Relationship Between the Presence of Helicobacter Pylori With Inflammatory Endoscopic Changes in Gastroduodenal Mucosa

Abstract

Background: The influence of Helicobacter pylori (HP) in inflammatory disorders of the digestive mucosa has been the subject of several studies since socioeconomic, personal and environmental factors were implicated in the bacteria transmission. Aim: To correlate the inflammatory endoscopic findings with HP infection and the onset of mucosal diseases mucous of the upper digestive tract. Method: Comparative observational study, in which were collected data from 2247 patients who underwent upper endoscopy and biopsies for HP with urease test. The patients were divided into two groups: HP+ and HP- (control) in which endoscopic findings were observed for the following changes: esophagitis, esophageal ulcer, gastritis, erosive gastritis, gastric ulcer, bulboduodenitis, bulbar ulcer and without disease. Results: As for esophagitis, there was little disparity in the distribution favorable to HP+ group (HP+ =67.11% and HP- =69.89%) and esophageal ulcer (HP+ =0% and HP- =0, 21%). Gastritis was favorable to HP- group (HP+ =78.34% and HP- =73.63%), as well as erosive gastritis (HP+ = 67,11% and HP- = 64,55%), in bulboduodenitis (HP+ =1,87% and HP- 1,23%), in gastric ulcer (HP+ =2,14% and HP- =2,03%) and in the absence of alterations in the HP+ group (4.81%) with the HP- control group (6,30%), in which there was little disproportion in favor of HP- group, but without statistical significance. As for the bulbar ulcer (HP +=10.16% and HP- =4.48%), there was statistically significant (p=0.00001). Conclusion: There is no difference between HP+ and HP- groups in inflammatory changes in endoscopic gastroduodenal mucosa, except for the relationship between HP and bulbar ulcer.

Linked color imaging confers benefits in profiling H. pylori infection in the stomach

“…A single-center study reported that H. pylori -associated gastritis was connected with endoscopic modifications and histopathology in a prospective cohort of children 19 . It was also shown that the conventional endoscopy features can be used to diagnose H. pylori 20 21 22 , but the efficiency of WLE was relatively poor 23 24 . Endocytoscopy may facilitate in vivo gastric mucosal histopathology 25 , but it is time-consuming and some patients cannot tolerate it.…”

Gastrite Crônica Relacionada Com a Bactéria Helicobacterpylori

“…Pequena proporção de células bacterianas adere ao epitélio da mucosa. Sua forma espiralada e flagelos a tornam móvel no ambiente mucoso e sua eficaz urease a protege contra o ácido, catalisando a hidrólise de ureia para produzir tampão de amônia (RIBEIRO et al, 2016).…”

Prevalência De Helicobacter Pylori Em Pacientes Diagnosticados Com Úlcera Péptica

“…Sobre a infecção pela Helicobacter pylori, sabe-se que a colonização da mucosa do trato gastrointestinal (TGI) por essa bactéria gera predisposição à úlcera péptica (RIBEIRO et al, 2016), pois ela atua reduzindo a proteção da mucosa gastrointestinal ao reduzir a secreção de bicarbonato pelas células desse sistema, desencadeando a lesão induzida por ácido (CHMIELA and KUPCINSKAS, 2019).…”