstructed human oral epithelium (RHOE) were used for this in vitro study. The cells were subjected to 0.005–100 µg/mL of carrageenan for 4, 12, and 24 h in quadruplicate. RHOE were exposed to 100 µg/mL of carrageenan for 24 h in triplicate and stained with hematoxylin/eosin for histological analyses. All experiments had saline and 1% sodium dodecyl sulphate (SDS) as negative and positive controls, respectively. Carrageenan tissue toxicity was evaluated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay to quantify cell viability. Tissue toxicity was further evaluated histologically by an oral pathologist to assess morphological changes. Our data showed that carrageenan did not significantly decrease cell and tissue viability when compared to the positive control. The histological evaluation of the RHOE also showed no loss of viability of the carrageenan-treated sample compared to untreated tissue. In contrast, 1% SDS-treated RHOE showed extensive tissue destruction. Our experiments suggest that carrageenan is safe for use in the oral cavity.

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Relationship between toothpastes properties and patient-reported discomfort: crossover study

Abstract: Toothpaste's properties should be well known for indication to patient therefore minimizing discomfort reports.

Cited by 15 publications

References 49 publications

Effects of Amorphous Calcium Phosphate Administration on Dental Sensitivity during In-Office and At-Home Interventions

Effects of Amorphous Calcium Phosphate Administration on Dental Sensitivity during In-Office and At-Home Interventions

Influence of the Extended Use of Desensitizing Toothpastes on Dentin Bonding, Microhardness and Roughness

In Vitro Toxicity Evaluation of Carrageenan on Cells and Tissues of the Oral Cavity

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