Effects of Amorphous Calcium Phosphate Administration on Dental Sensitivity during In-Office and At-Home Interventions

Abstract

Background. Tooth bleaching is the most frequently employed whitening procedure in clinics. The major side effect of tooth bleaching is dental sensitivity during and after the treatment. Here, we evaluated whether the administration of amorphous calcium phosphate (ACP), during in-office and at-home procedures may impact on dental sensitivity. Methods. Eighty patients, responding to the study requirements were enrolled according to the following criteria. Group 1 (n = 40), received in-office, 10% ACP prior to 30% professional hydrogen peroxide application. The whitening procedure continued at home using 10% carbamide peroxide with 15% ACP for 15 days. Group 2 (n = 40) received only 30% hydrogen peroxide application and continued the whitening procedures at home, using 10% carbamide hydroxide, without ACP- Casein phosphopeptides (CPP), for 15 days. Dental sensitivity was recorded with a visual analogue scale (VAS) at baseline, immediately after, and at 15 days after treatment in the two groups. Results. We observed that patients receiving ACP in the bleaching mixture experienced decreased dental sensitivity (* p ≤ 0.05), as detected by VAS scale analysis immediately following the procedures. Patients receiving ACP-CPP during at-home procedures showed a statistically significant (*** p ≤ 0.0001) reduction of dental sensitivity. Conclusions. We demonstrated that ACP-CPP administration, while exerting the same whitening effects as in control subjects receiving potassium fluoride (PF), had an impact on the reduction of dental sensitivity, improving patient compliance.

Post-Operative Sensitivity and Color Change Due to In-Office Bleaching With the Prior Use of Different Desensitizing Agents: A Systematic Review

“…All selected studies were randomized clinical trials. Eleven studies [ 9 - 15 , 17 , 18 , 20 ] were performed using a parallel study design, whereas the other three [ 16 , 19 , 20 ] were performed as a split-mouth study. In addition, two studies [ 15 , 16 ] were single masked, three studies [ 18 , 20 , 21 ] were triple masked, whereas six studies [ 9 , 10 , 12 - 14 , 19 ] were double-masked.…”

“…The in-office bleaching procedure and concentration varied between the included studies. One study [ 11 ] used 28% of hydrogen peroxide (H2O2) concentration of bleaching agent, two studies [ 13 , 17 ] used 30% concentration, nine studies [ 9 , 10 , 12 , 14 , 16 , 18 , 20 , 21 ] used 35% and two studies [ 15 ] used 40% H2O2 concentration of bleaching agent.…”

“…The present systematic review included 13 RCT’s examining the effectiveness of various desensitizing agents and placebo with preceding application to the in-office bleaching procedure [ 9 - 21 ]. This resulted in a remarkably notable difference in the post-operative tooth sensitivity experienced immediately after the bleaching procedure [ 9 , 10 , 11 , 12 , 15 , 17 , 18 ]. The studies included in the current synthesis differed regarding the desensitizing agents used, the mode of application of the desensitizing agent, and the concentration of the bleaching gel used.…”

Dental Erosion Evaluation with Intact-Tooth Smartphone Application: Preliminary Clinical Results from September 2019 to March 2022

“…In orthodontic therapy, the risk of dental erosion is significantly increased. We are, therefore, recommended remineralizing toothpaste based on biomimetic nanohydroxyapatite (Biorepair Plus Total Protection or, in case of high sensitivity, Biorepair Plus Sensitive Teeth) or topical remineralizing products based on microrepair (Biorepair Desensitizing Repair-Enamel Shock Treatment) [ 12 , 15 ].…”

Dental Whitening Gels: Strengths and Weaknesses of an Increasingly Used Method

“…Another practical home-based intervention uses the so-called “whitestrips”, adhesive strips based on whitening agents that must be adhered to the teeth for 30 min, twice a day, for 14 days. Economical, practical and with a low risk of dentine hypersensitivity, this treatment has, however, a low efficacy, requires quite long times, and the results are guaranteed only for a few months [28].…”