Relationship between tissue glycation measured by autofluorescence and pulse wave velocity in young and elderly non-diabetic populations

Watfa, Ghassan; Soulis, Georges; Tartagni, E.; Kearney‐Schwartz, Anna; Borghi, Claudio; Salvi, Paolo; Bénétos, Athanase

doi:10.1016/j.diabet.2012.04.004

Cited by 20 publications

(20 citation statements)

References 30 publications

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“…Our results are in agreement with previous studies, which demonstrated that skin AGEs are associated with arterial stiffening in type 1 diabetes mellitus, 16 heart disease, and 10 end-stage renal disease 11 and in the elderly. 12,19 We found relatively small standardized regression coefficients in these associations. In comparison, sβs and 95% CIs of the associations between mean arterial pressure and age on the one hand and cfPWV on the other were 0.37 (0.31-0.43) and 0.31 (0.24-0.38), respectively, in our study.…”

Section: Discussionmentioning

confidence: 90%

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Skin Autofluorescence and Pentosidine Are Associated With Aortic Stiffening

et al. 2016

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Abstract-Arterial stiffening, as characterized by an increase in carotid-femoral pulse-wave velocity or pulse pressure, increases the risk of cardiovascular disease, especially among individuals with type 2 diabetes mellitus. Advanced glycation end products are hypothesized to play a role in the development of arterial stiffness. Therefore, we investigated the association between skin autofluorescence, an estimate of tissue advanced glycation end products, and plasma advanced glycation end products on the one hand and arterial stiffening on the other in 862 participants of The Maastricht Study (mean age of 60 years; 45% women) with normal glucose metabolism (n=469), impaired glucose metabolism (n=140), or type 2 diabetes (n=253). Associations were analyzed with linear regression analysis and adjusted for potential confounders. We found that higher skin autofluorescence as measured by the AGE Reader and plasma pentosidine were independently associated with higher carotid-femoral pulse-wave velocity (sβ 0.10; 95% confidence interval, 0.03-0.17 and 0.10; 0.04-0.16, respectively) and central pulse pressure (sβ 0.08; 95% confidence interval 0.01-0.15 and 0.07; 0.01-0.13, respectively). The associations between skin autofluorescence and pentosidine, and carotid-femoral pulsewave velocity were more pronounced in individuals with type 2 diabetes mellitus (P-interaction<0.10). These results support the hypothesis that accumulation of advanced glycation end products is involved in arterial stiffening and may explain part of the increased risk of cardiovascular disease in individuals with type 2 diabetes mellitus. carotid to femoral pulse-wave velocity (cfPWV) or pulse pressure, both measures of aortic stiffening, in a population-based setting, including individuals with normal glucose metabolism (NGM), impaired glucose metabolism (IGM), and T2DM. In view of these considerations, the aims of our study were, first, to evaluate the independent association between SAF and plasma AGEs on the one hand and measures of arterial stiffening, ie, cfPWV, central pulse pressure, and 24-hour ambulatory pulse pressure, on the other. Second, to examine whether these associations differed between individuals with NGM, IGM, or T2DM. Methods Study Population and DesignIn this study, we used data from The Maastricht Study, an observational prospective population-based cohort study. The rationale and methodology have been described previously. 22 In brief, the study focuses on the cause, pathophysiology, complications, and comorbidities of type 2 diabetes mellitus (T2DM) and is characterized by an extensive phenotyping approach. Eligible for participation were all individuals aged between 40 and 75 years and living in the southern part of the Netherlands. Participants were recruited through mass media campaigns and from the municipal registries and the regional Diabetes Patient Registry via mailings. Recruitment was stratified according to known T2DM status for reasons of efficiency. The present report includes cross-sectional data from the ...

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Section: Discussionmentioning

confidence: 90%

“…[10][11][12][13][14][15][16][17][18][19][20] Only one case-control study investigated this association in individuals with T2DM. This study found no association between serum pentosidine and heart-brachial pulse-wave velocity or brachialankle pulse-wave velocity after adjustment for renal function.…”

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confidence: 99%

Skin Autofluorescence and Pentosidine Are Associated With Aortic Stiffening

et al. 2016

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“…Others have reported an independent association between skin AF and aortic PWV in patients with type 1 diabetes and with brachial-ankle PWV in 120 Japanese patients with end-stage renal failure, 27,44 but this is not universally seen. 45 Of note, was the lack of difference in the traditional CV risk scores between patient and controls. Current calculators consider smoking categorically as 'current smoker or not' but have no lung disease-related factor or gradation of smoking exposure.…”

Section: Discussionmentioning

confidence: 99%

Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease

et al. 2016

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With the increased cardiovascular (CV) morbidity and mortality in subjects with chronic obstructive pulmonary disease (COPD), there is a priority to identify those patients at increased risk of cardiovascular disease. Stable patients with COPD (n = 185) and controls with a smoking history (n = 106) underwent aortic pulse wave velocity (PWV), blood pressure (BP) and skin autofluorescence (AF) at clinical stability. Blood was sent for fasting lipids, soluble receptor for advanced glycation end products (sRAGE) and CV risk prediction scores were calculated. More patients (18%) had a self-reported history of CV disease than controls (8%), p = 0.02, whilst diabetes was similar (14% and 10%), p = 0.44. Mean (SD) skin AF was greater in patients: 3.1 (0.5) AU than controls 2.8 (0.6) AU, p < 0.001. Aortic PWV was greater in patients: 10.2 (2.3) m/s than controls: 9.6 (2.0) m/s, p = 0.02 despite similar BP. The CV risk prediction scores did not differentiate between patients and controls nor were the individual components of the scores different. The sRAGE levels were not statistically different. We present different indicators of CV risk alongside each other in well-defined subjects with and without COPD. Two non-invasive biomarkers associated with future CV burden: skin AF and aortic PWV are both significantly greater in patients with COPD compared to the controls. The traditional CV prediction scores used in the general population were not statistically different. We provide new data to suggest that alternative approaches for optimal CV risk detection should be employed in COPD management.

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“…In our current study, a significant association for plasma AGE concentration was observed in patients with diabetes or prediabetes but not in subjects with normoglycemia. Most of the studies with skin autofluorescence showed a significant association with arterial stiffness [35,36,37]. However, the possibility of publication bias with this relatively new technique cannot be entirely excluded.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study on Skin and Plasma Advanced Glycation End Products and Their Associations with Arterial Stiffness

Liu

Huang

Cheng

et al. 2016

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Background: We compared skin and plasma measurements of advanced glycation end products (AGEs), with particular focus on their levels in the presence of hypertension or diabetes and prediabetes and their associations with arterial stiffness in outpatients with suspected or diagnosed hypertension. Methods: Skin AGE accumulation was measured as autofluorescence on the left forearm using the skin autofluorescence Reader and expressed in arbitrary units in the range from 0 to 25. Plasma AGE concentration was measured by the enzyme-linked immunosorbent assay method and logarithmically transformed for statistical analysis. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV) using the SphygmoCor system (Sydney, Australia). Results: The 218 participants (96 [44.0%] men, mean age 51.9 years) had a mean skin autofluorescence of 1.89 arbitrary units, plasma AGE concentration of 4.47 μg/ml, and cfPWV of 8.0 m/s. Skin autofluorescence was significantly correlated with plasma AGEs in diabetic or prediabetic patients (n = 31, r = 0.37, p = 0.04) but not in subjects with normoglycemia (n = 187, r = -0.05, p = 0.48). Nonetheless, both measurements were significantly (p ≤ 0.001) higher in men (2.00 arbitrary units and 6.73 μg/ml, respectively) than women (1.81 arbitrary units and 3.60 μg/ml, respectively) and in diabetic or prediabetic (2.03 arbitrary units and 6.61 μg/ml, respectively) than normoglycemia subjects (1.87 arbitrary units and 4.17 μg/ml, respectively), but similar in hypertensive (n = 105) and normotensive subjects (n = 113, p ≥ 0.35). In adjusted multiple regression analyses, plasma AGE concentration, but not skin autofluorescence (p ≥ 0.37), was significantly associated with cfPWV in all subjects (β 0.44 m/s for each 10-fold increase; p = 0.04) and in subgroups of men and diabetes and prediabetes (β 0.12-0.55 m/s for each 10-fold increase; p ≤ 0.02). Conclusions: Although skin and plasma AGEs were similarly associated with gender and diabetes or prediabetes, they might measure something different and have different clinical relevance, such as for arterial stiffness.

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Relationship between tissue glycation measured by autofluorescence and pulse wave velocity in young and elderly non-diabetic populations

Cited by 20 publications

References 30 publications

Skin Autofluorescence and Pentosidine Are Associated With Aortic Stiffening

Skin Autofluorescence and Pentosidine Are Associated With Aortic Stiffening

Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease

A Comparative Study on Skin and Plasma Advanced Glycation End Products and Their Associations with Arterial Stiffness

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