Relationship between the Phase Angle and Volume of Tumours in Patients with Lung Cancer

Abstract

Background/Aims: The phase angle (PA) obtained by bioelectrical impedance has been used as a predictor of nutritional status in cancer. This study aimed to verify the association between the PA and tumour volume in non-small cell lung cancer (NSCLC) patients. Methods: Volumetric determination of the tumour mass was performed using a computerised image analysis system incorporated in helical tomography. Lesion segmentation was performed by a semi-automatic process using a region growth algorithm with voxel aggregation. The PA was measured by bioelectrical impedance. Results: A total of 30 male patients with a mean age of 65.6 years were evaluated. The mean values observed for body mass index, PA and tumour volume were 22.5 ± 4.19, 5.66 ± 0.9° and 163.2 ± 207.5 ml, respectively. The tumour volumes were negatively correlated with the PA (r = –0.55; p < 0.001) and positively correlated with the ratio between the extracellular mass and the body cell mass (ECM/BCM) (r = 0.59; p < 0.001). In multivariate analysis, independent predictors for both PA and ECM/BCM were tumour volume and Karnofsky performance status score. Conclusions: In NSCLC, the PA is closely associated with tumour volume, which may be important in early nutritional intervention.

Association of Bioelectrical Impedance Analysis–Derived Phase Angle and Sarcopenia in Older Adults

“…Low phase angle was reported to be a good predictor of worse cancer survival 6 , 20 – 24 . Castanho et al reported that phase angle was inversely correlated with tumor volume in patients with lung cancer (mean age: 65.6 years) 25 . Phase angle was reported to be positively associated with survival among patients receiving hemodialysis 7 .…”

Perfil Nutricional de Pacientes com Câncer de Cavidade Oral em Pré-Tratamento Antineoplásico

“…numerosos fatores, além dos nutricionais, que podem modificar a concentração das proteínas séricas, devem ser considerados, tais como: variações do estado de hidratação, aumento do catabolismo, infecção ou inflamação, não se devendo utilizar o método isoladamente para diagnóstico nutricional 18 . o ângulo de fase está associado à qualidade, ao tamanho e à integridade celular, e tem sido utilizado como preditor do estado nutricional no câncer 19 ; porém ainda não possui um ponto de corte definido para diagnóstico nutricional de pacientes com câncer de cavidade oral, o que impossibilitou a comparação dos achados deste estudo com outros realizados anteriormente com essa população. além disso, não foi observada, nesta pesquisa, associação estatisticamente significativa entre ângulo de fase e estadiamento da doença, medidas antropométricas, albumina, pré-albumina e Pcr.…”

A Bioimpedance Analysis of Head-and-neck Cancer Patients Undergoing Radiotherapy

“…The bioelectrical Φ has consistently been shown in several studies to have great prognostic relevance with respect to morbidity and mortality in various disease processes, including hiv, sepsis, breast cancer, lung cancer, and colon cancer [10][11][12][13][14][15][16] . In addition, Φ has been found to be an indicator for cell membrane integrity, distribution of water between the intracellular and extracellular spaces, and prediction of body cell mass in various other disease conditions [17][18][19] .…”